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Ⅱ-Ⅵ型量子点制备及其在生物检测中应用研究进展 总被引:9,自引:0,他引:9
Ⅱ Ⅵ型量子点特殊而优良的可见光区荧光性质使得它们在生物识别及检测中具有潜在的应用前景 ,因而引起人们的广泛关注。本文概述了Ⅱ Ⅵ型量子点的制备及其在生物检测中应用的研究进展 相似文献
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A.Peter Snyder Waleed M. Maswadeh Jay Eversole Mel Spence 《Analytica chimica acta》2004,513(2):365-377
The detection and qualitative characterization of outdoor ambient bioaerosols have a relatively greater sense of urgency in recent times.Mass-based pyrolysis-gas chromatography-ion mobility spectrometry (Py-GC-IMS) and particle-based UV-vis fluorescence technologies were spatially situated for spore and protein bioaerosol detection in a Southeastern prairie region in Alberta, Canada. Orthogonal systems analyses versus individual detector results were investigated for the temporal characterization of bioaerosols. The systems responded to low agent analyte-containing particles per liter of air (PLA) concentrations, and were verified by reference samplers. An orthogonal technologies sensor system appears to be attractive for a high confidence detection of presence and temporal characterization of bioaerosols. 相似文献
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Zachary A. Combs Sidney T. Malak Tobias König Mahmoud A. Mahmoud Jorge L. Chávez Mostafa A. El‐Sayed Nancy Kelley‐Loughnane Vladimir V. Tsukruk 《Particle & Particle Systems Characterization》2013,30(12):1071-1078
The assembly of nanoframe dimers assisted by aptamer‐functionalized smaller spherical gold nanoparticles as prospective surface‐enhanced Raman scattering (SERS) biotraps for riboflavin, an important molecule for biological electron transfer reactions, is reported. In this approach, the aptamer‐coated gold nanoparticles designed for selective binding of riboflavin also serve as the electrostatic driver for nanoframe dimerization in dilute solutions. The gold nanoframe dimers provide unique conditions for plasmonic coupling in a hot spot with sufficient space for the binding of bulky biomolecules. The use of an aptamer allows for highly selective binding of the targeted analyte as compared with conventional organic ligands with excellent low detection limit of one micromole of riboflavin. 相似文献
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Meetani MA Shin YS Zhang S Mayer R Basile F 《Journal of mass spectrometry : JMS》2007,42(9):1186-1193
Desorption electrospray ionization (DESI) mass spectrometry (MS) was used to differentiate seven bacteria species on the basis of their measured DESI-mass spectral profile. Both gram-positive and gram-negative bacteria were tested and included Escherichia coli, Staphyloccocus aureus, Enterococcus sp., Bordetella bronchiseptica, Bacillus thuringiensis, Bacillus subtilis and Salmonella typhimurium. Distinct DESI-mass spectra, in the mass range of 50-500 u, were obtained from whole bacteria in either positive or negative ion modes in less than 2 mins analysis time. Positive ion DESI-mass spectral fingerprints were compared using principal components analysis (PCA) to investigate reproducibility for the intraday and the day-to-day measurements and the method selectivity to differentiate the bacteria studied. Detailed study of variances in the assay revealed that a large contribution to the DESI-mass spectral fingerprint variation was the growth media preparation procedure. Specifically, experiments conducted with the growth media prepared using the same batch yielded highly reproducible DESI-mass spectra, both in intraday and in day-to-day analyses (i.e. one batch of growth media used over a 3-day period versus a new batch every day over the same 3-day period). Conclusions are drawn from our findings in terms of strategies for rapid biodetection with DESI-MS. 相似文献
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时间分辨荧光生物标记作为一种灵敏的非放射性标记技术,在科研及医疗机构已获得广泛应用。传统的时间分辨荧光标记以稀土螯合物作为分子探针,存在着光化学稳定性差、长期生物毒性以及价格昂贵等缺点。稀土掺杂无机纳米晶因其优异的光化学与光物理性能,是目前普遍看好且有望成为替代稀土螯合物的新一代时间分辨纳米荧光探针。利用稀土纳米探针的长寿命发光,结合时间分辨探测技术,可以有效抑制短寿命的背景荧光干扰,显著提高生物检测的灵敏度和信噪比。本文系统地介绍了稀土掺杂无机纳米晶独特的发光性能及其作为时间分辨纳米荧光探针在疾病标志物体外检测方面的最新研究进展,并对该领域的未来发展方向和趋势进行了深入探讨。 相似文献
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