Control of a multigroup COVID-19 model with immunity: treatment and test elimination

Nonlinear Dynamics - This paper introduces a multigroup COVID-19 model with immunity, in which the total population of each group is partitioned into five compartments, that is, susceptible,...     

Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety

Molecular Diversity - Based on the strategy of diversity-oriented synthesis and the structures of natural product pimprinine and streptochlorin, two series of novel pimprinine derivatives...     

Substituent engineering in g-C3N4/COF heterojunctions for rapid charge separation and high photo-redox activity

Science China Chemistry - The heterojunction constructed of covalent organic frameworks (COFs) with adjustable structure and other photocatalysts has great potential in the field of photocatalysis....     

Anti-fibrosis attributes: UHPLC-MS/MS-based pharmacokinetics profiling of a novel autotaxin inhibitor with excellent in vivo efficacy in rat

3,4-Difluorobenzyl(1-ethyl-5-(4-((4-hydroxypiperidin-1-yl)-methyl)thiazol-2-yl)-1H-indol-3-yl)carbamate (NAI59), a small molecule with outstanding therapeutic effectiveness to anti-pulmonary fibrosis, was developed as an autotaxin inhibitor candidate compound. To evaluate the pharmacokinetics and plasma protein binding of NAI59, a UPLC–MS/MS method was developed to quantify NAI59 in plasma and phosphate-buffered saline. The calibration curve linearity ranged from 9.95 to 1990.00 ng/mL in plasma. The accuracy was −6.8 to 5.9%, and the intra- and inter-day precision was within 15%. The matrix effect and recovery, as well as dilution integrity, were within the criteria. The chromatographic and mass spectrometric conditions were also feasible to determine phosphate-buffered saline samples, and it has been proved that this method exhibits good precision and accuracy in the range of 9.95–497.50 ng/mL in phosphate-buffered saline. This study is the first to determine the pharmacokinetics, absolute bioavailability, and plasma protein binding of NAI59 in rats using this established method. Therefore, the pharmacokinetic profiles of NAI59 showed a dose-dependent relationship after oral administration, and the absolute bioavailability in rats was 6.3%. In addition, the results of protein binding showed that the combining capacity of NAI59 with plasma protein attained 90% and increased with the increase in drug concentration.     

Benzyl alcohol oxidation and hydrogen generation over MoS2/ZnIn2S4 composite photocatalyst

Research on Chemical Intermediates - Owing to the simultaneous utilization of photogenerated electrons and holes, coupling light-driven hydrogen (H2) evolution reaction (HER) and biomass-derived...     

Multifunctional fibrous wound dressings for refractory wound healing

Refractory wounds have always been an important issue to healthcare systems, whose healing process is always delayed by multiple factors, including bacterial infections, chronic inflammation, and excessive exudates, etc. Employing multifunctional wound dressings is recognized as an effective strategy to deal with refractory wounds, which has yielded promising outcomes in recent years. Among these advanced wound dressings, fibrous dressings have gained growing attention due to their unique merits. Such wound dressings have demonstrated great potential in delivering theranostic agents, such as antibacterial agents, anti-inflammatory drugs, growth factors, and diagnostic probes, etc., for the purposes of accelerating wound healing. This paper reviews the development of multifunctional fibrous dressings and their applications in treating refractory wounds. The construction approaches of novel fibrous dressing with capabilities of antibacterial, anti-inflammation, exudate management and diagnosis were also introduced. Furthermore, the existing problems and challenges are also discussed briefly.     

COMPENSATING ROLE OF SELF-EQUILIBRATED STRESS FIELDS IN CONSTRUCTING NON-SINGULAR SOLUTIONS USING A NON-EUCLIDEAN CONTINUUM MODEL FOR AN INCOMPRESSIBLE SPHERE

Journal of Applied Mechanics and Technical Physics - A self-equilibrated stress field for an incompressible sphere is constructed based on a non-Euclidean continuum model. The...     

基于流量测点的热网变动阻力系数优化辨识

随着供热计量系统的普及，系统可以根据负荷的变化进行调整，管网的阻力系数随即发生变化。对变动阻力系数进行优化辨识是了解供热管网实时运行状况的有效手段。提出一种基于流量监测数据的供热管网变动阻力系数优化辨识方法，并利用遗传算法进行求解。对洛阳市某小区供暖季管网实际运行数据进行验证，辨识结果的相对误差在5%以内。结果表明：该方法可以在只有流量观测数据时得到精度较高的供热管网变动阻力系数，为供热系统的运行调节提供指导。     

Effect of Oil Viscosity on Hydraulic Cavitation Luminescence

Fluid Dynamics - The collapse of cavitation bubbles in a hydraulic system generates localized zones of high temperature and pressure and, under certain conditions, luminescence. In this study, we...