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1.
Meropenem, a representative β-lactam antibiotic, is widely used to treat complicated and serious infections. Therefore, it is of great significance to monitor the plasma drug concentration for individualized antimicrobial therapy. This study first describes the development and validation of high-performance liquid chromatography–tandem mass spectrometry cubed method for monitoring meropenem in human plasma. Protein precipitation with methanol and a chromatographic analysis time of 7 min make this method simple and of high throughput. Meropenem was extracted from human plasma with recoveries >94.1%. Calibration curves were linear (R> 0.995) in the concentration range of 0.5–50 μg/mL. Overall accuracy and precision did not exceed 8.0% as well as no significant matrix effect was observed. The novelty of this method is that the triple-stage mass spectrometry technology improves the selectivity and sensitivity. A comparison of the presented method and traditional liquid chromatography–tandem mass spectrometry method was assessed in 44 patients treated with meropenem and Passing–Bablok regression coefficients and Bland–Altman plots showed that no significant difference between the two methods. So the triple-stage mass spectrometry method developed in this study is appropriate and practical for the monitor of meropenem in the daily clinical laboratory practice.  相似文献   
2.
The rational designability and chemical tunability of metal-organic frameworks(MOFs)are enabling tributes to efficaciously enhance their room temperature phosphorescence(RTP)performance.A family of stable anionic MOFs,[Zn2(4,5-ImDC)2]M2(NKU-132,M=(CH3)2NH2or(CH2CH3)2NH2),featuring significant RTP have been synthesized.By rational cation selection and in-situ replacement from dimethylammonium to diethylammonium,the phosphorescence lifetime is increased from 30.88 to126.3 ms,along with less sensitivity to air.This work provides an anti-quenching and lifetime tuning example for RTP-MOFmaterials via facile host-guest chemistry.  相似文献   
3.
分子构象的聚类是搜索分子动力学模拟轨迹中代表构象的主要方法。 它是分析复杂构象改变或分子间相互作用机制的关键步骤. 作为一种基于密度的聚类算法,密度峰值搜索算法因其聚类的准确度而被应用于分子聚类过程中. 但随着模拟时长的增长,密度峰值搜索算法较低的计算效率限制了其应用的可能. 本文提出K-means密度峰值搜索算法的聚类算法,它是密度峰值搜索算法在计算效率方面的一个扩展版本,用于解决密度峰值搜索算法中巨大的资源消耗问题. 在K-means密度峰值搜索算法中,首先,通过高效的聚类算法(例如K-means)进行初始聚类,得到的聚类中心被定义为具有权重的典型点. 然后,对加权的典型点通过密度峰值搜索算法实现二次聚类,并细化点为核心点、边界点、加细光晕点. 在与密度峰值搜索算法具有相似的精度的同时,计算复杂度由O(n2)降至O(n). 通过二面角,二级结构,关联图描述的分子构象,将KFDP用于多个模拟轨迹的聚类过程中. 并通过与K-means聚类算法,DBSCAN聚类算法的比较结果,验证了K-means密度峰值搜索算法的优势.  相似文献   
4.
Herein, we investigated the analytical features of potentiometric immunosensors for detection of alpha-fetoprotein (AFP) in hepatocellular carcinoma at different electrodes, such as carbon fiber microelectrode (CFME) and carbon-disk electrode (CDE), respectively. To construct such an immunosensor, anti-AFP capture antibodies were first conjugated covalently onto the activated electrodes through typical carbodiimide coupling. Thereafter, one-step immunoreaction protocol was successfully introduced to develop a new potentiometric immunoassay upon addition of AFP. Accompanying the antigen-antibody reaction, the surface charges of the modified electrodes were changed for the readout of electric potential. Results indicated that the linear range of CDE-based immunosensor was 0.1–100 ng mL−1 AFP, whereas the assay sensitivity by using CFME could be further increased to 3.2 pg mL−1 with the linear range from 0.01 to 500 ng mL−1 AFP. Meanwhile, CFME-based immunosensor showed high sensitivity, good reproducibility and specificity, and could be utilized for the analysis of human serum specimens with consistent results relative to commercialized ELISA kit.  相似文献   
5.
