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探讨数字减影血管成像(DSA)、计算机断层扫描血管成像(CTA)联合磁共振(MR)影像评估急性缺血性卒中(AIS)患者脑支循环及预后性关系。选取60例大脑中动脉M1段急性闭塞所致AIS患者为研究对象,根据DSA、CTA与MR影像对其脑侧支循环评估,比较患者基线资料、结局指标等,并分析预后性。结果发现:基于DSA、CTA与MR影像对AIS患者脑侧支循环评估结果一致性良好;3种影像模式下脑侧支循环良好组与不良组结局资料差异显著(P<0.05);多因素分析显示,FVH-ASPECTS评分、rLMC评分、ASITN/SIR分级量表均为AIS患者神经功能预后的独立影响因素。总之,DSA、CTA、MR影像对AIS患者脑侧支循环评估具有一致性,且FVH-ASPECTS评分、rLMC评分、ASITN/SIR分级量表均为AIS患者神经功能预后的独立影响因素。 相似文献
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Mengya Jiao Qun Dong Yiting Zhang Min Lin Wan Zhou Tao Liu Baohong Yuan Hui Yin 《Molecules (Basel, Switzerland)》2021,26(11)
Maca (Lepidium meyenii) has emerged as a popular functional plant food because of its medicinal properties and nutritional value. Macamides, as the exclusively active ingredients found in maca, are a unique series of non-polar, long-chain fatty acid N-benzylamides with multiple bioactivities such as antifatigue characteristics and improving reproductive health. In this study, a new kind of macamide, N-benzyl eicosapentaenamide (NB-EPA), was identified from maca. We further explore its potential neuroprotective role in hypoxic–ischemic brain injury. Our findings indicated that treatment with biosynthesized NB-EPA significantly alleviates the size of cerebral infarction and improves neurobehavioral disorders after hypoxic–ischemic brain damage in neonatal mice. NB-EPA inhibited the apoptosis of neuronal cells after ischemic challenge. NB-EPA improved neuronal cell survival and proliferation through the activation of phosphorylated AKT signaling. Of note, the protective property of NB-EPA against ischemic neuronal damage was dependent on suppression of the p53–PUMA pathway. Taken together, these findings suggest that NB-EPA may represent a new neuroprotectant for newborns with hypoxic–ischemic encephalopathy. 相似文献
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In the current research, through employing the dual ligand method, a novel coordination polymer has been produced in success via the reaction between H2glu and In(NO3)3·6H2O in the existence of the nitrogen-donor chelating 2,2′-bpy ligand in CH3CN In(III) and DMF mixed solvent, and its chemical formula is In(glu)(Hglu)(2,2′-bpy) (1, 2,2′-bpy is 2,2′-bipyridine and H2glu is glutaric acid). Its application values on the acute stroke were assessed and the corresponding mechanism was investigated simultaneously. Firstly, the levels of inflammatory response in the astrocytes were evaluated by ELISA by measuring the content of inflammatory cytokines released into cerebrospinal fluid. Additionally, the miRNA199a relative expression levels in astrocytes were measured via exploiting real time RT-PCR. Molecular docking simulation demonstrated that synthesized In ion complex exhibited excellent biological activities, multiple binding interactions were formed by the carboxyl groups on the In ion complex. 相似文献
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Maria Rubega Emanuela Formaggio Franco Molteni Eleonora Guanziroli Roberto Di Marco Claudio Baracchini Mario Ermani Nick S. Ward Stefano Masiero Alessandra Del Felice 《Entropy (Basel, Switzerland)》2021,23(5)
Stroke is the commonest cause of disability. Novel treatments require an improved understanding of the underlying mechanisms of recovery. Fractal approaches have demonstrated that a single metric can describe the complexity of seemingly random fluctuations of physiological signals. We hypothesize that fractal algorithms applied to electroencephalographic (EEG) signals may track brain impairment after stroke. Sixteen stroke survivors were studied in the hyperacute (<48 h) and in the acute phase (∼1 week after stroke), and 35 stroke survivors during the early subacute phase (from 8 days to 32 days and after ∼2 months after stroke): We compared resting-state EEG fractal changes using fractal measures (i.e., Higuchi Index, Tortuosity) with 11 healthy controls. Both Higuchi index and Tortuosity values were significantly lower after a stroke throughout the acute and early subacute stage compared to healthy subjects, reflecting a brain activity which is significantly less complex. These indices may be promising metrics to track behavioral changes in the very early stage after stroke. Our findings might contribute to the neurorehabilitation quest in identifying reliable biomarkers for a better tailoring of rehabilitation pathways. 相似文献
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Rui Zhang Leng Ni Xiao Di Baitao Ma Shuai Niu Zhihua Rong Changwei Liu 《Molecules (Basel, Switzerland)》2021,26(4)
