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1.
建立了碰撞池-电感耦合等离子体质谱法测定芝麻中痕量的锗元素(germanium , Ge)。采用微波消解,碰撞池(KED模式)-电感耦合等离子体质谱检测,在线引入内标元素铑(Rh),同时消解液中加入3%正戊醇增敏。结果 3 % 正戊醇可使74Ge的上机检测信号强度提高2.85倍,74Ge校正曲线线性相关系数为1.00000,检出限为0.0555 μg/kg,加标回收率为92.0%~106%,相对标准偏差(relative standard deviation, RSD%)为2.6%~4.3%。采用建立的方法测定7种国家标准物质,检测结果均在认定值范围内,RSD%为2.5%~8.8%。结论 该方法灵敏度高、准确,可实现批量检测,适用于芝麻中痕量锗的检测。 相似文献
2.
Pavitra Laohapaisan Kanyapat Lumyong Jumreang Tummatorn Charnsak Thongsornkleeb Jaruwan Chatwichien Nantamon Supantanapong Somsak Ruchirawat 《化学:亚洲杂志》2022,17(1):e202101212
ortho-Alkynylarylketone derivatives were employed as key precursors for a one-pot synthesis of arylnaphthalenelactone and furanonaphthol libraries. In this work, we discovered a cost-effective protocol to prepare arylnaphthalenelactones in one-pot using inexpensive starting material, malonate ester, which was conveniently functionalized leading to a variety of structures. Moreover, we also found an unexpected oxy-dearylation reaction which could be used to synthesize furanonaphthol analogs. These novel methods could be applied to a broad range of substrates to give the corresponding products in up to 83% yield. Notably, these classes of compounds exhibited more significant inhibition against protein-tyrosine phosphatase 1B (PTP1B) enzyme than a standard compound, ursolic acid. 相似文献
3.
Carotenoids are an essential component of cashew and can be used in pharmaceuticals, cosmetics, natural pigment, food additives, among other applications. The present work focuses on optimizing and comparing conventional and ultrasound-assisted extraction methods. Every optimization step took place with a 1:1 (w:w) mixture of yellow and red cashew apples lyophilized and ground in a cryogenic mill. A Simplex-centroid design was applied for both methods, and the solvents acetone, methanol, ethanol, and petroleum ether were evaluated. After choosing the extractor solvent, a central composite design was applied to optimize the sample mass (59–201 mg) and extraction time (6–34 min). The optimum conditions for the extractor solvent were 38% acetone, 30% ethanol, and 32% petroleum ether for CE and a mixture of 44% acetone and 56% methanol for UAE. The best experimental conditions for UAE were a sonication time of 19 min and a sample mass of 153 mg, while the CE was 23 min and 136 mg. Comparing red and yellow cashews, red cashews showed a higher carotenoid content in both methodologies. The UAE methodology was ca. 21% faster, presented a more straightforward composition of extracting solution, showed an average yield of superior carotenoid content in all samples compared to CE. Therefore, UAE has demonstrated a simple, efficient, fast, low-cost adjustment methodology and a reliable alternative for other applications involving these bioactive compounds in the studied or similar matrix. 相似文献
4.
Yan Fang Yangzom Dawa Qilan Wang Yue Lv Wei Yu Gang Li Jun Dang 《Journal of separation science》2022,45(14):2435-2445
Saxifraga atrata is an important traditional Tibetan medicine used to treat cough and pneumonia, and has tremendous medicinal potential. In this study, we devised a technique to separate 1,1-diphenyl-2-picrylhydrazyl inhibitors from a methanol extract of S. atrata. The material was first processed using MCI GEL CHP20P medium-pressure liquid chromatography, yielding 1.1 g of the target fraction Fr2. Subsequently, online hydrophilic interaction liquid chromatography-1,1-diphenyl-2-picrylhydrazyl assay was used to identify prospective 1,1-diphenyl-2-picrylhydrazyl inhibitors, and two 1,1-diphenyl-2-picrylhydrazyl inhibitor fractions (Fr24 and Fr25) were identified from Fr2. Then, medium-pressure preparation was continued using an XIon column to separate two 1,1-diphenyl-2-picrylhydrazyl inhibitor fractions (Fr24 and Fr25). The target compound was concentrated in fractions Fr24 and Fr25 using reverse-phase liquid chromatography during further separation procedures. Finally, the purity, structure, and 1,1-diphenyl-2-picrylhydrazyl inhibitory activity of the isolated 1,1-diphenyl-2-picrylhydrazyl inhibitors were determined. Two 1,1-diphenyl-2-picrylhydrazyl inhibitors (adenosine with the half maximal inhibitory concentration of 66.87 ± 14.33 μM and (-)-4-O-(E)-caffeoyl-l -threonic acid with the half maximal inhibitory concentration of 59.06 ± 5.02 μM) were isolated with purities exceeding 95%. The results showed that this technology is effective in the targeted separation of antioxidants from natural products. 相似文献
5.