DNA methyltransferase (DNA MTase) can act as biomarker for many diseases and it is important to develop some new methods for sensitive detection of DNA MTase. In this work, a highly efficient electrochemiluminescence (ECL) sensor had been designed for detection of DNA MTase based on Ru(phen)32+ loaded double strand DNA (dsDNA- Ru(phen)32+) as signal tags. Ru(phen)32+ had been efficiently embed in the dsDNA produced through a simple hybridization chain reaction. First, a hairpin probe was designed, which can be specifically recognized by Dam MTase and modified with -SH at one end. It was modified on the surface of gold electrode by -SH as an immobilization probe (IP). This IP will be methylated in the present of Dam MTase and digested by DpnI following. Results in the release of capture probe (CP) which remains on the surface of gold electrode. The CP can hybridize with the single stand part of the dsDNA- Ru(phen)32+ and make the immobilization of ECL tags on the electrode surface, which results in a strong ECL signals detected. However, without the effect of Dam MTase, the hairpin structure of IP remains stable and cannot capture signal tags, and can only detecte weak ECL signals. The biosensor can detect the activity of Dam MTase in the concentration range of 0.01 U/mL to 20 U/mL with the ECL intensity and the logarithm of the concentration have a linear relationship, and the detection limit is calculated to be 7.6 mU/mL. The developed sensor has the ability to specifically detect Dam MTase, which can be differentiated from other types of DNA MTase. In addition, the designed method has good applicability to detect Dam MTase activity in serum samples and been applied to detect its inhibitor with high efficiency.  相似文献   
6.
Acta Mathematica Sinica, English Series - For a finite group G, the power graph $$\cal{P}(G)$$ is a simple connected graph whose vertex set is the set of elements of G and two distinct vertices x...  相似文献   
7.
Qin  Kaiwei  Guo  Lei  Ming  Shujun  Zhang  Shoute  Guo  Yanbin  Pang  Lei  Li  Tao 《Catalysis Surveys from Asia》2022,26(2):115-128
Catalysis Surveys from Asia - The catalytic performances and mechanism differences of model catalysts Cu–SSZ-13 and Fe–SSZ-13 with similar metal content and Si/Al ratio were compared....  相似文献   
8.
As one of the most attractive non-radiative power transfer mechanisms without cables,efficient magnetic resonance wireless power transfer(WPT)in the near field has been extensively developed in recent years,and promoted a variety of practical applications,such as mobile phones,medical implant devices and electric vehicles.However,the physical mechanism behind some key limitations of the resonance WPT,such as frequency splitting and size-dependent efficiency,is not very clear under the widely used circuit model.Here,we review the recently developed efficient and stable resonance WPT based on non-Hermitian physics,which starts from a completely different avenue(utilizing loss and gain)to introduce novel functionalities to the resonance WPT.From the perspective of non-Hermitian photonics,the coherent and incoherent effects compete and coexist in the WPT system,and the weak stable of energy transfer mainly comes from the broken phase associated with the phase transition of parity-time symmetry.Based on this basic physical framework,some optimization schemes are proposed,including using nonlinear effect,using bound states in the continuum,or resorting to the system with high-order parity-time symmetry.Moreover,the combination of non-Hermitian physics and topological photonics in multi-coil system also provides a versatile platform for long-range robust WPT with topological protection.Therefore,the non-Hermitian physics can not only exactly predict the main results of current WPT systems,but also provide new ways to solve the difficulties of previous designs.  相似文献   
9.
Transferring entangled states between matter qubits and microwave-field (or optical-field) qubits is of fundamental interest in quantum mechanics and necessary in hybrid quantum information processing and quantum communication. We here propose a way for transferring entangled states between superconducting qubits (matter qubits) and microwave-field qubits. This proposal is realized by a system consisting of multiple superconducting qutrits and microwave cavities. Here, „qutrit” refers to a three-level quantum system with the two lowest levels encoding a qubit while the third level acting as an auxiliary state. In contrast, the microwave-field qubits are encoded with coherent states of microwave cavities. Because the third energy level of each qutrit is not populated during the operation, decoherence from the higher energy levels is greatly suppressed. The entangled states can be deterministically transferred because measurement on the states is not needed. The operation time is independent of the number of superconducting qubits or microwave-field qubits. In addition, the architecture of the circuit system is quite simple because only a coupler qutrit and an auxiliary cavity are required. As an example, our numerical simulations show that high-fidelity transfer of entangled states from two superconducting qubits to two microwave-field qubits is feasible with present circuit QED technology. This proposal is quite general and can be extended to transfer entangled states between other matter qubits (e.g., atoms, quantum dots, and NV centers) and microwave- or optical-field qubits encoded with coherent states.  相似文献   
10.
郭敬  张玉杰 《应用光学》2022,43(5):879-885
目前的节能照明控制算法仍有陷入局部最优的问题。为了寻求全局最优解,提高室内照明的节能效果,设计一种遗传模拟退火算法对照明系统的控制参数进行优化求解。该算法通过在遗传操作后对优秀个体进行模拟退火处理,增强了算法的局部搜索能力。根据迭代的次数和种群的适应度对遗传概率进行自适应调节,使得算法在前期丰富种群多样性,避免算法“早熟”。提出基于人工神经网络的照度模型来计算室内照度分布,对照明舒适度进行评估,为构造优化算法的适应函数提供了依据。通过仿真实验,在本文介绍的照明场景应用遗传模拟退火算法,并与传统粒子群算法和遗传算法进行比较,其照明节能性能分别高出5.30%和13.61%。  相似文献   
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