Pattern transition and regulation in a subthalamopallidal network under electromagnetic effect

Although the significant roles of magnetic induction and electromagnetic radiation in the neural system have been widely studied, their influence on Parkinson's disease (PD) has yet to be well explored. By virtue of the magnetic flux variable, this paper studies the transition of firing patterns induced by magnetic induction and the regulation effect of external magnetic radiation on the firing activities of the subthalamopallidal network in basal ganglia. We find: (i) The network reproduces five typical waveforms corresponding to the severity of symptoms: weak cluster, episodic, continuous cluster, episodic, and continuous wave. (ii) Magnetic induction is a double-edged sword for the treatment of PD. Although the increase of magnetic coefficient may lead the physiological firing activity to transfer to pathological firing activity, it also can regulate the pathological intensity firing activity with excessive β-band power transferring to the physiological firing pattern with weak β-band power. (iii) External magnetic radiation could inhibit continuous tremulous firing and β-band power of subthalamic nucleus (STN), which means the severity of symptoms weakened. Especially, the bi-parameter plane of the regulation region shows that a short pulse period of magnetic radiation and a medium level of pulse percentage can well regulate pathological oscillation. This work helps to understand the firing activity of the subthalamopallidal network under electromagnetic effect. It may also provide insights into the mechanisms behind the electromagnetic therapy of PD-related firing activity.     

太阳帆塔轨道和姿态耦合动力学建模及辛求解

在建立太阳帆塔太阳能电站简化模型的基础上,将系统的动力学方程从Lagrange体系导入到了Hamilton体系,给出了带约束的Hamilton正则方程;进而采用祖冲之类算法和辛Runge-Kutta方法分析了太阳帆塔轨道和姿态耦合系统的动力学特性,并讨论了算法的保能量、保约束特性;最后,数值模拟了系统的动力学特性,说明了所提方法的有效性.     

材料弹塑性性能数值模拟的多尺度方法

将均匀化方法和渐近分析(Asymptotic Analysis)与参变量变分原理相结合提出了一种模拟复合材料非线性性能的多尺度数值方法.该方法用渐近分析建立宏-细观变量之间的联系,利用参变量变分原理计算非线性响应,求解过程采用迭代算法.为提高计算精度,针对Von-Mises准则和Tsai-Hill准则,提出了一个基于参变量变分原理的改进算法,算例表明该方法可以显著消除传统方法采用线性展开式构造线性互补条件所带来的误差.     

EXACT LINEARIZATION BASED MULTIPLE-SUBSPACE ITERATIVE RESOLUTION TO AFFINE NONLINEAR CONTROL SYSTEM

To the optimal control problem of affine nonlinear system, based on differential geometry theory, feedback precise linearization was used. Then starting from the simulative relationship between computational structural mechanics and optimal control, multiple-substructure method was inducted to solve the optimal control problem which was linearized. And finally the solution to the original nonlinear system was found. Compared with the classical linearizational method of Taylor expansion, this one diminishes the abuse of error expansion with the enlargement of used region.     

THE SOLUTION FOR THE GENERALIZED RICCATIALGEBRAIC EQUATIONS OF LINEAR EQUALITY CONSTRAINT SYSTEM

I.IntroductionTheestablishmentofanalogytheorybetweencomputationalstructuralmechanicsalldoptimalcontrolisbasedonthesubstructuralchaintheoryinstructuralmechanicsandthelillearquadratic(LQ)controlprobleminoptimalcontrolllJ.Whendealillgwiththecontrolproblenlbyapplyingtheabovethe.ry,wecanrealizetheadvantagesofmethodsinstrLlcturalInechanicsl2'3].Howevermostworkhasbeenlimitedtothenon-constraintsystemandlittleworkhasbeendonefortheconstraintsystemsofLlr.InRef.I4],basedonthegeneralizedvariationalprin…     

THE APPLICATION OF THE VARIATIONAL PRINCIPLE IN THE CONSTRAINED CONTROL SYSTEM

ＴＨＥＡＰＰＬＩＣＡＴＩＯＮＯＦＴＨＥＶＡＲＩＡＴＩＯＮＡＬＰＲＩＮＣＩＰＬＥＩＮＴＨＥＣＯＮＳＴＲＡＩＮＥＤＣＯＮＴＲＯＬＳＹＳＴＥＭＤｅｎｇＺｉ－ｃｈｅｎ（邓子辰）（ＮｏｒｔｈｗｅｓｔｅｒｎＰｏｌｙｔｅｃｈｎｉｃａｌＵｎｉｖｅｒｓｉｔｙＸｉ＇ａｎ...     

基于辛理论的载流碳纳米管能带分析

基于连续介质力学理论和辛弹性理论,将载流碳纳米管等效为铁木辛柯梁,采用哈密顿变分原理建立了载流碳纳米管的振动控制方程;引入对偶变量将振动控制方程从拉格朗日体系导入到哈密顿体系下;通过波传播方法分析了载流碳纳米管的能带结构;研究了流体密度、流速对载流碳纳米管能带结构的影响;同时计算了载流碳纳米管的散射矩阵.研究发现:管内流速以及流体密度对剪切频率和弯曲频率有着非常重要的影响.研究结果表明:载流碳纳米管的剪切频率和弯曲频率因流体的加入而减小,并随流速及流体密度的增大而减小;通过对数值结果的分析发现:载流碳纳米管由于管内流体、流速以及流体密度的作用,会使得载流碳纳米管变的更"软".其中,哈密顿体系下所得出的载流碳纳米管弯曲频率随管内流体密度的增加而变小,有别于在拉格朗日体系下非局部梁理论所得的结论.同时,数值结果表明散射矩阵是酉矩阵,辛体系下的入射波功率流与反射波功率流相等,即功率流守恒,体现了辛弹性力学理论的优越性.     

多工况下结构鲁棒性拓扑优化设计

针对工程中存在多个随机不确定工况载荷作用的情况, 将鲁棒性设计思想引入到连续体结构 拓扑优化设计, 发展和完善不确定性优化理论和计算方法. 基于概率模型和SIMP方法, 提出以结构柔顺度标准差最小化为目标、具有体积约束的连续体鲁棒性拓扑优化数学模型. 通过对目标函数及其灵敏度计算公式的推导, 采用数学规划法实现优化问题的求解. 数值算 例验证了所提优化模型的正确性及算法的有效性, 并通过与确定性优化结果的比较, 证明鲁棒性拓扑优化能够给出结构柔顺性变异更小的材料分布.     

多层简化应变梯度Timoshenko梁的变分原理分析

材料特征尺寸与其内禀尺寸相当时,材料表现出明显的尺寸效应.基于简化的应变梯度理论,通过半逆法,本文给出多层简化应变梯度Timoshenko梁的变分原理,通过最小总势能原理导出系统的边界条件并对其低阶和高阶边界条件进行讨论,随后给出简支梁系统屈曲载荷和振动频率的Rayleigh(瑞利)解.通过双层梁系统的振动分析算例得到内禀尺寸、长径比等因素对梁系统振动频率的影响.该文构造的Rayleigh解有望对其他数值方法,如有限元法、传递矩阵法等,提供一定的参考和对比.     

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超轻多孔金属材料因其具有优良的结构效率和广泛的多功能应用前景，近年来已成为国内外 众多研究所关注的热点. 本文就学术界关注的多孔金属材料的宏观等效模型建模与材料微 结构的多功能优化设计进行了综述.