Analysis of a new multispecies tumor growth model coupling 3D phase-fields with a 1D vascular network

In this work, we present and analyze a mathematical model for tumor growth incorporating ECM erosion, interstitial flow, and the effect of vascular flow and nutrient transport. The model is of phase-field or diffused-interface type in which multiple phases of cell species and other constituents are separated by smooth evolving interfaces. The model involves a mesoscale version of Darcy’s law to capture the flow mechanism in the tissue matrix. Modeling flow and transport processes in the vasculature supplying the healthy and cancerous tissue, one-dimensional (1D) equations are considered. Since the models governing the transport and flow processes are defined together with cell species models on a three-dimensional (3D) domain, we obtain a 3D–1D coupled model.     

Quasi-linear PDEs and forward–backward stochastic differential equations: Weak solutions

In this paper, we study the existence, uniqueness and the probabilistic representation of the weak solutions of quasi-linear parabolic and elliptic partial differential equations (PDEs) in the Sobolev space $H_{\rho }^1({\mathbb{R}}^d)$. For this, we study first the solutions of forward–backward stochastic differential equations (FBSDEs) with smooth coefficients, regularity of solutions and their connection with classical solutions of quasi-linear parabolic PDEs. Then using the approximation procedure, we establish their convergence in the Sobolev space to the solutions of the FBSDES in the space $L_{\rho }^2({\mathbb{R}}^d;{\mathbb{R}}^d)?L_{\rho }^2({\mathbb{R}}^d;{\mathbb{R}}^k)?L_{\rho }^2({\mathbb{R}}^d;{\mathbb{R}}^{k\times d})$. This gives a connection with the weak solutions of quasi-linear parabolic PDEs. Finally, we study the unique weak solutions of quasi-linear elliptic PDEs using the solutions of the FBSDEs on infinite horizon.     

Fixed Points,Continuous Selections,and Existence of Solution of Optimization-Related Problems

We propose a definition of a generalized type of Knaster–Kuratowski–Mazurkiewicz (KKM) mappings, called a weak T-KKM mapping, and a corresponding weak KKM property. A new extension of the Fan–Glicksberg fixed-point theorem is established. Sufficient conditions for the existence of a continuous selection, a fixed point of a composition, and a coincidence point are also provided. Then, we use the obtained results to study the existence of solutions to various optimization-related problems. Discussions and detailed examples are included as well to compare our results with existing ones and to explain their advantages in many situations.     

Qualitative theory for Volterra difference equations

We investigate l^p boundedness, the topological structure of solutions set and the asymptotic periodicity of Volterra functional difference equations. The theoretical results are complemented with a set of applications.     

A continuum of periodic solutions to the planar four-body problem with two pairs of equal masses

In this paper, we apply the variational method with Structural Prescribed Boundary Conditions (SPBC) to prove the existence of periodic and quasi-periodic solutions for the planar four-body problem with two pairs of equal masses $m_1=m_3$ and $m_2=m_4$. A path $q(t)$ on $[0,T]$ satisfies the SPBC if the boundaries $q(0)\in \mathbf{A}$ and $q(T)\in \mathbf{B}$, where A and B are two structural configuration spaces in ${({\mathbf{R}}^2)}^4$ and they depend on a rotation angle $\theta \in (0,2\pi )$ and the mass ratio $\mu =\frac{m_2}{m_1}\in {\mathbf{R}}^{+}$.We show that there is a region $\mathrm{\Omega }?(0,2\pi )\times R^{+}$ such that there exists at least one local minimizer of the Lagrangian action functional on the path space satisfying the SPBC $\{q(t)\in H^1([0,T],{({\mathbf{R}}^2)}^4)|q(0)\in \mathbf{A},q(T)\in \mathbf{B}\}$ for any $(\theta ,\mu )\in \mathrm{\Omega }$. The corresponding minimizing path of the minimizer can be extended to a non-homographic periodic solution if θ is commensurable with π or a quasi-periodic solution if θ is not commensurable with π. In the variational method with the SPBC, we only impose constraints on the boundary and we do not impose any symmetry constraint on solutions. Instead, we prove that our solutions that are extended from the initial minimizing paths possess certain symmetries.The periodic solutions can be further classified as simple choreographic solutions, double choreographic solutions and non-choreographic solutions. Among the many stable simple choreographic orbits, the most extraordinary one is the stable star pentagon choreographic solution when $(\theta ,\mu )=(\frac{4\pi }{5},1)$. Remarkably the unequal-mass variants of the stable star pentagon are just as stable as the equal mass choreographies.