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1.
Giuseppe C. Pappalardo Eugenio Tondello 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1):5-10
Abstract The total energy, dipole moment and electron densities for each possible rotational conformation about the Cpy-S bonds of di-2-pyridyl disulfide were evaluated by using the semi-quantitative CNDO/2 method. The conformations in which the pyridine rings are coplanar with the valency plane of the bonded sulfur atom (cis-cis, cis-trans and trans-trans) were predicted to be the most favored ones. Results of the theoretical study, when compared to some experimental determinations such as dipole moment and variable temperature pmr spectra, provided evidence that easy interconversion between these conformations can occur. 相似文献
2.
Stanislav Kafka Antonín Klásek Veronika Rosenbreierová Vladimír Mrkvi?ka 《Tetrahedron》2008,64(19):4387-4402
Wittig olefination of 3-aminoquinoline-2,4(1H,3H)-diones 1 with ethyl (triphenylphosphoranylidene)acetate (Ph3PCHCO2Et) afforded (E)-3-amino-4-ethoxycarbonylmethylene-1,2,3,4-tetrahydro-2-quinolones (E)-2 and pyrrolo[2,3-c]quinoline-2,4(3aH,5H)-diones 3. An alternative approach for the synthesis of 3 via 3-bromoacetamidoquinoline-2,4(1H,3H)-diones 7, their corresponding triphenylphosphonium salts 8, and ylides A that undergo intramolecular Wittig reaction, was investigated. Under the applied reaction conditions, the phosphonium salts 8 and ylides A are so unstable that they partly decompose to 3-acetamidoquinoline-2,4(1H,3H)-diones 9 during the synthesis of 3. 相似文献
3.
在二元配合物巴洛沙星-Tb^3+中加入ATP,Tb^3+在其特征波长545nm处的荧光强度增强,据此建立了新的巴洛沙星Tb^3+-ATP荧光体系。在最优化实验条件下,增强的荧光强度与ATP的浓度呈良好的线性关系,线性范围为2.0×10^-6-3.0×10^-5mol/L,检出限为8.0×10^-7mol/L。详细的机理研究表明,ATP能与巴洛沙星-Tb^3+形成大的三元络合物荧光体系。新建立的荧光体系成功地应用于ATP注射液中ATP的定量检测。对不同批次ATP注射液进行加标回收试验,回收率为101%-106%,测定结果的相对标准偏差为1.1%-1.9%(n=5)。 相似文献
4.
UPLC-MS法同时测定牛奶中磺胺类、喹诺酮类、甾体激素类及四环素类兽药残留 总被引:2,自引:0,他引:2
建立并优化了同时测定牛奶中10种磺胺类、6种喹诺酮类、8种甾体激素类以及1种四环素类药物共25种兽药残留的超高效液相色谱-串联质谱检测方法。样品中目标药物经5%乙酸乙腈提取,HLB固相萃取小柱净化后,通过UPLC-MS测定,外标法定量。25种兽药在不同加标浓度下的回收率为61.6%~119.2%,组内相对标准偏差(RSD)为2.5%~13.4%,组间RSD为5.8%~14.2%,方法检出限为0.5~2.0μg/kg。 相似文献
5.
Ana R. Millanao Aracely Y. Mora Nicols A. Villagra Sergio A. Bucarey Alejandro A. Hidalgo 《Molecules (Basel, Switzerland)》2021,26(23)
Broad antibacterial spectrum, high oral bioavailability and excellent tissue penetration combined with safety and few, yet rare, unwanted effects, have made the quinolones class of antimicrobials one of the most used in inpatients and outpatients. Initially discovered during the search for improved chloroquine-derivative molecules with increased anti-malarial activity, today the quinolones, intended as antimicrobials, comprehend four generations that progressively have been extending antimicrobial spectrum and clinical use. The quinolone class of antimicrobials exerts its antimicrobial actions through inhibiting DNA gyrase and Topoisomerase IV that in turn inhibits synthesis of DNA and RNA. Good distribution through different tissues and organs to treat Gram-positive and Gram-negative bacteria have made quinolones a good choice to treat disease in both humans and animals. The extensive use of quinolones, in both human health and in the veterinary field, has induced a rise of resistance and menace with leaving the quinolones family ineffective to treat infections. This review revises the evolution of quinolones structures, biological activity, and the clinical importance of this evolving family. Next, updated information regarding the mechanism of antimicrobial activity is revised. The veterinary use of quinolones in animal productions is also considered for its environmental role in spreading resistance. Finally, considerations for the use of quinolones in human and veterinary medicine are discussed. 相似文献
6.
