Targeting the cytochrome bc1 complex for drug development in M. tuberculosis: review

Molecular Diversity - The terminal oxidases of the oxidative phosphorylation pathway play a significant role in the survival and growth of M. tuberculosis, targeting these components lead to...     

Isometric multipliers of a vector valued Beurling algebra on a discrete semigroup

Let (S,ω) be a weighted abelian semigroup, let M _ω (S) be the semigroup of ω-bounded multipliers of S, and let \(\mathcal {A}\) be a strictly convex commutative Banach algebra with identity. It is shown that T is an onto isometric multiplier of \(\ell ^{1}(S,\omega , \mathcal {A})\) if and only if there exists an invertible σ ∈ M _ω (S), a unitary point \(a \in \mathcal {A}\), and a k>0 such that \(T(f)= ka{\sum }_{x \in S} f(x)\delta _{\sigma (x)}\) for each \(f={\sum }_{x \in S}f(x)\delta _{x} \in \ell ^{1}(S,\omega ,\mathcal {A})\). It is also shown that an isomorphism from \(\ell ^{1}(S_{1},\omega _{1},\mathcal {A})\) onto \(\ell ^{1}(S_{2},\omega _{2}, \mathcal {B})\) induces an isomorphism from \(M(\ell ^{1}(S_{1},\omega _{1},\mathcal {A}))\), the set of all multipliers of \(\ell ^{1}(S_{1},\omega _{1},\mathcal {A})\), onto \(M(\ell ^{1}(S_{2},\omega _{2},\mathcal {B}))\).     

Approximation of quadrilaterals by rational quadrilaterals in the plane

Many questions about triangles and quadrilaterals with rational sides, diagonals and areas can be reduced to solving certain diophantine equations. We look at a number of such questions including the question of approximating arbitrary triangles and quadrilaterals by those with rational sides, diagonals and areas. We transform these problems into questions on the existence of infinitely many rational solutions on a two parameter family of quartic curves. This is further transformed to a two parameter family of elliptic curves to deduce our main result concerning density of points on a line which are at a rational distance from three collinear points (Theorem 4). We deduce from this a new proof of density of rational quadrilaterals in the space of all quadrilaterals (Theorem 39). The other main result (Theorem 3) of this article is on the density of rational triangles which is related to analyzing rational points on the unit circle. Interestingly, this enables us to deduce that parallelograms with rational sides and area are dense in the class of all parallelograms. We also give a criterion for density of certain sets in topological spaces using local product structure and prove the density Theorem 6 in the appendix section. An application of this proves the density of rational points as stated in Theorem 31.     

Numerical Investigation of Graphene as a Back Surface Field Layer on the Performance of Cadmium Telluride Solar Cell

This paper numerically explores the possibility of ultrathin layering and high efficiency of graphene as a back surface field (BSF) based on a CdTe solar cell by Personal computer one-dimensional (PC1D) simulation. CdTe solar cells have been characterized and studied by varying the carrier lifetime, doping concentration, thickness, and bandgap of the graphene layer. With simulation results, the highest short-circuit current (I_sc = 2.09 A), power conversion efficiency (η = 15%), and quantum efficiency (QE~85%) were achieved at a carrier lifetime of 1 × 10³ μs and a doping concentration of 1 × 10¹⁷ cm⁻³ of graphene as a BSF layer-based CdTe solar cell. The thickness of the graphene BSF layer (1 μm) was proven the ultrathin, optimal, and obtainable for the fabrication of high-performance CdTe solar cells, confirming the suitability of graphene material as a BSF. This simulation confirmed that a CdTe solar cell with the proposed graphene as the BSF layer might be highly efficient with optimized parameters for fabrication.     

Higher-Order $(F,\alpha, \beta, \rho, d, E) $-Convexity in Fractional Programming

In this paper we define higher order $(F,\alpha, \beta, \rho,d, E)$-convex function with respect to $E$-differentiable function $K$ and obtain optimality conditions for nonlinear programming problem (NP) from the concept of higher order $(F,\alpha, \beta, \rho,d)$-convexity. Here, we establish Mond-Weir and Wolfe duality for (NP) and utilize these duality in nonlinear fractional programming problem.     

The development of platinum-rhodium alloy coatings on SS304 using a pulse/direct electrodeposition technique and their application to antibacterial activity

The current research focused on the development of Platinum–Rhodium alloy coating (Pt– Rh) on SS304 and its applications in antibacterial studies. Electrodeposition is considered to be one of the most suitable methods because it enhances the therapeutic effects of noble metals (Pt–Rh alloy). The electrodeposited coating is an economical and time-saving alternative to existing coating methods. The newly developed Pt–Rh coating was investigated using a scanning electron microscope (SEM) and an atomic force microscope (AFM). Using the agar Petri plate and broth culture method, the antibacterial effect of the platinum-rhodium alloy was investigated against Gram-negative Escherichia coli and Gram-positive bacteria such as Staphylococcus saprophytes, Bacillus Subtilis, and Enterococcus faecalis. The Pt–Rh alloy coated samples obtained by Direct current (DC) and Pulse coating (PC 50% and PC 75%) were examined for antibacterial study. The PC 75% Pt–Rh alloy coating exhibits significant antibacterial activity, demonstrating a maximum zone of inhibition while leaving the rest of the coated samples by DC and PC 50% duty cycles. The study also found that when the concentration of Pt–Rh solution rises from 5 μL to 15 μL, so does the antibacterial activity. The findings of the study showed that electrodeposited platinum-rhodium alloy metal ions may be handy bacteriostatic in the coming years.     

Synthesis of phenanthro[a] phenazine derivatives: a novel ring structure forming discotic liquid crystals

Phenanthro[a] phenazine, a new heterocyclic ring structure of both biological and physical interest, has been prepared by coupling 1,2-phenylenediamine with triphenylene-1,2-diquinone derivatives in high yields. 2,3,6,7,10-Penta-alkoxyphenanthro[a] phenazines are mesogenic over a broad temperature range. These novel unsymmetrical, coloured, polar, heteroaromatic discotic mesogens are potential candidates for the study of conducting, photoconducting, electroluminescence, photorefrective, etc. properties.     

Rheological characteristics of CeO2, Al2O3 and their hybrid mixture in ethylene glycol base fluid in the wide range of temperature and concentration

Journal of Thermal Analysis and Calorimetry - In the present work, the rheological behaviour of three different categories of nanofluid samples, 25 nm CeO2/EG, 13 nm Al2O3/EG and...     

Spectroscopic and chemical reactivity analysis of D-Myo-Inositol using quantum chemical approach and its experimental verification

Glow discharge conditioning (GDC) has long been accepted as one of the basic wall conditioning techniques for achieving ultrahigh vacuum in an unbaked chamber. As a part of this fundamental experimental study, a test chamber has been fabricated from stainless steel 304 L with its inner surface electropolished on which a detailed investigation has been carried out. Both helium and hydrogen gases have been employed as discharge cleaning medium. The discharge cleaning was carried out at 0.1 A /m ² current density with working pressure maintained at 1.0 × 10 ^-2 mbar. It was experimentally observed that the pump-down time to attain the base pressure ~10 ^-8 mbar was reduced by 62% compared to the unbaked chamber being pumped to this ultimate vacuum. The results were similar irrespective of whether the discharge cleaning medium is either hydrogen or helium. It was also experimentally established that a better ultimate vacuum could be achieved as compared to theoretically calculated ultimate vacuum with the help of discharge cleaning.