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1.
Biomolecules such as serum proteins can interact with drugs in the body and influence their pharmaceutical effects. Specific and precise methods that analyze these interactions are critical for drug development or monitoring and for diagnostic purposes. Affinity capillary electrophoresis (ACE) is one technique that can be used to examine the binding between drugs and serum proteins, or other agents found in serum or blood. This article will review the basic principles of ACE, along with related affinity-based capillary electrophoresis (CE) methods, and examine recent developments that have occurred in this field as related to the characterization of drug–protein interactions. An overview will be given of the various formats that can be used in ACE and CE for such work, including the relative advantages or weaknesses of each approach. Various applications of ACE and affinity-based CE methods for the analysis of drug interactions with serum proteins and other binding agents will also be presented. Applications of ACE and related techniques that will be discussed include drug interaction studies with serum agents, chiral drug separations employing serum proteins, and the use of CE in hybrid methods to characterize drug binding with serum proteins.  相似文献   
2.
《印度化学会志》2022,99(11):100767
The optimized geometric parameters of the 2-Amino-6-chlorofluoren-9-one (2A6CF9O) compound were estimated by employing density functional theory. The electronic characteristics of the molecule were explored using molecular frontier orbital energies and the MEP surface. Kamlet's and Catalan's multiple linear regression techniques along with different polarity functions were used to investigate the influence of pure solvents on spectral properties. In the system, both general solute-solvent and hydrogen bonding interactions are active. However, as compared to normal solute-solvent interactions, hydrogen bonding interactions have a smaller role. In addition, using computed ground state dipole moment, solvatochromic correlations were employed to infer excited state dipole moment.  相似文献   
3.
Yue Qiao 《中国物理 B》2022,31(6):64214-064214
High-order harmonic generation (HHG) from an atom illuminated by a sinusoidally phase-modulated pulse is investigated by solving the time-dependent Schrödinger equation. The spectral shift that occurs in atomic HHG can be achieved easily using our laser pulse. It is shown that the photon energy of the generated harmonics is controllable within the range of 1 eV. The shift of the frequency peak position is rooted in the asymmetry of the rising and falling parts of the laser pulse. We also show that by varying the phase parameters in the frequency domain of the laser one can adjust and control the shift in atomic harmonic spectra.  相似文献   
4.
Yu-Bo Li 《中国物理 B》2022,31(6):64207-064207
We investigated Goos-Hänchen (GH) and Imbert-Fedorov (IF) shifts of a reflective beam on a twisted bilayer of hexagonal boron nitride (hBN), where a left circularly polarized beam was incident on the surface. Our results demonstrate that the twist angle between the two optical axes plays an important role in obtaining large shifts with a high reflectivity. The GH shift with 10λ0 is achieved, while the reflectivity is near 100% by tuning the twist angle. The maximum of the IF shift is found in the certain condition satisfied by the reflective coefficients, and the shift strongly depends on the twist angle between the optical axes of the two slabs. The spatial shifts obtained directly from the GH and IF shift definitions were provided, which indicate that the theoretical results from the stationary phase method are believable. These results may open up a new way for developing the nano-optical devices.  相似文献   
5.
Shuo-Qing Liu 《中国物理 B》2022,31(7):74101-074101
We establish the beam models of Goos-Hänchen (GH) and Imbert-Fedorov (IF) effects in tilted Weyl semimetals (WSMs), and systematically study the influences of Weyl cone tilting and chemical potential on the GH and IF shifts at a certain photon energy 1.96 eV. It is found that the GH and IF shifts in tilted type-I and type-Ⅱ WSMs are both almost symmetric about the Weyl cone tilting. Meanwhile, the GH and IF shifts in type-I WSMs almost do not change with the tilt degree of Weyl cones, while those in type-Ⅱ WSMs are extremely dependent on tilt degree. These trends are mainly due to the nearly symmetric distribution of WSMs conductivities, where the conductivities keep stable in type-I WSMs and gradually decrease with tilt degree in type-Ⅱ WSMs. By adjusting the chemical potential, the boundary between type-I and type-Ⅱ WSMs widens, and the dependence of the beam shifts on the tilt degree can be manipulated. Furthermore, by extending the relevant discussions to a wider frequency band, the peak fluctuation of GH shifts and the decrease of IF shifts occur gradually as the frequency increases, and the performance of beam shifts at photon energy 1.96 eV is equally suitable for other photon frequencies. The above findings provide a new reference for revisiting the beam shifts in tilted WSMs and determining the types of WSMs.  相似文献   
6.
This paper introduces an open conjecture in time-frequency analysis on the linear independence of a finite set of time-frequency shifts of a given L2 function. Firstly, background and motivation for the conjecture are provided. Secondly, the main progress of this linear independence in the past twenty five years is reviewed. Finally, the partial results of the high dimensional case and other cases for the conjecture are briefly presented.  相似文献   
7.
许家喜  麻远 《化学教育》2022,43(24):115-119
亲核性1,2-重排反应是有机化学的重要反应之一,重排中离去基团的离去和迁移基团的迁移步骤既可以是分步的,也可以是协同的,但是迁移基团的构型始终保持不变。本文用超共轭效应和反应过程中有机立体电子效应解释了此现象,掌握一般规律,希望能够从教学上便于教师讲授和学生学习理解。  相似文献   
8.
国内呼叫企业在保证每个坐席人员周内当值相同班次情况下,通过灵活安排周内当班日期与班次来制定排班方案。针对该实际排班场景,构建问题整数规划模型。通过对问题数据特征及优化性质分析,以及对班次人力有效满足区段电话服务需求的量化指标表征,分别提出两个构造性启发式算法。使用企业实例数据对模型算法进行计算实验。实验结果显示,整数规划模型适合于求解小规模排班问题最优解,而启发式算法能够以小计算成本获得大规模排班问题优化解。最后讨论保证员工上班规律性的同班次用工制度对企业人力成本控制的影响。  相似文献   
9.
We propose to reduce the (spectral) condition number of a given linear system by adding a suitable diagonal matrix to the system matrix, in particular by shifting its spectrum. Iterative procedures are then adopted to recover the solution of the original system. The case of real symmetric positive definite matrices is considered in particular, and several numerical examples are given. This approach has some close relations with Riley's method and with Tikhonov regularization. Moreover, we identify approximately the aforementioned procedure with a true action of preconditioning.  相似文献   
10.
Nonlinear feedback shift registers (NFSRs) are widely used in stream cipher design as building blocks. The cascade connection of NFSRs, known as an important architecture, has been adopted in Grain family of stream ciphers. In this paper, a new sufficient condition under which an NFSR cannot be decomposed into the cascade connection of two smaller NFSRs is presented, which is easy to be verified from the algebraic normal form (ANF) of the characteristic function. In fact, our results are also applicable to nonsingular Boolean functions, which actually improve a previous research of Rhodes [6] where the characteristic functions of NFSRs cannot be contained.  相似文献   
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