防患于未然—代谢综合症发病趋势预测模型

本文建立基于动态变异和随机转录的人类生命量化模型,对个人生物分子间相互作用和基因通路信息进行定理研究.据此筛选出代谢综合症的4个生理指标:中心肥胖指数、血压强度、血糖含量和血脂浓度.用ClinicalTrials.gov的临床数据求解模型得到,当推荐代谢综合症指数大于0.066时,患者患有代谢综合症,因此认为该指数为代谢综合症的一项数据特征.另一方面,对可能引发代谢综合症的许多并发症的21个基因通路进行了筛选,得出了PTP1B等影响最大的5个基因通路,并认为他们是代谢综合症的关键基因通路.     

Information-Disturbance Tradeoff in Estimating the Unknown Three-Qubit GHZ State

In a recent paper, Sacchi （Phys. Rev. Lett. 96 （2006） 220502） studied the information-disturbance tradeoff in estimating an unknown two-qubit maximally entangled state. In this study, we explore the tradeoff in estimating 13 an unknown three-qubit GHZ state. The optimal estimation process supplies a fidelity of 13/54 and the tradeoff interpolates smoothly between non-informative measurement and optimal estimation process.     

Methods for Derivation of Density Matrix of Arbitrary Multi-Mode Gaussian States from Its Phase Space Representation

We present a method for derivation of the density matrix of an arbitrary multi-mode continuous variable Gaussian entangled state from its phase space representation.An explicit computer algorithm is given to reconstruct the density matrix from Gaussian covariance matrix and quadrature average values.As an example,we apply our method to the derivation of three-mode symmetric continuous variable entangled state.Our method can be used to analyze the entanglement and correlation in continuous variable quantum network with multi-mode quantum entanglement states.     

Bio-macromolecular dynamic structures and functions,illustrated with DNA,antibody, and lipoprotein

Bio-macromolecules, such as proteins and nucleic acids, are the basic materials that perform fundamental activities required for life. Their structural heterogeneities and dynamic personalities are vital to understand the underlying functional mechanisms of bio-macromolecules. With the rapid development of advanced technologies such as single-molecule technologies and cryo-electron microscopy(cryo-EM), an increasing number of their structural details and mechanics properties at molecular level have significantly raised awareness of basic life processes. In this review, firstly the basic principles of single-molecule method and cryo-EM are summarized, to shine a light on the development in these fields. Secondly, recent progress driven by the above two methods are underway to explore the dynamic structures and functions of DNA, antibody,and lipoprotein. Finally, an outlook is provided for the further research on both the dynamic structures and functions of bio-macromolecules, through single-molecule method and cryo-EM combining with molecular dynamics simulations.     

物理实践课程一种新模式的实践与探索

本文从实践教学模式创新入手,提出与以往不同的基础学科实训研讨的新实践教学模式.从学生查找资料、参与讲解、讨论、设计实验和对前沿科学问题的综述等方面开展教学,使学生全程主动学习,成为学习的主导者.考核成绩也是由以上几部分构成,并且学生参与评价考核.这种实践教学模式可以在网上实现远程实践教学,此实践教学一方面通过前沿科学问题和来自实践的知识把理论与实践紧密的联系起来,另一方面通过学生全程参与促进了学生的自主学习,提高了学习兴趣,激发了学习动力.     

烧结温度对锂离子电池正极材料LiCoO2结构与电化学性能的影响

锂钴氧化物;烧结温度对锂离子电池正极材料LiCoO2结构与电化学性能的影响     

Mutation-induced spatial differences in neuraminidase structure and sensitivity to neuraminidase inhibitors

Neuraminidase(NA), a major surface glycoprotein of influenza virus with well-defined active sites, is an ideal platform for the development of antiviral drugs. However, a growing number of NA mutations have drug resistance to today's inhibitors. Numerous efforts are made to explore the resistance mechanisms through understanding the structural changes in mutated NA proteins and the associated different binding profiles of inhibitors, via x-ray, nuclear magnetic resonance,electron microscopy, and molecular dynamics methods. This review presents the architectural features of mutated NA proteins, as well as the respective inhibitor sensitivities arising from these spatial differences. Finally, we summarize the resistance mechanisms of today's neuraminidase inhibitors and the outlook for the development of novel inhibitors.     

"迟到"的结论——例谈教学的循序渐进原则

教学要讲究循序渐进的原则,即系统性、量力性以及因材施教等原则.教学是一个使学生的知识不断增加、深化的过程,是使学生能力不断提高的过程;结论、方法的获得固然重要,但过程更重要,引导学生在过程中不断拓宽加深、完善提高,培养探索、创新的能力,才是我们教学的真正目的.以下是笔者在上高三复习课时一堂课的片断.