Targeting the cytochrome bc1 complex for drug development in M. tuberculosis: review

Molecular Diversity - The terminal oxidases of the oxidative phosphorylation pathway play a significant role in the survival and growth of M. tuberculosis, targeting these components lead to...     

Development and validation of consensus machine learning-based models for the prediction of novel small molecules as potential anti-tubercular agents

Molecular Diversity - Tuberculosis (TB) is an infectious disease and the leading cause of death globally. The rapidly emerging cases of drug resistance among pathogenic mycobacteria have been a...     

Chemically reactive and radiative von Kármán swirling flow due to a rotating disk

A new mathematical model is presented to study the heat and mass transfer characteristics of magnetohydrodynamic (MHD) Maxwell fluid flow over a convectively heated stretchable rotating disk. To regulate the fluid temperature at the surface, a simple isothermal model of homogeneous-heterogeneous reactions is employed. The impact of nonlinear thermal radiative heat flux on thermal transport features is studied. The transformed nonlinear system of ordinary differential equations is solved numerically with an efficient method, namely, the Runge-Kutta-Felberg fourth-order and fifth-order (RKF45) integration scheme using the MAPLE software. Achieved results are validated with previous studies in an excellent way. Major outcomes reveal that the magnetic flux reduces the velocity components in the radial, angular, and axial directions, and enhances the fluid temperature. Also, the presence of radiative heat flux is to raise the temperature of fluid. Further, the strength of homogeneous–heterogeneous reactions is useful to diminish the concentration of reaction.     

Piperazine‐functionalized nickel ferrite nanoparticles as efficient and reusable catalysts for the solvent‐free synthesis of 2‐amino‐4H‐chromenes

Piperazine‐functionalized nickel ferrite (NiFe₂O₄) nanoparticles were synthesized as recoverable heterogeneous base catalysts using a routine method. The synthesized materials were characterized using various spectroscopic techniques such as infrared, X‐ray diffraction, scanning electron microscopy, energy‐dispersive X‐ray, thermogravimetry analysis, and vibrating sample magnetometry. Catalytic efficiency was investigated in the synthesis of 2‐amino‐4H‐chromene derivatives via a one‐pot three component reaction of aldehyde and malononitrile with β or α‐naphthol/5‐methyle resorcinol under solvent‐free conditions with good to high yields. This method is operationally simple and has several advantages such as good to high yield, short reaction times, solvent‐free conditions, and easy synthesis. Moreover, the catalyst was recovered easily using an external magnet and reused three times without distinctive loss in catalytic activity.     

Investigations of Viscous Dissipation in Stagnation Point Flow Past a Stretchable Riga Wall: Modern Analysis of Heat Transport

This article scrutinizes the features of viscous dissipation in the stagnation point flow past through a linearly stretched Riga wall by implementing Cattaneo-Christov heat flux model. Viscous dissipation is carried out in Cattaneo-Christov diffusion analysis for the first time in this letter. As a result of Cattaneo-Christov model, some extra terms of viscous dissipation are appeared in the energy equation. These extra terms of viscous dissipation are missing in the literature. On the utilization of suitable transformations, the equations governing the problem are reduced under the boundary layer approximation into the non-linear and dimensionless ordinary differential equations. Convergent approach is utilized to solve the dimensionless governing equations. The solution thus acquired is used to highlight the effects of emerging parameters on velocity distribution and fluid's temperature through the graphs. Features of the drag force (or skin friction co-efficient) are graphically interpreted. It is noticed that the presence of modified Hartman number helps to reduce the fluid's temperature but enhances the velocity profile. Further an enlargement in the value of thermal time relaxation parameter helps to decrease the temperature distribution.     

Optimization of cadmium adsorption from aqueous solutions by functionalized graphene and the reversible magnetic recovery of the adsorbent using response surface methodology

Novel functionalized graphene adsorbent was prepared and characterized using different techniques. The prepared adsorbent was applied for the removal of cadmium ions from aqueous solution. A response surface methodology was used to evaluate the simple and combined effects of the various parameters, including adsorbent dosage, pH, and initial concentration. Under the optimal conditions, the cadmium removal performance of 70% was achieved. A good agreement between experimental and predicted data in this study was observed. The experimental results revealed of cadmium adsorption with high linearity follow Langmuir isotherm model with maximum adsorption capacity of 502 mg g^?1, and the adsorption data fitted well into pseudo‐second order model. Thermodynamic studies showed that adsorption process has exothermic and spontaneous nature. The recommended optimum conditions are: cadmium concentration of 970 mg L^?1, adsorbent dosage of 1 g L^?1, pH of 6.18, and T = 25 °C. The magnetic recovery of the adsorbent was performed using a magnetic surfactant to form a noncovalent magnetic functionalized graphene. After magnetic recovery of the adsorbent both components (adsorbent and magnetic surfactant) were recycled by tuning the surface charges through changing the pH of the solution. Desorption behavior studied using HNO₃ solution indicated that the adsorbent had the potential for reusability.     

Facile,one-pot,four-component synthesis of a new series of imidazo[1,2-a]pyridines in presence of TPAB in EtOH under reflux conditions

Research on Chemical Intermediates - A convenient, regioselective, novel, and elegant one-pot, four-component reaction was designed for synthesis of a series of new of imidazo[1,2-a]pyridines using...     

Nanosecond Pulse Generation with Silver Nanoparticle Saturable Absorber

Nanosecond pulse generation in an erbium-doped fiber laser (EDFL) passively mode-locked by a silver nanoparticle(SNP)-based saturable absorber(SA) is experimentally demonstrated. The SA is fabricated by depositing a nanosized SNP layer onto the surface of polyvinyl alcohol film through the thermal evaporation process. By inserting the SA into an EDFL cavity, stable mode-locked operation is achieved at 1561.5 nm with the maximum pulse energy up to 52.3 nJ. The laser operates at a pulse repetition frequency of 1.0 MHz with a pulse width of 202 ns. These results suggest that SNPs could be developed as an effective SA for mode-locking pulse generation.     

Optimization and sensitivity analysis of magneto-hydrodynamic natural convection nanofluid flow inside a square enclosure using response surface methodology

This article studies buoyancy-driven natural convection of a nanofluid affected by a magnetic field within a square enclosure with an individual conductive pin fin. The effects of electromagnetic forces, thermal conductivity, and inclination angle of pin fin were investigated using non-dimensional parameters. An extensive sensitivity analysis was conducted seeking an optimal heat transfer setting. The novelty of this work lies in including different contributing factors in heat transfer analysis, rigorous analysis of design parameters, and comprehensive mathematical analysis of solution domain for optimization. Results showed that magnetic strength diminished the heat transfer efficacy, while higher relative thermal conductivity of pin fin improved it. Based on the problem settings, we also obtained the relative conductivity value in which the heat transfer is optimal. Higher sensitivity of heat transfer was, though, noticed for both magnetic strength and fin thermal conductivity in comparison to fin inclination angle. Further studies, specifically with realistic geometrical configurations and heat transfer settings, are urged to translate current findings to industrial applications.