抗人血小板单克隆抗体的研究——Ⅱ.抗血小板糖蛋白Ⅰ单克隆抗体——SZ-2

单克隆抗体SZ-2特异作用于人血小板和巨核细胞,测定10例正常人血小板SZ-2结合位点数为15200±4100/血小板,KD值0.66±0.33nM。SZ-2所识别的抗原对糜蛋白酶敏感,但对神经氨酸酶不敏感,亲和层析技术证明其为血小板糖蛋白Ib(GPIb)。SZ-2与其它抗GPIb单克隆抗体不同,它不仅抑制瑞斯托霉素诱导的血小板聚集,而且也抑制Ⅰ型胶原和血小板活化因子诱导的血小板聚集,并抑制上述诱导剂引起的血小板5-HT和βTG释放。     

STUDIES ON MONOCLONAL ANTIBODIES AGAINST HUMAN PLATELETS——A MONOCLONAL ANTIBODY TO HUMAN PLATELET GLYCOPROTEIN I——SZ-2

A monocloual antibody, SZ-2, reacts specifically on human platelets and megakaryocytes. The plate-lets from 10 normal donors are bound to 15,200±4,100 SZ-2 molecules/platelet. The antigen recognizedby SZ-2 is chymotrypsin-sensitive but neuraminidase-insensitive, and has been identified as glycoproteinIb (GPIb) by an affinity chromatography technique. SZ-2 is different from other monoclonal antibodiesto GPIb. It inhibits not only platelet aggregation induced by ristocetin, but also platelet aggregation in-duced by collagen (type Ⅰ) and by PAF. SZ-2 also inhibits platelet serotonin and β-thromboglobulinrelease in response to these stimuli.     

高阶中立型非线性偏微分方程解的振动性

考虑一类具有连续分布滞量的高阶中立型偏微分方程的振动性 ,给出这类方程在两类边值条件下解的振动的准则 .