Lipunova G. N. Nosova E. V. Vasil"eva P. V. Charushin V. N. 《Russian Chemical Bulletin》2003,52(2):457-460
The reactions of 2-cyanomethylbenzimidazole with polyfluorobenzoyl chlorides afforded 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-oxo-3-polyfluorophenylpropionitriles. Refluxing of the latter compounds in acetonitrile in the presence of DBU or in dimethylformamide in the presence of amines gave rise to fluorine-containing derivatives of benzimidazo[1,2-a]quinolone. 相似文献
7.
Zafra-Gómez A Garballo A Ballesteros O Navalón A García-Ayuso LE 《Biomedical chromatography : BMC》2008,22(11):1186-1193
A new liquid chromatography-mass spectrometry (LC-MS) method has been developed and validated for the simultaneous determination of eight quinolone antibacterials for veterinary use in processed bovine milk samples. The quinolones studied included marbofloxacin, ciprofloxacin, danofloxacin, enrofloxacin, sarafloxacin, difloxacin, oxolinic acid and flumequine. Also, a new sample-treatment procedure was used for extraction and preconcentration of these compounds. It involved defatting by centrifugation, protein precipitation by adding a mixture of glacial acetic acid-acetonitrile and removing acetonitrile with dichloromethane; finally, the acidified aqueous layer was evaporated to dryness in a speed vac system, resuspended in the mobile phase and filtered prior to LC injection. The mobile phase was composed of a formic acid aqueous solution 0.1% (v/v) and acetonitrile, with an initial composition of water-acetonitrile 95: 5 (v/v) and using linear gradient elution. Norfloxacin was used as internal standard. The limits of quantification found (2-7 ng g(-1)) were in all cases lower than the maximum residue limits tolerated by the European Union for these compounds in milk. 相似文献
8.
Zupančič M. Cerc Korošec R. Bukovec P. 《Journal of Thermal Analysis and Calorimetry》2001,65(3):787-795
The thermal behaviour of Mg(II), Zn(II) and Co(II) compounds of ciprofloxacin was studied by thermogravimetry (TG) and differential
thermal analysis (DTA) in order to determine or to confirm some structural characteristics of substances. The complexes decompose
in two steps: dehydration and pyrolytic decomposition of the anhydrous complexes to form metal oxide or metal fluoride. The
dehydration process of one magnesium(II) compound takes place in two steps suggesting a marked difference in the bonding of
water molecules. The different bonding mode of the ciprofloxacin molecules in both magnesium compounds leads to different
residues of the thermal decompositions.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
9.
《Journal of separation science》2017,40(14):2863-2882
The quinolones are derivatives of oxoquinolines and mostly known for their antibacterial and antiviral activities. Many quinolones are chiral compounds having asymmetric centers and important due to their enantioselective biological activities. In order to study the biological activities of quinolone enantiomers, to control the manufacturing of homochiral drugs and to prepare necessary quantities of pure enantiomers for preclinical or clinical trials, respective chiral separation methods are urgently needed. In this context, the present review discusses chromatographic and electrophoretic methods for the enantioseparation of chiral quinolones and provides some useful information on their physical and pharmaceutical properties. The drawbacks of currently used techniques are revealed and ways to overcome them are outlined. Moreover, recommendations for an optimal choice of a separation protocol are given. 相似文献
10.
Vijay K. Agrawal Shahnaz Bano Keshav C. Mathur Padmakar V. Khadikar 《Journal of Chemical Sciences》2000,112(2):137-146
The paper gives a brief account of the recently introduced Szeged index (Sz). Using this index antitubercular activities of
N-2,4-difluorophenyl quinolones are subjected to quantitative structure-activity relationship analysis. The potential of Sz
related to the Wiener index (W) is critically discussed. In addition, Huckel molecular orbital energies:E
HOMO,E
LUMO andE
total were also used for comparing and modelling antitubercular activities of the quinolones. The results, based on univariate
as well as multivariate regressions, have shown that W, SZ andE
total give better results and that the correlations improve in multivariate regression analyses. 相似文献