Optimal adaptive generalized Pólya urn design for multi-arm clinical trials

A class of optimal adaptive multi-arm clinical trial designs is proposed based on an extended generalized Pólya urn (GPU) model. The design is applicable to both the qualitative and quantitative responses and achieves, asymptotically, some pre-specified optimality criterion. Such criterion is specified by a functional of the response distributions and is implemented through the relationship between the design matrix and its first eigenvector. The asymptotic properties of the design are studied using the existing methods on GPU. Some examples for commonly used clinical designs are given as illustration.     

Some properties of projectors associated with the WLSE under a general linear model

Projectors associated with a particular estimator in a general linear model play an important role in characterizing statistical properties of the estimator. A variety of new properties were derived on projectors associated with the weighted least-squares estimator (WLSE). These properties include maximal and minimal possible ranks, rank invariance, uniqueness, idempotency, and other equalities involving the projectors. Applications of these properties were also suggested. Proofs of the main theorems demonstrate how to use the matrix rank method for deriving various equalities involving the projectors under the general linear model.     

A cubically convergent Newton-type method under weak conditions

Under weak conditions, we present an iteration formula to improve Newton's method for solving nonlinear equations. The method is free from second derivatives, permitting f^′(x)=0 in some points and per iteration it requires two evaluations of the given function and one evaluation of its derivative. Analysis of convergence demonstrates that the new method is cubically convergent. Some numerical examples illustrate that the algorithm is more efficient and performs better than classical Newton's method.     

Limit cycles of polynomial differential systems with homogeneous nonlinearities of degree 4 via the averaging method

By using the averaging method, we study the limit cycles for a class of quartic polynomial differential systems as well as their global shape in the plane. More specifically, we analyze the global shape of limit cycles bifurcating from a Hopf bifurcation and also from periodic orbits with linear center , . The perturbation of these systems is made inside the class of quartic polynomial differential systems without quadratic and cubic terms.     

An explicit solution of the large deformation of a cantilever beam under point load at the free tip

The large deformation of a cantilever beam under point load at the free tip is investigated by an analytic method, namely the homotopy analysis method (HAM). The explicit analytic formulas for the rotation angle at the free tip are given, which provide a convenient and straightforward approach to calculate the vertical and horizontal displacements of a cantilever beam with large deformation. These explicit formulas are valid for most practical problems, thus providing a useful reference for engineering applications. The corresponding Mathematica code is given in the Appendix.     

Multi-parameter regularization and its numerical realization

In this paper we propose and analyse a choice of parameters in the multi-parameter regularization of Tikhonov type. A modified discrepancy principle is presented within the multi-parameter regularization framework. An order optimal error bound is obtained under the standard smoothness assumptions. We also propose a numerical realization of the multi-parameter discrepancy principle based on the model function approximation. Numerical experiments on a series of test problems support theoretical results. Finally we show how the proposed approach can be successfully implemented in Laplacian Regularized Least Squares for learning from labeled and unlabeled examples.     

The skim of balance theory of 3D garment simulation

The balance theory of 3D garment simulation tries to integrally study the complex system of human body-fabric-environment. The theory includes the geometrical balance, dynamic balance, pressure balance, and heat and moisture transfer balance. In this paper, the ICAD-balance equations are established based on the framework of balance theory and the heat and moisture transfer model of garment. A finite volume method is employed to solve the equations. Experiment results show that ICAD-balance equations can excellently simulate real situation. Therefore, our balance theory provides a good tool for customized clothing design, electronic mirror for clothing-test-platform, and comfortable clothing evaluation research.     

On a rational differential quadrature method in irregular domains for problems with boundary layers

A rational differential quadrature method in irregular domains (RDQMID) is investigated to deal with a kind of singularly perturbed problems with boundary layers. Through a transformation, the boundary layer, which may be not straight, is transformed into a segment of a line parallel to one of the Cartesian axes. The rational differential quadrature method (RDQM) is applied to discretize the governing equation. Finally, a direct expansion method of the boundary conditions (DEMBC) is raised to deal with the boundary conditions. Numerical experiments show that RDQMID is of high accuracy, efficiency and easy to programme.     

On the block GMRES method with deflated restarting

In this paper, we consider the block-GMRES method with deflated restarting for solving nonsymmetric linear systems with multiple right-hand sides. We modify slightly the restarted block-GMRES method with deflation of eigenvalues proposed by Morgan to obtain a new one. It is shown that the modified method is mathematically equivalent to the Morgan’s original method. However, the error analysis shows the modified version minimizes the numerical errors during a restart and therefore is better suited if the linear systems have to be solved with high precision. Numerical experiments report the effectiveness of the modified method.