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Environmental Impacts on Spiking Properties in Hodgkin-Huxley Neuron with Direct Current Stimulus 下载免费PDF全文
Based on the well accepted Hodgkin-Huxley neuron model, the neuronal intrinsic excitability is studied when the neuron is subject to varying environmental temperatures, the typical impact for its regulating ways. With computer simulation, it is found that altering environmental temperature can improve or inhibit the neuronal intrinsic excitability so as to influence the neuronal spiking properties. The impacts from environmental factors can be understood that,the neuronal spiking threshold is essentially influenced by the fluctuations in the environment. With the environmental temperature varying, burst spiking is realized for the neuronal membrane voltage because of the environment-dependent spiking threshold. This burst induced by changes in spiking threshold is different from that excited by input currents or other stimulus. 相似文献
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It is well known that potassium ion channels have higher permeability than K ions, and the permeable rate of a single K ion channel is about 108 ions per second. We develop a hierarchical model of potassium ion channel permeation involving ab initio quantum calculations and Brownian dynamics simulations, which can consistently explain a range of channel dynamics. The results show that the average velocity of K ions, the mean permeable time of K ions and the permeable rate of single channel are about 0.92nm/ns, 4.35ns and 2.30 ×10^8 ions/s, respectively. 相似文献
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Supplementary Material: A Dynamic Model of Heavy Ion ~7Li Irradiation Mutagenesis Based on Maize Inbred Line Nutrition Difference 下载免费PDF全文
正Text A:Irradiation mutagenesis Heavy ion ~7Li radiation mutagenesis was performed by the HI-13 tandem accelerator at the China Institute of Atomic Energy.The radiation procedure was configured as previously described,with a 相似文献
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肌球蛋白Ⅵ分子马达因其特殊的结构及胞内功能,其动力学原理成为研究的热点. 从肌球蛋白Ⅵ自身结构和实验现象出发,建立其弹性扩散模型,并通过Monte Carlo方法分析了肌球蛋白Ⅵ满足朗之万方程的随机动力学行为. 结果表明,在环境噪声作用下,具有弹性势能和轨道周期势能的肌球蛋白Ⅵ可以进行梯跳运动和有效的输运,但负载力会减弱分子马达系统的输运能力;当弹性系数一定时,弹性链越长平均速度越小,当弹性链长度一定时,合理选择弹性系数平均速度可达到最大值;另外,负载力的存在使肌球蛋白Ⅵ在接触位点的平均驻留时间呈指数增加.
关键词:
分子马达
肌球蛋白Ⅵ
朗之万方程
弹性扩散模型 相似文献
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F1-ATPase, a part of ATP synthase, can synthesize and hydrolyze ATP moleculars in which the central γ-subunit rotates inside the α3β3 cylinder. A stochastic four-state mechanochemical coupling model of F1-ATPase is studied with the aid of the master equation. In this model, the ATP hydrolysis and synthesis are dependent on ATP, ADP, and Pi concentrations. The effects of ATP concentration, ADP concentration, and the external torque on the occupation probability of binding-state, the rotation rate and the diffusion coefficient of F1-ATPase are investigated. Moreover, the results from this model are compared with experiments. The mechanochemical mechanism F1-ATPase is qualitatively explained by the model. 相似文献
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提出了布朗马达的非均匀高斯跃迁理论,用布朗粒子在多态之间的跃迁模型描述分子马达的定向运动.假定跃迁速率与位置有关,且在跃迁点附近具有高斯函数形式,将布朗粒子在x处的概率密度Pm(x,t)在跃迁点附近展开,可以进行任意阶的近似计算.这一理论涵盖了以往的定点跃迁模型和均匀跃迁模型.作为具体例子,研究了系统在两态之间的跃迁问题.假定在一个周期内有两个跃迁点,讨论了布朗粒子定向运动产生的概率流随温度、跃迁速率和
跃迁宽度的变化关系.
关键词:
布朗马达
高斯跃迁
概率流 相似文献
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在电离辐射速率理论的基础上, 结合电离辐射诱导植物的微观与宏观生物效应, 建立了电离辐射致植物诱变效应的损伤-修复模型. 通过对理论模型平衡态的数值求解, 研究了辐照植物各状态相对浓度随电离辐射剂量的变化. 研究表明当考虑植物的修复作用时, 理论模型能够给出“马鞍型”的植物存活率-剂量关系. 为进一步验证模型, 对重离子7Li辐射玉米自交系的实验数据进行理论模型拟合, 确定重离子辐射玉米的诱变效应参数, 理论计算的结果与实验数据符合较好. 电离辐射诱导植物的损伤-修复模型的建立为电离辐射诱导植物生物效应的机理研究和辐射诱变植物育种提供了理论依据和参考. 相似文献