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Electro-acupuncture (EA) applied to both legs for 30min raised the tail flick latencyof the rat significantly. This effect of EA analgesia became attenuated and finally disap-peared after repeated EA stimulations, which was termed EA tolerance. EA tolerance and itscross tolerance to morphine analgesia were found to be partially reversed by intracerebro-ventricular injection of 5-hydroxytryptophan (5-HTP), the precursor of 5-hydroxytryptamine(5-HT). However, there was no depletion in cerebral 5-HT, nor was there decrease ofthe number of 5-HT receptors in the brain of the EA tolerant animals. Results obtainedfrom different lines of analysis point to the conclusion that development of tolerance toprofoundly released 5-HT during prolonged EA stimulation may constitute one of themechanisms for EA tolerance. 相似文献
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Two-dimensional transition metal dichalcogenides heterostructures have stimulated wide interest not only for the fundamental research,but also for the application of next generation electronic and optoelectronic devices.Herein,we report a successful two-step chemical vapor deposition strategy to construct vertically stacked van der Waals epitaxial In2Se3/MoSe2 heterostructures.Transmission electron microscopy characterization reveals clearly that the In2Se3 has well-aligned lattice orientation with the substrate of monolayer MoSe2.Due to the interaction between the In2Se3 and MoSe2 layers,the heterostructure shows the quenching and red-shift of photoluminescence.Moreover,the current rectification behavior and photovoltaic effect can be observed from the heterostructure,which is attributed to the unique band structure alignment of the heterostructure,and is further confirmed by Kevin probe force microscopy measurement.The synthesis approach via van der Waals epitaxy in this work can expand the way to fabricate a variety of two-dimensional heterostructures for potential applications in electronic and optoelectronic devices. 相似文献
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