首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1540篇
  免费   290篇
  国内免费   133篇
化学   947篇
晶体学   9篇
力学   84篇
综合类   28篇
数学   212篇
物理学   683篇
  2023年   29篇
  2022年   21篇
  2021年   30篇
  2020年   60篇
  2019年   65篇
  2018年   49篇
  2017年   36篇
  2016年   66篇
  2015年   62篇
  2014年   78篇
  2013年   106篇
  2012年   126篇
  2011年   144篇
  2010年   81篇
  2009年   86篇
  2008年   81篇
  2007年   93篇
  2006年   93篇
  2005年   76篇
  2004年   73篇
  2003年   45篇
  2002年   39篇
  2001年   26篇
  2000年   25篇
  1999年   37篇
  1998年   33篇
  1997年   25篇
  1996年   34篇
  1995年   27篇
  1994年   27篇
  1993年   26篇
  1992年   23篇
  1991年   23篇
  1990年   19篇
  1989年   24篇
  1988年   20篇
  1987年   10篇
  1986年   8篇
  1985年   8篇
  1984年   2篇
  1983年   3篇
  1982年   2篇
  1981年   2篇
  1980年   3篇
  1979年   4篇
  1978年   2篇
  1976年   4篇
  1974年   1篇
  1973年   4篇
  1930年   1篇
排序方式: 共有1963条查询结果,搜索用时 15 毫秒
1.
Transport in Porous Media - Membrane filtration of feed containing multiple species of particles is a common process in the industrial setting. In this work, we propose a model for filtration of a...  相似文献   
2.
A Cayley graph Γ=Cay(G,S)is said to be normal if G is normal in Aut Γ.In this paper,we investigate the normality problem of the connected 11-valent symmetric Cayley graphs Γ of finite nonabelian simple groups G,where the vertex stabilizer Av is soluble for A=Aut Γ and v ∈ VΓ.We prove that either Γ is normal or G=A5,A10,A54,A274,A549 or A1099.Further,11-valent symmetric nonnormal Cayley graphs of A5,A54 and A274 are constructed.This provides some more examples of nonnormal 11-valent symmetric Cayley graphs of finite nonabelian simple groups after the first graph of this kind(of valency 11)was constructed by Fang,Ma and Wang in 2011.  相似文献   
3.
The aim of this work was to further investigate the anticancer potential of Juglans mandshurica Maxim, including the separation of active constituents and their anti-proliferative effects with underlying mechanism of action. Five alkaloids (15) were isolated from the bark of J. mandshurica. Among them, 1 showed the highest cytotoxic activities against Hep3B and HepG2 cells with an IC50 values of 61.80 and 56.24 μM, respectively. Therefore, the cellular mechanism involved 1 was subsequently studied. Our results showed that 1 markedly caused apoptosis and autophagy, but without cell cycle arrest in HepG2 cells. Interestingly, only autophagic cell death was induced in 1-treated Hep3B cells. It is concluded that the isolated alkaloids exerted a certain anti-hepatoma potential, and our results may provide a basis for the further investigation of the alkaloids extracted from J. mandshurica.  相似文献   
4.
A comprehensive understanding of the structure, self-assembly mechanism, and dynamics of one-dimensional supramolecular polymers in water is essential for their application as biomaterials. Although a plethora of techniques are available to study the first two properties, there is a paucity in possibilities to study dynamic exchange of monomers between supramolecular polymers in solution. We recently introduced hydrogen/deuterium exchange mass spectrometry (HDX-MS) to characterize the dynamic nature of synthetic supramolecular polymers with only a minimal perturbation of the chemical structure. To further expand the application of this powerful technique some essential experimental aspects have been reaffirmed and the technique has been applied to a diverse library of assemblies. HDX-MS is widely applicable if there are exchangeable hydrogen atoms protected from direct contact with the solvent and if the monomer concentration is sufficiently high to ensure the presence of supramolecular polymers during dilution. In addition, we demonstrate that the kinetic behavior as probed by HDX-MS is influenced by the internal order within the supramolecular polymers and by the self-assembly mechanism.  相似文献   
5.
