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ABSTRACT The asymmetric cross-aldol reaction of simple ketones (acetone, cyclohexanone) with isatin derivatives in the presence of crude extract from earthworms as green and effective biocatalyst proceeds easily in MeCN/H2O (1:1) as solvent to afford 3-hydroxy-2-oxindoles derivatives. Ten compounds were synthesized in high yields (62–88%) and moderate ee (29–42%). Structure of the synthesized compounds has been characterized on the basis of NMR spectra and CHN analysis. The ee of the obtained compounds was determined by chiral phase HPLC analysis. 相似文献
3.
《Discrete Mathematics》2020,343(12):112118
4.
《Arabian Journal of Chemistry》2020,13(3):4824-4834
A new partially substituted calix[4] pyrrole derivative obtained by the introduction of three thioamide functionalities in the N-rim has been synthesised and fully characterised by 1H, 13C, HSQC, ROESY NMR and mass spectroscopy. Computer modelling suggested an alternate conformation which was confirmed through ROESY 1H NMR. The receptor interacts only with the silver cation as shown by 1H NMR. The strength of interaction is quantitatively assessed by titration calorimetry. N-rim modification eliminates the possibility of interaction with anions. Unlike calix[4] pyrrole derivatives obtained by the introduction of functionalities through the meso-position, addition of Hg(NO3)2 leads to the degeneration of the receptor as demonstrated by 1H NMR, FTIR and XPS analyses. This is for the first time reported. Molecular simulation studies show significant strain in the mercury bound ligand in bonds, angles, torsions leading to the destruction of the receptor. Given the negative environmental impact produced by the availability of silver ions in aquatic organisms, the fundamental studies indicate that this receptor offers potential applications for monitoring silver (ion selective electrode) or indeed as a decontaminating material for removing silver ions from water. 相似文献
5.
《Physics letters. A》2020,384(11):126230
We utilise the pentamode metasurface to realise broadband high-efficiency and controllable asymmetric transmission. The designed metasurface can manipulate the acoustic waves, as expected from the generalised Snell's law, and exhibits unique characteristics such as extraordinary broadband acoustic control, apparent negative refraction, and conversion from the propagating wave to surface mode. The asymmetric transmission features of positive refraction for the forward incidence (FI) and negative refraction for the reverse incidence (RI) can be realised within the range of 2600 Hz to 5600 Hz by controlling the incident angle from 0° to 35° with the transmission efficiency higher than 85.4% for the FI and RI. In addition, by further adjusting the angle of incidence in the range of 25° to 90°, asymmetric transmission characteristics can be expressed as surface wave transmission for the FI and transmitted wave transmission for the RI within the same frequency ranges. 相似文献
6.
Nonlinear effects such as friction and freeplay on the control surfaces can affect aeroelastic dynamics during flight. In particular, these nonlinearities can induce limit cycle oscillations (LCO), changing the system stability, and because of this it is essential to employ computational methods to predict this type of motion during the aircraft development cycle. In this context, the present article presents a matrix notation for describing the Hénon’s method used to reduce errors when considering piecewise linear nonlinearities in the numerical integration process. In addition, a new coordinate system is used to write the aeroelastic system of equations. The proposal defines a displacement vector with generalized and physical variables to simplify the computational implementation of the Hénon’s technique. Additionally, the article discusses the influence of asymmetric freeplay and friction on the LCO of an airfoil with control surface. The results show that the extended Hénon’s technique provides more accurate LCO predictions, that friction can change the frequency and amplitude of these motions, and the asymmetry of freeplay is important to determine the LCO behavior. 相似文献
7.
