肿瘤患者化疗后骨髓抑制的护理探讨

通过对113例化疗后骨髓抑制患者采用保护性隔离，皮肤、口腔、上呼吸道、泌尿道护理及饮食、心理等综合性护理措施的观察，发现113例化疗后骨髓抑制患者，经过综合护理措施仅13例出现感染、发热，2例经抗生素治疗无效，死于感染性休克，其余患者的血象均恢复正常，康复出院。所以本护理措施，对促进化疗后骨髓抑制患者的康复有一定的应用价值。     

基于ANP权重确定的AHP-DEA模型及其在逆向物流服务供应商选择中的应用

实际系统评价问题中,输入输出指标之间往往并非独立,而是存在着复杂的影响与反馈关系.传统AHP-DEA模型直接采用层次分析法(AHP)构造约束锥,容易使指标权重产生较大偏差甚至出现错误.通过网络分析法(ANP)确定了权重,反向构造了AHP约束锥,并与DEA模型结合,建立了AHP-DEA模型.同时,开展了逆向物流服务供应商选择应用研究,应用结果表明,基于ANP权重确定的AHP-DEA模型能够有效解决多个决策单元均有效而无法区分优劣的问题.     

Accurate free energy calculation along optimized paths

The path‐based methods of free energy calculation, such as thermodynamic integration and free energy perturbation, are simple in theory, but difficult in practice because in most cases smooth paths do not exist, especially for large molecules. In this article, we present a novel method to build the transition path of a peptide. We use harmonic potentials to restrain its nonhydrogen atom dihedrals in the initial state and set the equilibrium angles of the potentials as those in the final state. Through a series of steps of geometrical optimization, we can construct a smooth and short path from the initial state to the final state. This path can be used to calculate free energy difference. To validate this method, we apply it to a small 10‐ALA peptide and find that the calculated free energy changes in helix‐helix and helix‐hairpin transitions are both self‐convergent and cross‐convergent. We also calculate the free energy differences between different stable states of β‐hairpin trpzip2, and the results show that this method is more efficient than the conventional molecular dynamics method in accurate free energy calculation. © 2009 Wiley Periodicals, Inc. J Comput Chem, 2010     

带有因子约束锥的DEA模型

传统DEA模型将输入输出指标对评价结果的影响等同看待,与实际情况不符.学者们不断尝试运用各种方法对DEA模型中指标的权重进行约束,以体现不同指标重要性的不同.但是,目前的相关研究大多采用主观评价方法,这样会破坏DEA的客观性,而采用因子分析确定的权重是客观的,所以在DEA模型中建立因子约束锥,对权重进行约束,可以在保持DEA客观性不变的基础上体现不同指标重要性的不同.     

冗余抑制的硬件实现及作用过程分析

基于低功耗设计的要求，本文对数字系统中冗余现象的普遍性进行分析，研究了实施冗余抑制功能的各种基本结构，并进行了抑制作用的时间分析，这些均为在电路的低功耗设计中有效地应用冗余抑制技术提供了研究基础。     

Deciphering In-vivo Cross-linking Mass Spectrometry Data for Dynamic Protein Structure Analysis

Protein structure and protein-protein interactions(PPIs) are crucial for regulating cellular activities required for cell viability and homeostasis. Chemical cross-linking coupled with mass spectrometry(CXMS) has become a versatile tool providing insights into both protein structure with distance restraints and protein-protein interactions with interface sites. Cross-links as the most information-rich data in a CXMS experiment are responsible for the structural model validation and integrative modeling with high throughput and sensitivity. In this work, ensemble refinement of the existing protein structure against the in-vivo cross-linking distance restraints was performed for dynamic protein structure modeling and protein interaction binding interface building in the intracellular environment. These results indicate great potential of in-vivo CXMS data for providing a molecular basis of protein structural dynamics exploration and function performance.     

THE CHEBYSHEV SPECTRAL METHOD WITH A RESTRAINT OPERATOR FOR BURGERS EQUATION

ＴＨＥＣＨＥＢＹＳＨＥＶＳＰＥＣＴＲＡＬＭＥＴＨＯＤＷＩＴＨＡＲＥＳＴＲＡＩＮＴＯＰＥＲＡＴＯＲＦＯＲＢＵＲＧＥＲＳＥＱＵＡＴＩＯＮ￥ＭＡＨＥＰＩＮＧ；ＧＵＯＢＥＮＹＵ（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｈｅｍａｔｉｃｓ，ＳｈａｎｇｈａｉＵｎｉｖｅｒｓｉ...     

约束条件及装药直径对HMX/F2641传爆药爆压影响的实验研究

采用锰铜压力传感器法测量了约束条件和装药直径对传爆药HMX/F2641爆压的影响,传爆药密度为90%的理论密度。装药直径小于5mm时,小型化传爆序列爆压随装药直径和约束条件阻抗的减小而降低,装药直径3～5mm范围内,约束条件及装药直径对传爆药爆压的影响较小;在装药直径1.5～3mm范围内,小型化传爆序列约束条件和装药直径对传爆药爆压的影响较大。在装药密度一定时,通过装药尺寸及约束条件的匹配,可以控制并调整传爆药的爆压输出来满足不同主装药起爆的需求。     

Metallacrown ethers with a symmetric bis(phosphite) ligand derived from 1,2-bis-(2-hydroxyethoxy)benzene: Synthesis, characterization and hydroformylation of styrene

To better understand the effects of ligand configuration on hydroformylation reactions carried out in the presence of LiBPh₄·3dme (dme = 1,2-dimethoxyethane), a conformationally restrained bis(phosphite) ligand derived from 1,2-bis-(2-hydroxyethoxy)benzene, {[(2,2′-O₂C₁₂H₈)P(C₂H₄O₂)]₂C₆H₄}, 1, has been prepared and its Rh(I) metallacrown ether complex has been evaluated as a catalyst for the hydroformylation of styrene. Both the activity and regioselectivity of the catalyst are sensitive to the amount of the LiBPh₄·3dme added with the activity decreasing by 16% and the regioselectivity for the iso increasing by 9% at a 8:1 LiBPh₄:Rh ratio.Model complexes for the octahedral, cis-Mo(CO)₄(1), 2, and square planar, cis-PtCl₂(1), 3, and cis-PdCl₂(1), 4, complexes in the catalytic cycle has been have been studied using multinuclear NMR spectroscopy and X-ray crystallography. Although the X-ray crystal structure of 2 suggests that the metallacrown ether ring could adopt a configuration capable of binding alkali metal cations, this does not appear to occur in a dichloromethane-d₂ solution of 2 because no shift in the ³¹P NMR resonance 2 is observed upon the addition of an excess of LiBPh₄·3dme. The ³¹P{¹H} NMR spectra of chloroform-d solutions of 2 (in the presence of a catalytic amount of HgCl₂) and of 4 and the X-ray crystal structures of the complexes indicate that the bis(phosphite) ligands are cis coordinated in these complexes in both the solution and in the solid state. This is particularly surprising for 4 because related PdCl₂{Ph₂P(CH₂CH₂O)_nCH₂CH₂PPh₂} (n = 3-5) complexes exhibit both cis-trans and monomer-oligomer equilibria in solution.     

R~N中一(p,q)-Laplacian方程组正基态解的存在性

利用约束极小化方法研究了一类拟线性方程组,当α,β满足α+β+2>max{p,q}和(α+1)/(p*)+(β+1)/(q*)≤1时,连续函数V和W在两种情形下,正基态解的存在性.