The complexity of biological samples determines that the detection of a single biomolecule is unable to satisfy actual needs. Moreover, the “false positives” results caused by a single biomolecule detections easily leads to erroneous clinical diagnosis and treatment. Thus, it is important for the homogenous quantification of multiple biomolecules in not only basic research but also practical application. As a consequent, a large number of literatures have been exploited to monitor multiple biomolecules in homogenous solution, enabling facilitating the development of the disease diagnosis, treatment as well as drug discovery. One-dimensional nanomaterials and two-dimensional nanomaterials have special physical and chemical properties, such as good electrochemical properties, stable structure, large specific surface area, and biocompatibility, which are widely used in electrochemical and fluorescent detection of biomolecules. This tutorial review highlights the recent development for the detection of multiple biomolecules by using nanomaterials including one-dimensional materials (1DMs) as well as two-dimensional materials (2DMs).  相似文献   
6.
The study on the nonlocal systems is one of the hot topics in nonlinear science. In this paper, the well-known fifth-order integrable systems including the Sawada-Kotera (SK) equation, the Kaup-Kupershmidt (KK) equation and the fifth-order Koterweg-de Vrise (FOKdV) equation are extended to a generalized two-place nonlocal form, the generalised fifth-order Alice-Bob system. The Lax integrability of two sets of Alice-Bob systems for all the SK, KK and FOKdV type systems are explicitly given via matrix Lax pairs. The $\hat{P}\hat{T}$ symmetry breaking and symmetry invariant periodic and solitary waves for one set of nonlocal SK, KK and FOKdV system are investigated via a special travelling wave solution ansatz.  相似文献   
7.
Point‐of‐care detection for pathogen is of critical need for wide epidemic warning and medical diagnosis. In this work, we have designed and developed a fully portable and integrated microchip based real‐time polymerase chain reaction machine for rapid pathogen detection. The instrument consists of three functional components including heating, optical, and electrical modules, which are integrated into a portable compact box. The microchip is consumable material replaceable to meet various detection needs. Consequently, we demonstrated the outstanding performance of this portable machine for rapid detection of Salmonella and Escherichia coli O157:H7 with the advantage of time‐saving (~25 min), less samples consumption, portability, and user‐friendly operation.  相似文献   
8.
Cancer stem cells (CSCs) have been shown to be refractory to conventional therapeutic agents, can promote metastasis, and have been linked to cancer relapse. Salinomycin can selectively kill CSCs. We have shown that salinomycin derivatives accumulate in lysosomes and sequester iron in this organelle. As a result, accumulation of iron leads to the production of reactive oxygen species and lysosomal membrane permeabilization, which in turn promotes cell death by ferroptosis. These findings have revealed the prevalence of iron homeostasis in CSCs and paved the way toward the development of next-generation therapeutics.  相似文献   
9.
Differentiation of biologically important thiols, such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) is still a challenging task. Herein, we present a novel fluorescent chemodosimeter capable of selectively detecting Cys over other biothiols including Hcy and GSH and other amino acids by a facile thiol‐Michael addition/transcyclization rearrangement cascade click process. The unique transcyclization step is critical for the selectivity as a result of the kinetically favorable formation of a six‐membered ring with the Cys Michael adduct. Moreover, the probe adopts a distinctive dual quenching mechanism—photoinduced electron transfer (PET) and photoinduced intramolecular charge transfer (ICT) to deliver a drastic turn‐on fluorescence response only at the Cys‐selective transcylization step. The judicious selection of strong electron‐withdrawing naphthalimide fluorophore with maleimide group enhances the electrophilicity and thus reactivity for the cascade process leading to fast detection and ultrasensitivity with a detection limit of 2.0 nm (S/N=3). The probe has demonstrated its practical utility potential in Cys imaging in live cells.  相似文献   
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号