Controlling intracellular Ca2+ spiral waves by the local agonist in the cell membrane

A modified spatially extended Tang-Othmer Ca2+ model is used to study intracellular Ca2+ spiral waves numerically.It is found that,as a local stimulation,the local agonist-binding on the cell membrane,which enhances the local concentration of the messenger molecule inositol 1,4,5-trisphosphate(IP 3),can influence the dynamics of the spiral waves.1) Strong enough stimuli can change the spiral wave from a meandering to a rigidly rotating one.2) On the other hand,strong enough stimuli can suppress the spiral wave from the system.It provides the theoretical clue for controlling the spiral waves by stimulating the cell membrane.     

速度限制对交通流的影响

运用元胞自动机模型研究单车道路面上设立限速区对交通流的影响.计算机模拟结果显示,在交通流与密度的基本图中存在饱和交通流量,其大小取决于限速区的最大速度.限速区的设立导致不同相的分离.在确定性的模型中,当车辆密度较低时,存在两种不同的自由流相;而当车辆密度较高时,出现最大交通流相和自由流相.在随机模型中,车辆密度较高时,出现最大交通流相-堵塞相-自由流.对交通流以及临界密度等量给出一些解析结果.     

Electron Beam Lithographic Pixelated Micropolarizer Array for Real-Time Phase Measurement

Pixelated micropolarizer arrays （PMAs） have recently been used as key components to achieve real-time phase measurement. PMA fabrication by electron beam lithography and inductively coupled plasma-reactive ion etching is proposed in this work. A 320 × 240 aluminum PMA with 7.4 μm pitch is successfully fabricated by the proposed technique. The period of the grating is 140nm, and the polarization directions of each of the 2 × 2 units are 0°, 45°, 90°, and 135°. The scanning electron microscopy and optical microscopy results show that the PMA has a good surface characteristic and polarization performances. When the PMA is applied to phase-shifting interferometry, four fringe patterns of different polarization directions are obtained from only one single frame image, and then the object wave phase is calculated in real time.     

反应限制聚集模型的动力学行为的研究

根据反应限制聚集（reaction limited aggregation, RLA）模型,研究表面活性剂存在时 的薄膜外延生长动力学过程. 研究结果表明,在二维岛的生长初期,分形岛与紧致岛具有不 同的岛密度和“死”原子密度（岛的相对总面积）增长方式：分形岛密度随覆盖率生长指数 小于1,紧致岛密度的生长指数大于1;分形岛相对总面积随覆盖率线性增长,紧致岛相对总 面积随覆盖率非线性增长. 关键词： 反应限制聚集模型 岛密度 “死”原子密度     

像素偏振片阵列制备及其在偏振图像增强中的应用

像素偏振片阵列在实时测量光的斯托克斯参量方面具有重要的应用.本文设计和制作了基于金属铝纳米光栅的像素偏振片阵列,制作工艺基于电子束曝光技术.偏振片阵列单元尺寸为7.4μm,每相邻2×2单元的透偏振方向分别为0,7π/4,π/2和3π/4.光栅周期为140 nm,占空比为0.5,深度100 nm,光栅面型为矩形.像素偏振片阵列的扫描电子显微镜照片显示,制备的偏振片阵列的金属纳米光栅栅线无断线、无交叉、无杂物污染,光栅栅线结构平直,厚度均匀,满足理想矩形面型.采用偏振光作为照明光的光学显微镜拍摄图片显示,像素偏振片阵列整体形状规则,具有很好的偏振特性,最大偏振透射率可达到79.3%,消光比可达到454.将像素偏振片阵列与CCD(charge coupled device)集成在一起,采集单帧图像即可计算图像的斯托克斯参量,从而得到拍摄物体线偏振度图像和线偏振角图像,实现了偏振增强,可应用于目标反隐和识别.     

Effects of time delays in a mathematical bone model

In this paper we propose a mathematical model of bone remodeling with time delays of both osteoclast-derived paracrine signaling of tumor and tumor-derived paracrine signaling of osteoclast. The effects of time delays on the growth of tumor cells and bone system are studied in multiple myeloma-induced bone disease. In the case of small osteoclast-derived paracrine signaling, it is found that the growth of tumor cells slows down, the oscillation period of the ratio of osteoclasts to osteoblasts is extended with increasing time delay, and there is a competition between the delay and osteoclast-derived paracrine signaling. In the case of large tumor-derived paracrine signaling, the tumor-derived paracrine signaling can induce a more significant decline in tumor growth for long time delay, and thus slowing down the progression of bone disease. There is an optimal coupling between the tumor-derived paracrine signaling of osteoclasts and time delay during the progressions of bone diseases, which suppresses the tumor growth and the regression of bone disease.