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排序方式: 共有4839条查询结果,搜索用时 15 毫秒
1.
Xiaowei Zhang Xinpeng Diao Luya Li Yuqian Zhang Man Liao Guohua Zhang Lantong Zhang 《Journal of separation science》2022,45(14):2458-2477
Ginkgolide B is a dietary diterpene with multiple pharmacological activities. However, current research on ginkgolide B is not comprehensive. The current study analyzed the metabolic profile of ginkgolide B in vivo and in vitro using ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry. To detect and identify the different metabolites in ginkgolide B, a novel data processing method was used as an assistant tool. A total of 53 different metabolites of ginkgolide B (38 phase I metabolites and 15 phase II metabolites) were detected relative to blank samples. The biotransformation route of ginkgolide B was identified as oxidation, dehydroxylation, hydrogenation, decarbonylation, demethylation, sulfate conjugation, glucose conjugation, methylation, and acetylation. The current study demonstrated a method for rapidly detecting and identifying metabolites and provided useful information to further characterize the pharmacology and mechanism of ginkgolide B. A method for the analysis of other diterpene metabolic components in vivo and in vitro was also established. 相似文献
2.
Simone Madama Ermelinda Falletta Amir Mohammad Malvandi Kevin Arzoni Carlo Brogna Marco Varelli Matteo Bertelli Matteo Conti Martina Larini Federico Guidugli Pietro Traldi Simone Cristoni 《Journal of mass spectrometry : JMS》2022,57(8):e4876
In this work, the isolation step in the linear ion trap was performed using different “q values” conditions at a low collision-induced dissociation (CID) energy leading to the parent ion resolution improvements, reasonably due to better ion energy distribution. According to the results, we obtained a greater resolution and mass accuracy operating in both traditional electrospray and low voltage ionization near the q value = 0.778 and with a CID energy of 10%. This effect was evaluated with low-molecular-mass compounds (skatole and arginine). The proposed optimization yielded a superior instrument performance without adding technological complexity to mass spectrometry analyses. 相似文献
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Javad Mashreghi Julian Ransford Thomas Ransford 《Journal of Functional Analysis》2018,274(11):3254-3262
We show that every linear functional on the Dirichlet space that is non-zero on nowhere-vanishing functions is necessarily a multiple of a point evaluation. Continuity of the functional is not assumed. As an application, we obtain a characterization of weighted composition operators on the Dirichlet space as being exactly those linear maps that send nowhere-vanishing functions to nowhere-vanishing functions.We also investigate possible extensions to weighted Dirichlet spaces with superharmonic weights. As part of our investigation, we are led to determine which of these spaces contain functions that map the unit disk onto the whole complex plane. 相似文献
6.
Diego Maldonado 《Journal of Differential Equations》2018,264(2):624-678
We prove a Harnack inequality for nonnegative strong solutions to degenerate and singular elliptic PDEs modeled after certain convex functions and in the presence of unbounded drifts. Our main theorem extends the Harnack inequality for the linearized Monge–Ampère equation due to Caffarelli and Gutiérrez and it is related, although under different hypotheses, to a recent work by N.Q. Le.Since our results are shown to apply to the convex functions with and their tensor sums, the degenerate elliptic operators that we can consider include subelliptic Grushin and Grushin-like operators as well as a recent example by A. Montanari of a nondivergence-form subelliptic operator arising from the geometric theory of several complex variables. In the light of these applications, it follows that the Monge–Ampère quasi-metric structure can be regarded as an alternative to the usual Carnot–Carathéodory metric in the study of certain subelliptic PDEs. 相似文献
7.
Miguel A. Alejo 《Journal of Differential Equations》2018,264(2):1192-1230
We show that breather solutions of the Gardner equation, a natural generalization of the KdV and mKdV equations, are stable. Through a variational approach, we characterize Gardner breathers as minimizers of a new Lyapunov functional and we study the associated spectral problem, through (i) the analysis of the spectrum of explicit linear systems (spectral stability), and controlling degenerated directions by using low regularity conservation laws. 相似文献
8.
A double phase problem with a bounded Borel measure on the right hand side is studied. We prove an optimal pointwise gradient estimate for such a measure data problem via Riesz potentials of the measure under log-Dini continuity assumption on the modulating coefficients. As a consequence, we find an optimized regularity criterion. 相似文献
9.
We derive trace formulas for a pair of self-adjoint operators and H under the assumption that is in a Schatten class. This extends the trace formulas of [8], where V alone is assumed to be in a Schatten class. Our trace formulas apply, in particular, in the setting of differential operators and are based on Taylor-like approximations of operator functions. This significantly improves non-Taylor based trace formulas of [10]. 相似文献
10.
Sasiphimol Sawadsitang Nuttika Suwannasai Wiyada Mongkolthanaruk Peni Ahmadi 《Natural product research》2018,32(19):2260-2267
The secondary metabolites of Xylaria cf. cubensis SWUF08-86 fungus were investigated, and the chromatographic separation of the crude extracts yielded seventeen compounds. The structure elucidation by spectroscopic analysis including 1D and 2D NMR and the comparison of these data with literature, along with HREIMS spectrometry, revealed one new amino amidine derivative (1), together with five known simple cyclic dipeptide analogs, diketopiperazines (2–6) and eleven other known compounds, including one hemi-cycline (10), three aromatic derivatives (11–13), one sesquiterpene (14) and three sterols (15–17). The isolated compounds were screened for anticancer and anti-pathogenic bacterial and fungal activities. Based on this work, Xylaria cf. cubensis SWUF08-86 has proven to be a diverse secondary metabolites producer. 相似文献