急性髓细胞白血病基因筛选模型的贝叶斯分析

基因表达数据蕴含着大量的生物信息,在生物基因信息研究中,筛选表达水平发生显著变化的差异基因是认识疾病形成机理和辅助靶点药物研究的关键问题.根据急性髓细胞白血病(AML)的基因表达数据,构造基因均值差序列,建立贝叶斯分层混合模型,并为模型的参数赋予具有基因生物特征的先验信息.采用马尔可夫链蒙特卡洛(MCMC)算法对模型参数进行估计,并筛选出急性髓细胞白血病差异表达基因.在实际数据分析中,从美国生物信息中心(NCBI)的高通量基因表达数据库中获取急性髓细胞白血病基因数据集,从经过非特异滤波预处理的14688个急性髓细胞白血病基因中筛选出711个差异表达基因,差异表达基因数仅占急性髓细胞白血病基因总数的4.84%,这一结果与基因差异表达的生物学原理相吻合.     

配位体修饰氟化锶纳米分层微球的可控合成

以硝酸锶为锶源,氟化钠为氟源,乙二胺四乙酸二钠(EDTANa2)为配位体,经微波促进合成了配位体修饰氟化锶纳米分层微球(1),其结构和形貌经XRD和SEM表征。物料比r[n(EDTANa2)∶n(Sr2+)]和反应温度(t)对1rt形貌影响较大。结果表明,在最佳反应条件[n(Sr2+)5 mmol,r=7,于120℃/600 W反应]下合成的17120分层清晰,分散性好,球体均匀,直径600 nm~800 nm。     

Non-axisymmetrical vibration of elastic circular plate on layered transversely isotropic saturated ground

The non-axisymmetrical vibration of elastic circular plate resting on a layered transversely isotropic saturated ground was studied.First,the 3-d dynamic equations in cylindrical coordinate for transversely isotropic saturated soils were transformed into a group of governing differential equations with 1-order by the technique of Fourier ex- panding with respect to azimuth,and the state equation is established by Hankel integral transform method,furthermore the transfer matrixes within layered media are derived based on the solutions of the state equation.Secondly,by the transfer matrixes,the general solutions of dynamic response for layered transversely isotropic saturated ground excited by an arbitrary harmonic force were established under the boundary conditions, drainage conditions on the surface of.ground as well as the contact conditions.Thirdly, the problem was led to a pair of dual integral equations describing the mixed boundary- value problem which can be reduced to the Fredholm integral equations of the second kind solved by numerical procedure easily.At the end of this paper,a numerical result concerning vertical and radical displacements both the surface of saturated ground and plate is evaluated.     

调谐流体阻尼器（TLD）及其应用

以两层流体调谐阻尼器为例，介绍了ＴＬＤ的自振特性和减振机理，通过计算实例阐明了两层流体ＴＬＤ的优点和应用前景     

复合材料结构的内部分层及其扩展

本文用接触观点分析了复合材料壳体结构的内部分层问题，建立了求解摩擦接触问题的有限元迭代格式，并采用释放率判据分析分层裂纹的扩展。分层裂纹前缘采用轴对称奇异单元，并了结构的大变形特性。计算表明，层间裂纹呈Ⅱ型扩展趋势。本文同时还分析了层间摩擦系数的影响，并指出分层将导致壳体结构承载能力显著下降。     

Analysis of energy release rate for composite delaminated cylindrical shells subjected to axial compression

In this paper, the postbuckling governing equations and the analytical expression of the energy release rates associated with delamination growth in a compression-loaded cylindrical shell are derived by using the variational principle of moving boundary and the Griffith fracture criterion. The finite difference method is used to generate the postbuckling solutions of the delaminated cylindrical shells, and with these solutions, the values of the energy release rates are determined. In simulational examples, the effects of a wide range of parameters, such as delamination sizes and depths, boundary conditions, geometrical parameters, material properties and laminate stacking sequences on the energy release rates of axisymmetrical laminated cylindrical shells are intensively discussed.The English text was polished by Yunming Chen.     

有流存在下三层密度分层流体毛细重力波二阶Stokes波解

以小振幅波理论为基础,利用摄动方法研究了有背景流场存在时三层密度分层流体的毛细重力波,给出了三层成层状态下各层流体速度势的二阶渐近解及毛细重力波面位移的二阶Stokes波解.结果表明:一阶解及二阶解除了依赖于各层流体的厚度及密度,也依赖于表面张力和各层流体的背景流场.     

我国公民权利意识的抽样调查方案设计

为全面、准确地了解我国公民的权利意识现状,本文将调查总体划分为两个子总体:大学生子总体和居民家庭子总体,设计了一套分层多阶段系统pps调查方案,给出确定各阶段样本量的原则和方法,讨论了调查中出现无回答问题的补救措施,给出了主要估计量及其精度的估计,针对调查中复杂样本的方差估计,本文提出使用刀切法进行估计。     

含层间短裂纹层合板的解析－分区变分解法

将层板横截面分为含裂纹区与不含裂纹区，在每一区内，根据夏变函数理论与特征函数展开法，得到了各自区内满足所有支配方程、裂纹表面边界条件与层间连续条件的位移与应力的特征展开式，然后利用分区广义变分原理满足裂纹表面边界以外的边界条件以及两区之间的交界条件，并由此求得奇异场控制量（广义应力强度因子）。