Nanoparticle carriers based on copolymers of poly(ε-caprolactone) and hyperbranched polymers for drug delivery

Novel amphiphilic copolymers based on poly(ε-caprolactone) (PCL) and hyperbranched poly (amine-ester) (HPAE) with various compositions were synthesized. The amphiphilic copolymers can self-assemble into nanoscopic micelles and their hydrophobic cores can encapsulate doxorubicin (DOX) in aqueous solutions. The DOX-loaded HPAE-co-PCL nanoparticles diameter increased from 121 to 184 nm with the increasing PCL segment in the copolymer composition. An in vitro study at 37°C demonstrated that DOX-release from nanoparticles at pH 5.0 was much faster than that at pH 7.4. The cytotoxicity for HeLa cells study demonstrated that DOX-loaded HPAE-co-PCL nanoparticles exhibited the anti-tumor effect was enhanced significantly, suggesting that the DOX-loaded HPAE-co-PCL nanoparticles have great potential as a tumor drug carrier.     

逆极限空间上的ε-紊动

设ｆ是紧致度量空间上的满映射，σ_ｆ为ｆ的逆极限空间上的移位映射．本文证明，存在ε，ε′＞０，ｆ是ε-紊动的当且仅当σ_ｆ是ε′-紊动的．此外，本文还讨论了ｆ是非满映射和线段自映射的情形．     

Preparation of thermoresponsive and pH-sensitivity polymer magnetic hydrogel nanospheres as anticancer drug carriers

In this work, a novel thermo and pH responsive magnetic hydrogel nanosphere poly(N-isopropylacrylamide-co-acrylic acid)/Fe(3)O(4) (poly(NIPAAm-co-AA)/Fe(3)O(4)) has been successfully prepared. The magnetic hydrogel nanospheres with thermo and pH-sensitivity were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier transform infrared-spectrometer (FT-IR), UV-vis absorption spectroscopy, and vibrating sample magnetometer (VSM). The magnetic hydrogel nanospheres exhibited uniform sphere structures and superparamagnetic property. Finally, the drug loading capacities and the releasing behavior of the magnetic hydrogel nanospheres were investigated with doxorubicin hydrochloride (DOX) as an anticancer drug model. The resulting magnetic hydrogel nanospheres exhibited high encapsulation efficiency (95%) to DOX under an appropriate condition. In vitro release experiments revealed that release was faster at pH 5.3 (37°C) than at pH 7.4 (25°C) or pH 7.4 (37°C). The DOX-loaded magnetic hydrogel nanospheres also showed enhanced anticancer effect compared with the free drug in vitro. These presented results suggested that the magnetic hydrogel nanospheres have a potential as tumor targeting drug carrier.     

双面抛光工艺的流场压力分布

建立了双面抛光工艺中晶片上下表面的压力分布模型,获得了晶片和抛光垫表面的速度分布关系,分析了自由晶片在抛光过程中的运动状态以及在压力荷载及转矩平衡时晶片上下表面的平均压力分布.数值计算结果表明:荷载压力越大,平均压差率越小;抛光垫转速越小,太阳轮转速越小;抛光液粘度越小,平均压差率越小.同时,根据通过调整抛光参数组合获得了最小的平均压差率,并利用正交实验法数值分析.研究发现抛光工艺参数对压力分布影响的主次关系依次为荷载压力、抛光液粘度、抛光垫转速、太阳轮转速.