Carotid artery stenosis (CAS) is an atherosclerotic disease characterized by a narrowing of the artery lumen and a high risk of ischemic stroke. Risk factors of atherosclerosis, including smoking, hypertension, hyperglycemia, hyperlipidemia, aging, and disrupted circadian rhythm, may potentiate atherosclerosis in the carotid artery and further reduce the arterial lumen. Ischemic stroke due to severe CAS and cerebral ischemic/reperfusion (I/R) injury after the revascularization of CAS also adversely affect clinical outcomes. Melatonin is a pluripotent agent with potent anti-inflammatory, anti-oxidative, and neuroprotective properties. Although there is a shortage of direct clinical evidence demonstrating the benefits of melatonin in CAS patients, previous studies have shown that melatonin may be beneficial for patients with CAS in terms of reducing endothelial damage, stabilizing arterial plaque, mitigating the harm from CAS-related ischemic stroke and cerebral I/R injury, and alleviating the adverse effects of the related risk factors. Additional pre-clinical and clinical are required to confirm this speculation. 相似文献
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乳腺癌是当前最常见的恶性肿瘤之一,其电子病历数据可用于挖掘隐含规律,对治疗与预后分析有重要意义。通过与乳腺科医生合作,选择合适的预测模型和可视化方法,搭建了一个基于电子病历的乳腺癌群组和治疗方案可视分析系统。首先,对具有高维属性的病人进行降维和聚类处理,形成病人群组,并采用南丁格尔图、词云和时间轴可视化方法,直观展示病人群组间特征的差异;然后,用支持向量机(support vector machine,SVM)模型预测治疗方案,用平行坐标、矩阵热力图和分类图分别展示属性相关性、训练后的特征权重和预测结果;最后,用真实案例验证了系统在群组分析、治疗方案及病人属性关联分析中的有效性,从而较好地帮助医生选择合适的治疗方案。 相似文献
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秦俊法 《广东微量元素科学》2016,(3):1-6
脑卒中是目前中国最重要的公共卫生问题,正以其高发病率、高死亡率对我国造成巨大的社会、经济困难。从脑卒中的流行病学特征、脑卒中发病的危险因素、脑卒中患者的微量元素失衡及微量元素检测的临床意义四个方面阐述了微量元素与脑卒中的关系。 相似文献
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Dr. Chi Kyung Kim Taeho Kim In‐Young Choi Min Soh Dr. Dohoung Kim Young‐Ju Kim Dr. Hyunduk Jang Hye‐Sung Yang Dr. Jun Yup Kim Dr. Hong‐Kyun Park Dr. Seung Pyo Park Sangseung Park Dr. Taekyung Yu Prof. Byung‐Woo Yoon Prof. Seung‐Hoon Lee Prof. Taeghwan Hyeon 《Angewandte Chemie (International ed. in English)》2012,51(44):11172-11172
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Da-Jeong Chang Seung-Hun Oh Nayeon Lee Chunggab Choi Iksoo Jeon Hyun Sook Kim Dong Ah Shin Seo Eun Lee Daehong Kim Jihwan Song 《Experimental & molecular medicine》2013,45(11):e53
The transplantation of neural precursor cells (NPCs) is known to be a promising approach to ameliorating behavioral deficits after stroke in a rodent model of middle cerebral artery occlusion (MCAo). Previous studies have shown that transplanted NPCs migrate toward the infarct region, survive and differentiate into mature neurons to some extent. However, the spatiotemporal dynamics of NPC migration following transplantation into stroke animals have yet to be elucidated. In this study, we investigated the fates of human embryonic stem cell (hESC)-derived NPCs (ENStem-A) for 8 weeks following transplantation into the side contralateral to the infarct region using 7.0T animal magnetic resonance imaging (MRI). T2- and T2*-weighted MRI analyses indicated that the migrating cells were clearly detectable at the infarct boundary zone by 1 week, and the intensity of the MRI signals robustly increased within 4 weeks after transplantation. Afterwards, the signals were slightly increased or unchanged. At 8 weeks, we performed Prussian blue staining and immunohistochemical staining using human-specific markers, and found that high percentages of transplanted cells migrated to the infarct boundary. Most of these cells were CXCR4-positive. We also observed that the migrating cells expressed markers for various stages of neural differentiation, including Nestin, Tuj1, NeuN, TH, DARPP-32 and SV38, indicating that the transplanted cells may partially contribute to the reconstruction of the damaged neural tissues after stroke. Interestingly, we found that the extent of gliosis (glial fibrillary acidic protein-positive cells) and apoptosis (TUNEL-positive cells) were significantly decreased in the cell-transplanted group, suggesting that hESC-NPCs have a positive role in reducing glia scar formation and cell death after stroke. No tumors formed in our study. We also performed various behavioral tests, including rotarod, stepping and modified neurological severity score tests, and found that the transplanted animals exhibited significant improvements in sensorimotor functions during the 8 weeks after transplantation. Taken together, these results strongly suggest that hESC-NPCs have the capacity to migrate to the infarct region, form neural tissues efficiently and contribute to behavioral recovery in a rodent model of ischemic stroke. 相似文献