Dibenzyl trisulfide (DTS) is a natural compound with potential cancer-preventive properties occurring in Petiveria alliacea L., an ethnomedicinal plant native to the Americas. Previous studies revealed its inhibitory activity toward cytochrome P450 (CYP)1 enzymes, key in the activation of environmental pollutants. Accordingly, the aim of this study was to design novel DTS analogues, aimed at improving not only inhibitory activity, but also specificity toward CYP1A1. This was achieved by targeting interactions with CYP1A1 residues of identified importance. Three-dimensional structures for the novel analogues were subjected to molecular docking with several CYP isoforms, before being ranked in terms of binding affinity to CYP1A1. With three hydrogen bond donors, two hydrogen bond acceptors, a molecular mass of 361 Da, and a log P of 3.72, the most promising DTS analogue obeys Lipinski's rule of five. Following synthesis and in vitro validation of its CYP1A1-inhibitory properties, this compound may be useful in future cancer-preventive approaches. 相似文献
6.
The context of molecular structronics (from “molecular structure” and “electronics”) is that of molecular-level electrochemical storage of energy of sustainable origin (wind, solar). Due to its discontinuous availability, storage of this energy is a key issue. The targeted type of storage relies on implementing “electron reservoirs” within the structronic molecules by electrochemically forming dedicated chemical bonds according to non-catalytic processes. Reservoir bonds are therefore integral parts of the molecular backbone of structronic assemblies. When filled, electron reservoirs manifest themselves in the form of elongated covalent bonds that are to be cleaved for electron releasing (discharging) on demand. The scope of this short review is limited to pyridinium electrophores as particularly suited building blocks for the development of structronics. 相似文献
7.
延安是中国共产党领导革命的中心和战略总后方,是革命的红色摇篮。延安时期出版了大量具有历史、文化以及教育意义的红色文献,这些红色文献记载了中国共产党波澜壮阔的发展历程,也反映了延安时期不断发展的科技生产水平与独特的制浆造纸工艺,具有重要的研究价值。然而,延安时期出版的红色文献虽距今不到百年时间,但其保存现状不容乐观,普遍存在纸张老化、焦脆易碎等问题,大量文献急需科学检测与修复保护,以延长其保存寿命。目前,针对延安时期红色文献的检测研究仍存在较大空白。考虑到红色文献的珍贵性与特殊性,应当尽可能选择无损检测方法对其分析检测。基于衰减全反射-傅里叶变换红外光谱法(ATR-FTIR),以木素1 510 cm-1处特征峰与纤维素1 030 cm-1处特征峰的强度作为定量依据,建立了造纸原料与红色文献纸张中木素相对含量的无损检测方法。通过检测不同碱强度与碱浓度处理后的构皮、苦竹与杨木的木素含量,考察了制浆过程中碱处理条件对造纸原料脱木素程度的影响,同时体现了红外光谱法测定木素相对含量的普适性。以复旦大学图书馆藏的76册延安时期红色文献为研究对象,分析了红色文献的纸张木素含量与纸张pH值以及纸张氧化度的相互关系。结果表明,木素相对含量高于25%的红色文献,其纸张pH集中在3~4之间且纸张氧化度较高,文献整体保存状况堪忧;而木素相对含量低于25%的红色文献,其纸张氧化度与酸度较低,文献整体保存情况较好。以上结果验证了红外光谱无损检测法用于延安时期红色文献木素含量分析的可行性,并结合纸张氧化度与酸度数据提出了纸张木素含量的合适范围,为制浆造纸中植物原料的脱木素过程提供参考。拓展了红外光谱法在红色文献无损检测中的应用范围,以期为延安时期红色文献的修复与保护研究提供科学依据。 相似文献
8.
