一步法合成取代-1,2-苯醌类化合物

应用固定化多酚氧化酶催化的氧化-迈克尔加成反应,一步合成了4,5-二取代-1,2-苯醌类化合物:4,5-N,N-二(苯胺基)-1,2-苯醌,4,5-N,N-二(对甲苯胺基)-1,2-苯醌,4,5-N,N-二(间氯苯胺基)-1,2-苯醌,4,5-N,N-二(对溴苯胺基)-1,2-苯醌。用化学法(I_2—KI)进行氧化-迈克尔加成反应也成功地合成了4,5-二取代-1,2-苯醌类化合物。应用紫外光谱方法证明了氧化-迈克尔加成反应的机制。     

Synthesis of substituted 1,2-benzoquinones and substituted 3-hydroxy-4 (1H) -pyridinones: Application of oxidation-Michael addition in organic synthesis

Catechol (1) and 2-ethoxy-2-ethyl-3-hydroxy-4(1H)-pyridinone (4) derivatives can be oxidized to give ortho-quinone of 1,2-benzoquinone (2) and 2-ethoxy-2-ethyl-l,2(2H)-pyridine-3,4-dione (5) that subsequently undergo Michael addition with nucleophiles. This reaction served a convenient route to synthesize 4,5-disubstituted-l,2-benzoquinones (3a-c) and 6-substituted-3-hydroxy-4(1H)-pyridinones (6a-f) .     

Bioreduction of quinone derivatives by immobilized Baker''''s yeast in hexane

Immobilization techniques and biocatalytic transformations performed in organic media are new developing methods for organic reactions. Baker's yeast was immobilized on the alginate supports. This preparation contained about 20% of dry yeast cells. The immobilized Baker's yeast were found to be very effective in the reduction of o-benzoquinone, p-benzoquinones, naphthoquinones, and anthraquinones in hexane.     

飞片冲击起爆试验装置中炮筒材料的研究

用碳素工具钢T7代替蓝宝石制作的炮筒 ,大大降低了飞片冲击起爆试验的费用 ,对炸药的冲击起爆机理的研究提供了便利。     

一步法合成取代-1, 2-苯醌类化合物

应用固定化多酚氧化酶催化的氧化-迈克尔加成反应,一步合成了4,5-二取代-1,2-苯醌类化合物:4,5-N,N-二(苯胺基)-1,2-苯醌,4,5-N,N-二(对甲苯胺基)-1,2-苯醌,4,5-N,N-二(间氯苯胺基)-1,2-苯醌,4,5-N,N-二(对溴苯胺基)-1,2-苯醌。用化学法(I~2-KI)进行氧化-迈克尔加成反应也成功地合成了4,5-二取代-1,2-苯醌类化合物。应用紫外光谱方法证明了氧化-迈克尔加成反应的机制。