A numerical simulation of photothermal response in laser medicine

In this paper, we reported a numerical solution of laser induced thermal effect in the bio-tissue. The model of photothermal effect and classical Pennes bio-heat transfer equation were introduced. Finite element method (FEM), which was realized by Matlab software, was used to calculate the temperature distribution. He-Ne laser (633 nm) was used to simulate the physical therapy in in vivo skin tissue. Under the cylinder coordinates, the three-dimension(3-D) geometry of tissue was reduced to two-dimension(2-D)computation. The results contained the radial, axial and temperature 3-D color plot. Combining the time animation display was possible. By changing the laser and tissue parameters we can get different results.This will be the initial and indispensable work of the non-destructive evaluation of the laser induced injury.     

激光医学中热响应的遥测技术研究

采用辐射温度测量技术实现了激光与生物组织热响应的无损监测.便携式红外辐射监测仪内置LD红光指示和对准音提示,在距离红外透镜25 mm处最小物面孔径为2.5 mm.靶点组织的温升变化是激光输出参量和被测生物组织自身的光、热物理特性的综合反映,与可能产生的疗效密切相关.实验记录了单个红宝石激光脉冲、连续CO2激光作用下多种组织的热响应过程,从辐照时间、温升峰值、上升时间等角度讨论了不同组织、不同条件下组织热响应的差异.     

A numerical simulation of photothermal response in laser medicine

In this paper, we reported a numerical solution of laser induced thermal effect in the bio-tissue. The model of photothermal effect and classical Pennes bio-heat transfer equation were introduced. Finite element method (FEM), which was realized by Matlab software, was used to calculate the temperature distribution. He-Ne laser (633 nm) was used to simulate the physical therapy in in vivo skin tissue. Under the cylinder coordinates, the three-dimension(3-D) geometry of tissue was reduced to two-dimension(2-D)     

采用AOTF技术的新型红外单色系统的研制

概述了声光可调谐滤光器 (AOTF)的基本色散原理 ,介绍了以AOTF为色散元件的红外单色系统的组成。对光源准直系统和系统工作距离进行了分析讨论。对DDS的使用以及DDS与DSP之间接口设计进行了介绍。理论和实验表明 ,输出红外光波数与驱动频率成良好线性关系。系统输出红外光波长范围 2 5～ 5 0 μm ,光谱半宽度为 15nm     

Photothermal damage prediction of laser interstitial thermotherapy

An improved scattering optical model was developed under cylindrical coordinate to simulate the thermal effect of diffusing applicator in laser interstitial thermotherapy (LITT). The thermal damage was calculated by finite element method (FEM) using Pennes bio-heat transfer equation and Arrhenius injury integral formula. The numerical results showed that the scattering can considerably influence the evaluation of the lesion area, and the relationship between application powers or time and resulting tissue thermal damage was nonlinear. Although usually applying relatively low power can avoid tissue charring, rather higher power is recommended because it is indispensable to achieve necessary damage threshold and the therapy time can be shortened.     

便携式紫外-可见分光光度计的设计

介绍了一种便携式紫外-可见分光光度计的设计方法, 该方法采用平场凹面全息光栅及Hamamatsu图像传感器S3904-1024Q为核心设计了小型化的色散系统;将多股光纤的一端排列成长方形直接作为入射狭缝, 解决了光谱带宽与光源能量利用率之间矛盾的问题;采用触摸屏作为仪器的输入与输出设备及集成化的小型光纤光源作为仪器的光源. 实验结果表明, 采用该种方法设计的紫外-可见分光光度计体积小(190 mm×170 mm×100 mm)、操作简单(触摸屏操作)、可以多波长同时在线测量、技术指标符合国家标准.     

激光医学中热响应的遥测技术研究

采用辐射温度测量技术实现了激光与生物组织热响应的无损监测.便携式红外辐射监测仪内置LD红光指示和对准音提示，在距离红外透镜25 mm处最小物面孔径为2.5 mm.靶点组织的温升变化是激光输出参量和被测生物组织自身的光、热物理特性的综合反映，与可能产生的疗效密切相关.实验记录了单个红宝石激光脉冲、连续CO2激光作用下多种组织的热响应过程，从辐照时间、温升峰值、上升时间等角度讨论了不同组织、不同条件下组织热响应的差异.     

傅里叶变换光谱学相位校正的新方法

本文提出一种校正干涉图不对称性的新方法.采用本方法进行一次处理,就可把严重失对称的干涉图变成对称,从而可校正因相位误差而造成的复原光谱畸变.理论和实验都证明此方法比目前通用的各种相位校正方法有更好的效果.     

鲜红斑痣光谱测定系统与临床实验

对进行激光治疗的鲜红斑痣患者的皮肤进行光谱定量分析,有利于正确分析患者病变皮肤的光学特性、调整手术设备的工作参数和提高激光治疗的效果.基于对鲜红斑痣形成机理分析及激光临床治疗过程观察,文章建立了一套自动数据采集和分析的光谱系统,可以用于测定鲜红斑痣皮肤微区在380～780 nm范围内的光谱,光谱分辨率为1 nm.实验可测定不同年龄、不同色素痣的光谱曲线,分析并讨论了影响系统工作的原因和解决方法.