以食品发热包为主题情境,通过探析发热包成分、解密发热原理、计算原料配比、配制发热包等环节梳理酸和碱的性质、用途。从元素观、转化观的视角认识物质转化规律,体现物质研究的一般思路,凸显科学探究的基本过程。通过设计方案测定发热包中碳酸钠的含量,总结混合物成分鉴定及定量测定的方法;归纳气体定量测定的影响因素。呈现一堂学科观念、学科方法教学具体课例,凸显物质研究、定性检验、定量测定的基本方法。 相似文献
9.
《Arabian Journal of Chemistry》2022,15(9):104018
BackgroundNasopharyngeal cancer is a tumor that occurs in the mucous epithelium of the nasopharynx. Due to its rapid growth and early metastatic nature, the successful treatment of nasopharyngeal cancer is highly challenging.ObjectiveHere, we intended to assess the in vitro anticancer property of brassinin against the nasopharyngeal cancer C666-1 cells.MethodologyThe in vitro free radical scavenging property of the brassinin was assessed by various free radical scavenging activities such as FRAP, DPPH, chemiluminescence (CL), and ORAC assays. The cytotoxic level of the brassinin (1–50 µM) against the nasopharyngeal cancer C666-1 cells and normal Vero cells were assessed by the MTT cytotoxicity assay. The levels of TBARS, GSH, and the SOD activity was assessed using kits. The level of ROS generation, MMP, and apoptosis were investigated by the respective fluorescent staining techniques. The flow cytometry analysis was done to scrutinize the cell cycle arrest. The Bax/Bcl-2 level and caspase activities were examined using respective kits.ResultsThe brassinin treatment effectively scavenged the free radicals, which are assessed by the FRAP, DPPH, chemiluminescence (CL), and ORAC assays. The proliferation of brassinin treated C666-1 cells were decreased remarkably, while the same concentration of brassinin did not disturbed the Vero cell viability. The 30 µM of brassinin effectively increased the ROS production, depleted the MMP, and stimulated the apoptosis in the C666-1 cells. The brassinin increased the TBARS and depleted the GSH and SOD in the C666-1 cells. The flow cytometry analysis revealed that the brassinin administration improved the G0/G1 ratio and decreased the proportion of cells with ‘S’ and ‘G2/M’ phase. The Bax, caspase-3 and ?9 were elevated and Bcl-2 level was decreased in the brassinin administered C666-1 cells.ConclusionOur findings discovered that the brassinin has the capacity to prevent the proliferation and stimulate the apoptotic cell death C666‐1 cells via blocking cell cycle and increasing oxidative stress and apoptotic markers. Hence, it can be a talented therapeutic agent to treat the nasopharyngeal cancer in the future. 相似文献
10.
任梦阳 《中国无机分析化学》2022,12(2):52-55
建立了氟化氢铵消解地球化学样品,电感耦合等离子体质谱(ICP-MS)法测定样品中钨、锡和钼的方法。方法经过国家土壤和水系沉积物标准参考物质验证,方法的检出限钨为0.048μg/g、锡为0.079μg/g、钼为0.063μg/g,准确度(相对误差)钨为0.64%~6.28%、锡为0.29%~3.74%、钼为2.12%~7.41%,精密度(相对标准偏差)钨为0.13%~0.72%、锡为0.05%~1.2%、钼为0.03%~1.1%,能够满足《地质矿产实验室测试质量管理规范》的质量要求。方法具有操作简便、测试成本低、分析效率高、环境污染小等特点,适合于批量样品的分析测试。 相似文献