Design and Synthesis of 1-Benzyl-3-(a-hydroxy-(un)substituted benzylidene)pyrrolidine-2,4-diones as Potential Herbicides

The inhibitors of 4-hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) are an new kind of herbicides.[1]Generally, in structure, potent herbicides of this kind must possess: (1) a tricarbonyl methane structure and one of the three carbonyl groups must be a subustituted benzoyl group; (2) the compound must be able to enolise so that the enolate is capable of inhibiting HPPD enzyme by competitive combination with Fe2+, the reaction center of HPPD enzyme.[2]Recently, we noticed that the 3-acyltetramic acids form an expanding group of antibiotics and pigments from micro-organisms,[3] they display a range of biological activities[4] and all of this kind compounds possess all of the characters mentioned above. Tests of their antimicrobial activities indicated that the structure of the acyl substituent at the 3-position was important to many typical antibiotics.[4～6] These characters stimulated us to study this kind of compounds so as to discover new herbicides. In this report, we synthesized a series of compounds 3 and tested their herbicidal activities to investigate their structure-activity relationships.     

THE STRUCTURAL BASIS OF THE POOR FIBRIN SPECIFICITY OF UROKINASE(Ⅰ)——KNOWLEDGE-BASED PREDICTION OF KRINGLE STRUCTURES OF UROKINASE AND ITS RELATED PROTEINS

The Kringle-1 structure of plasminogen (PGK-1), the Kringle-2 structure of tissue plasminogen activator (PAK-2) and the Kringle structure of prourokinase (UKK) has been modeled on the basis of the three-dimensional structure of Kringle-1 of prothrombin (PTK-1) at 2.8 resolution. The predicted three-dimensional structure of these Kringles shows that the binding site of PGK-1 is characterized by an apparent dipolar site, the polar parts of which are separated by a hydrophobic region. PAK-2 possesses the anionic center but has not a cationic binding center which might be provided by a guanidinium group from Arg-69 located adjacent to the Arg-71 position. UKK possesses neither the anionic binding center nor the cationic center which are probably the main reason for the poor fibrin specificity of urokinase.     

Synthesis, Structure and Conductivity of the New Charge-transfer Salt (ET)_2(CH_2=CH-CH_2-SO_3)·H_2O

ET is one of the most famous electron-donor molecules, which forms charge-transfer complexes (abbr. CT-complexes) with various types of counterions. These complexes have received intense attention because a wide range of physical properties such as conductivity and superconductivity1, ferromagnetism2-4 and nonlinear optical properties5 was found in these materials. Although the majority of the ET-based CT-complexes were prepared by combining with inorganic counterions, CT-complexes with o…     

螺旋轴流式多相泵流动参数设计值探讨

本文在对螺旋轴流式多相泵高速试验的基础上,通过三级多相泵输送性能情况来分析动态参数进口冲角、相对液流角和比转速在设计时对增压单元参数的影响,从而改进增压单元的设计,使多相泵能具有更好的输送性能。     

超声波提取-氢化物发生-原子荧光光谱法测定稻米中的硒

建立了超声波提取-氢化物发生-原子荧光光谱法测定稻米硒含量的分析方法,对仪器条件和反应条件进行了选择、优化.样品加硝酸-高氯酸(3+2)混酸,超声波提取20min,热消解.在铁氰化钾-盐酸体系中,采用校准曲线法定量分析.结果表明,大米标准物质中硒的测定值与标准值相吻合.该法线性范围为0-20μg/L,检出限为0.2μg/L,回收率为92.4％-103.9％,相对标准偏差为3.1％-5.8％.方法准确、灵敏、简便、快速,是测定稻米中硒含量的理想方法.     

荧光光谱法辨别丙二醇和二甘醇

以齐药二厂的假药事件为背景,对1,2-丙二醇、1,3-丙二醇和二甘醇的吸收光谱和荧光光谱进行了测量,实验结果证明光谱法不失为一种快捷有效的区分手段.在紫外吸收光谱中,可以通过最大吸光度的差异区分二甘醇和丙二醇;在一定紫外波长激励下,三种醇的荧光光谱特性均存在差异,以此可以对三种醇作出有效区分;在230nm激发下,将二甘醇和两种丙二醇分别混合,混合溶液的相对荧光强度均与两种丙二醇体积比呈线性反比关系,这在一定程度上证明了二甘醇的荧光量子效率大于两种丙二醇.     

Numerical Simulation on the Production Mechanism of Surface-Wave Plasmas Sustained along a Metal Rod

For interpreting the production mechanism of surface-wave plasmas sustained along a metal rod, electromagnetic simulation on the electromagnetic field distributions and particle-in-cell/Monte Carlo collision （PIC/MCC） simulation of the ionization process are present. The results show that the enhanced electric field of surface plasmon polaritons （SPPs） can be excited in the ion sheath layer between the negative-voltage metal rod and the surface-wave plasmas, which is responsible for maintaining the plasma discharge. Moreover, the spatio-temporal evolutions of plasma density and electric fields are simulated by the PIC/MCC model. It is further suggested that the expanded ion sheath layer can extend the length of plasma domain by increasing the plasma absorbed energy from SPPs.     

具有特大磁电阻效应钙钛矿材料的制备及性能分析

通过固相烧结法制备了具有特大磁电阻效应的钙钛矿材料Pr0.64Ag0.044MnAl0.2O3.利用结构和成分分析,发现此材料只有在1 100℃高温烧结下才能生成完整的钙钛矿结构,且属于立方晶系,晶格常量a≈0.386 nm.在0.4 T的外磁场下,磁电阻值在122 K处达到最大,约为19.2%,为巨磁电阻实验提供了较好的样品.     

矿石中金的分析不确定度评定

针对原子吸收光谱法测定金矿石中金的实验过程,详细地分析了引入的不确定度来源。测定结果的不确定度由标准配制、样品制备、曲线拟合、样品均匀性及检验重复性4个部分引入的不确定度分量组成,样品制备过程中考虑了活性炭吸附率的影响,求得测量结果的标准不确定度和扩展不确定度分别为0.043μg/g和0.09μg/g。