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ObjectiveAssessment of vessel walls is an integral part in diagnosis and disease monitoring of vascular diseases such as vasculitis. Vessel wall imaging (VWI), in particular of intracranial arteries, is the domain of Magnetic Resonance Imaging (MRI) – but still remains a challenge. The tortuous anatomy of intracranial arteries and the need for high resolution within clinically acceptable scan times require special technical conditions regarding the hardware and software environments.Materials and methodsIn this work a dedicated framework for intracranial VWI is presented offering an optimized, black-blood 3D T1-weighted post-contrast Compressed Sensing (CS)-accelerated MRI sequence prototype combined with dedicated 3D-GUI supported post-processing tool for the CPR visualization of tortuous arbitrary vessel structures.ResultsUsing CS accelerated MRI sequence, the scanning time for high-resolution 3D black-blood CS-space data could be reduced to under 10 min. These data are adequate for a further processing to extract straightened visualizations (curved planar reformats – CPR). First patient data sets could be acquired in clinical environment.ConclusionA highly versatile framework for VWI visualization was demonstrated utilizing a post-processing tool to extract CPR reformats from high-resolution 3D black-blood CS-SPACE data, enabling simplified and optimized assessment of intracranial arteries in intracranial vascular disorders, especially in suspected intracranial vasculitis, by stretching their tortuous course. The processing time from about 15–20 min per patient (data acquisition and further processing) allows the integration into clinical routine.  相似文献   
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This paper investigates the periodic switching point controllability and stabilization of periodic switched Boolean control networks (PSBCNs), and applies the obtained results to the stabilization of deterministic asynchronous Boolean control networks (DABCNs). Firstly, using the algebraic state space representation of PSBCNs, a kind of periodic switching point controllability matrix is constructed, based on which, a necessary and sufficient condition is presented for the periodic switching point reachability and controllability of PSBCNs. Secondly, using the reachable set of PSBCNs, a constructive procedure is proposed to design time-variant state feedback controllers for the periodic switching point stabilization of PSBCNs. Finally, by converting the dynamics of DABCNs into the form of PSBCNs, the time-variant state feedback stabilization problem of DABCNs is solved.  相似文献   
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The low Mach number limit of inviscid Hookean elastodynamic equations is rigorously proved in bounded domain, whole space and periodic domain, respectively. The uniform existence of smooth solutions and convergence results as the Mach number tends to zero are obtained in three different domains.  相似文献   
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建立了一个登革热在蚊子和人之间传播的模型,引入了Wolbachia、自我保护和杀虫剂三种控制措施,分别从常数控制和时变控制两个方面进行探讨。首先,分析了常数控制对模型基本再生数的影响,研究发现:Wolbachia有助于减小基本再生数,且基本再生数与自我保护和杀虫剂呈负相关。其次,以使得感染数最少且实施成本最低为目标,使用Pontryagin极值原理讨论最优控制。最后,通过数值模拟展示了最优控制的效果。  相似文献   
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ObjectivePrimary repair of peripheral nerves is recommended following transection; however, patient management following repair is challenged by a lack of biomarkers to nerve regeneration. Previous studies have demonstrated that diffusion magnetic resonance imaging (MRI) may provide viable biomarkers of nerve regeneration in injury models; though, these methods have not been systematically evaluated in graded partial transections and repairs.MethodsEx vivo diffusion MRI was performed in fixed rat sciatic nerve samples 4 or 12 weeks following partial nerve transection and repair (25% cut = 12, 50% cut = 12 and 75% cut = 11), crush injuries (n = 12), and sham surgeries (n = 9). Behavioral testing and histologic evaluation were performed in the same animals and nerve samples for comparison.ResultsDiffusion tractography provided visual characterizations of nerve damage and recovery consistent with the expected degree of injury within each cohort. In addition, quantitative indices from diffusion MRI correlated with both histological and behavioral evaluations, the latter of indicated full recovery for sham and crush nerves and limited recovery in all partially transected/repaired nerves. Nerve recovery between 4 and 12 weeks was statistically significant in partial transections 50% and 75% depth cuts (p = 0.043 and p = 0.022) but not for 25% transections.InterpretationOur findings suggest that DTI can i) distinguish different degrees of partial nerve transection following surgical repair and ii) map spatially heterogeneous nerve recovery (e.g., due to collateral sprouting) from 4 to 12 weeks in partially transected nerves.  相似文献   
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Nonlinear Dynamics - The aeroelastic behavior of a planar prismatic visco-elastic structure, subject to a turbulent wind, flowing orthogonally to its plane, is studied in the nonlinear field. The...  相似文献   
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A model for the mechanics of woven fabrics is developed in the framework of two-dimensional elastic surface theory. Thickness effects are modeled indirectly in terms of appropriate constitutive equations. The model accounts for the strain of the fabric and additional effects associated with the normal bending, geodesic bending, and twisting of the constituent fibers.  相似文献   
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