《印度化学会志》2023,100(3):100935
The educational value of nanofluids in several industrial and biological sectors, particularly in fluid movement systems known as peristalsis, has piqued researchers' interest in studying the peristaltic movement of nanofluids. Additionally, nanoparticles have crucial roles in many engineering and manufacturing processes, including those involving heat exchangers, cooling systems, boilers, MEMS, chemical engineering, laser diode arrays, and cool automotive engines. Various studies have been conducted on this subject. This is done by looking at how migratory gyrotactic microorganisms migrate through an artery that is anisotropically narrowing in a blood-based nanofluid that is non-Newtonian. To comprehend, the Powell-Eyring fluid model is used how the blood's rheology differs from that of a Newtonian fluid. Both Newtonian fluid characteristics and non-Newtonian traits can be seen in this fluid pattern. Equations for continuity, temperature, motile microbes, momentum, and concentration are used to create the mathematical formulation. The series solutions, which are produced using perturbation theory solutions are discussed using graphs for all dominant parameters. Discussion also includes the distribution of temperature, velocity, and swimming microorganisms. Additionally, the effects of wall shear stress, the Nusselt and Sherwood numbers, as well as the phenomena of trapping, are all examined in detail and shown in the graphs. Entropy generation analyses have also been undertaken. The investigation also reveals a crucial behaviour in the use of the heart-lung engine for extracorporeal blood circulation in medicine that may have an impact on the damage of red blood cells as a result of the large fluctuation in wall shear stress. When liquids are transported using arthro pumps and roller pumps in living organs, the results are likewise of significant use. The results are very helpful for executing particle movements in cardiac surgery and may be applicable to the fluid peristaltic pump used in haemodialysis. 相似文献
8.
Daniel Rozsar Alistair J. M. Farley Iain McLauchlan Benjamin D. A. Shennan Ken Yamazaki Darren J. Dixon 《Angewandte Chemie (International ed. in English)》2023,62(21):e202303391
Herein we describe the enantioselective intermolecular conjugate addition of nitroalkanes to unactivated α,β-unsaturated esters, catalyzed by a bifunctional iminophosphorane (BIMP) superbase. The transformation provides the most direct access to pharmaceutically relevant enantioenriched γ-nitroesters, utilizing feedstock chemicals, with unprecedented selectivity. The methodology exhibits a broad substrate scope, including β-(fluoro)alkyl, aryl and heteroaryl substituted electrophiles, and was successfully applied on a gram scale with reduced catalyst loading, and, additionally, catalyst recovery was carried out. The formal synthesis of a range of drug molecules, and an enantioselective synthesis of (S)-rolipram were achieved. Additionally, computational studies revealed key reaction intermediates and transition state structures, and provided rationale for high enantioselectivities, in good agreement with experimental results. 相似文献
9.
Jia-Bin Pan Xuan-Ge Zhang Yi-Fan Shi Ai-Cui Han Yu-Jia Chen Jing Ouyang Mao-Lin Li Prof. Qi-Lin Zhou 《Angewandte Chemie (International ed. in English)》2023,62(15):e202300691
Free carbene readily causes multiple side reactions due to its high energy, thus its asymmetric transformation is very difficult. We present here our findings of high-pKa Brønsted acid catalysts that enable free carbene insertion into N−H bonds of amines to prepare chiral α-amino acid derivatives with high enantioselectivity. Under irradiation with visible light, diazo compounds produce high-energy free carbenes that are captured by amines to form free ylide intermediates, and then the newly designed high-pKa Brønsted acids, chiral spiro phosphamides, promote the proton transfer of ylides to afford the products. Computational and kinetic studies uncover the principle for the rational design of proton-transfer catalysts and explain how the catalysts accelerate this transformation and provide stereocontrol. 相似文献
10.
Dr. José A. Carmona Dr. Patricia Rodríguez-Salamanca Prof. Rosario Fernández Prof. José M. Lassaletta Dr. Valentín Hornillos 《Angewandte Chemie (International ed. in English)》2023,62(35):e202306981
An atroposelective Ir-catalyzed dynamic kinetic resolution (DKR) of 2-(quinolin-8-yl)benzaldehydes/1-naphthaldehydes by transfer hydrogenative coupling of allyl acetate is disclosed. The allylation reaction takes place with simultaneous installation of central and axial chirality, reaching high diastereoselectivities and excellent enantiomeric excesses when ortho-cyclometalated iridium-DM-BINAP is used as the catalyst. The racemization of the substrates occurs through a designed transient Lewis acid-base interaction between the quinoline nitrogen atom and the aldehyde carbonyl group. 相似文献