THPep: A machine learning-based approach for predicting tumor homing peptides

In the present era, a major drawback of current anti-cancer drugs is the lack of satisfactory specificity towards tumor cells. Despite the presence of several therapies against cancer, tumor homing peptides are gaining importance as therapeutic agents. In this regard, the huge number of therapeutic peptides generated in recent years, demands the need to develop an effective and interpretable computational model for rapidly, effectively and automatically predicting tumor homing peptides. Therefore, a sequence-based approach referred herein as THPep has been developed to predict and analyze tumor homing peptides by using an interpretable random forest classifier in concomitant with amino acid composition, dipeptide composition and pseudo amino acid composition. An overall accuracy and Matthews correlation coefficient of 90.13% and 0.76, respectively, were achieved from the independent test set on an objective benchmark dataset. Upon comparison, it was found that THPep was superior to the existing method and holds high potential as a useful tool for predicting tumor homing peptides. For the convenience of experimental scientists, a web server for this proposed method is provided publicly at http://codes.bio/thpep/.     

水下武器发射时流噪声研究

水下鱼雷武器发射噪声是潜艇的特殊噪声源。为直观详尽地描述发射系统内鱼雷出管的具体情况,本文建立了潜艇水下鱼雷安静发射普遍采用的液压平衡式发射装置内部及外部流场的有限元分析模型。基于FLUENT的动网格技术进行数值模拟,计算分析了发射过程的速度场和压力场,以及由此引起的发射流噪声特性。探讨了发射速度、发射管内外压力、潜艇航速或外部流场、水深等多种因素对鱼雷水下发射噪声的影响。     

Postsynaptic Potentials and Morphological Features of Tectal Cells in Homing Pigeons

In this study postsynaptic potentials responding to the electrical stimulation of the optic nerve and the nucleus isthmipars parvocellularis (Ipc) were intracellularly recorded from 86 tectal cells in pigeons, 13 of which were marked with Lucifer yellow (LY). According to types of postsynaptic potentials and their succesion, the postsynaptic responses could be classified into four types: excitatory postsynaptic potential (EPSP)-inhibitory postsynaptic potential (IPSP) sequence (EI type), E, I and IE types.Among them, E or EI responses were mainly produced to the optic nerve stimulation, while the electrical stimulation of the lpc elicited I responses in more than half the recorded cells.LY-marked tectal cells included five ganglionic cells, four pyramidal cells, two bipolar cells and two stellate cells.The ganglionic cells were mainly located in tectal layers Ⅲ and Ⅳ, whereas the others were in layer Ⅱ.It appears from both intracellular recordings and fluorescent markings that there is some correlati     

高频噪声干扰器对抗声自导鱼雷效果分析*

为提高潜艇对抗声自导鱼雷时机动方案的合理性,在高频噪声干扰器对抗声自导鱼雷原理分析的基础上,探讨了基于方位和能量的干扰效果分析方法。仿真分析了典型态势下噪声干扰器对主被动声自导鱼雷的干扰区域,给出了干扰扇面和自导距离缩减率随雷目距离的变化规律。结果表明,干扰噪声谱级比潜艇辐射噪声高出一定值(如15 dB)时,对被动声自导鱼雷具有较好的干扰效果,将宽带噪声功率集中到窄带中进行频率瞄准干扰,可大幅提高对抗主动声自导鱼雷的效果。该文的研究方法可为潜艇规避声自导鱼雷的机动方案提供依据。     

Silk-based nanocomplexes with tumor-homing peptides for tumor-specific gene delivery

Nanoscale complexes of recombinant silk molecules containing THPs with DNA are designed as less cytotoxic and highly target‐specific gene carriers. Genetically engineered silk proteins containing poly(L ‐lysine) domains to interact with pDNA and the THP to bind to specific tumorigenic cells for target‐specific pDNA delivery are prepared, followed by in vitro transfection into MDA‐MB‐435 melanoma cells, highly metastatic human breast tumor MDA‐MB‐231 cells, and non‐tumorigenic MCF‐10A breast epithelial cells. The silk/poly(L ‐lysine) block copolymer containing Lyp1 (ML‐Lyp1) shows significant differences from silk/poly(L ‐lysine) block copolymer containing F3 (ML‐F3) in cytotoxicity to MCF10A cells. ML‐F3 is the most promising candidate for target delivery into tumorigenic cells.

     

基于舷侧阵声纳的鱼雷远程自导性能研究

针对鱼雷的远程自导问题,研究了恶劣水文条件下浅海波导中鱼雷舷侧阵声纳对主动声纳信号的探测能力和测向精度,计算结果表明:在潜艇反舰作战中,通过利用水面舰艇发射的主动声纳信号,可实现潜射鱼雷对目标的远程被动探测,其被动测向精度一般可满足自导精度要求。     

A differential game of incomplete information

In this paper, we study a differential game of incomplete information. In such a game, the cost function depends on parameter . At the start of the game, only one of the players knows the value of this parameter, while the other player has only a (subjective) probability distribution for the parameter. We obtain explicit expressions for both the value of the game and the two players' optimal strategies.     

潜射鱼雷攻击水面舰船时的声自导发现概率仿真研究

鱼雷是潜艇攻击水面舰船的主要武器之一,潜艇发射声自导鱼雷攻击水面舰船的过程中,鱼雷的自导装置能否有效发现目标受多种因素的影响,有必要对其声自导装置发现目标的概率进行分析研究。阐述了潜艇使用声自导鱼雷对水面舰船的攻击过程,分析了水面舰船的辐射噪声和声反射强度对鱼雷声自导作用距离的影响,采用蒙特卡洛方法,对声自导鱼雷发现水面舰船的概率进行了仿真分析。仿真结果表明,在设定的仿真条件下,随着鱼雷射击距离增大、声自导作用距离变小、目标方位误差变大,潜艇使用鱼雷攻击水面舰船时的声自导发现概率会明显变小,攻击目标舷角、舰船目标航速不同时,声自导鱼雷的发现概率也不相同。潜艇在使用声自导鱼雷对水面舰船实施攻击前,应根据攻击态势、水面舰船运动规律和水文情况,预报声自导鱼雷对水面舰船目标的发现概率。     

模拟气泡幕激光近轴前向散射照度分布

从Mie散射理论出发,利用单气泡散射理论模型研究了激光前向散射特性以及激光前向散射光轴周围激光照度分布状态。选用波长为632.8 nm的激光,在不同介质和不同压强下测量并分析了气泡幕的散射光照度。研究表明,激光前向散射光主要分布在离光轴0.588的范围内,其沿激光光轴呈轴对称分布,并且沿光轴方向截面分布为高斯分布;在考虑水体自身散射时,0.006 MPa、0.008 MPa和0.010 MPa下,各个散射角被散射掉的光大概占激光前向散射照度的35%、45%和55%,可得到无论考虑水体自身散射与否,激光前向散射光与压强皆成反比。