双(2-取代-3-羟基-4-吡喃酮)合铜(II)配合物的合成和降血糖作用

合成了双(2-取代-3-羟基-4-吡喃酮)合铜(II)配合物, 采用元素分析、质谱、红外光谱、电子光谱、电子自旋共振谱表征了它们为平面正方型配合物, 中心离子和配体的物质的量比为1∶2. 在STZ-糖尿病小鼠模型上, 其中双(2-乙基-3-羟基-4-吡喃酮)合铜(II)在10 mg/kg的剂量下灌胃给药, 能增加血清胰岛素的合成和分泌、降低糖尿病小鼠的血糖水平, 显示出良好的抗糖尿病的作用. 该配合物毒性低, 对正常小鼠灌胃给药的半数致死量LD₅₀是855.9 mg/kg.     

双(2-取代-3-羟基-4-吡喃酮)合铜(II)配合物的合成和降血糖作用

合成了双(2-取代-3-羟基-4-吡喃酮)合铜(II)配合物,采用元素分析、质谱、红外光谱、电子光谱、电子自旋共振谱表征了它们为平面正方型配合物,中心离子和配体的物质的量比为1∶2.在STZ-糖尿病小鼠模型上,其中双(2-乙基-3-羟基-4-吡喃酮)合铜(II)在10mg/kg的剂量下灌胃给药,能增加血清胰岛素的合成和分泌、降低糖尿病小鼠的血糖水平,显示出良好的抗糖尿病的作用.该配合物毒性低,对正常小鼠灌胃给药的半数致死量LD50是855.9mg/kg.     

顺式-二(硫氰酸根)·二氨合铂(Ⅱ)的合成、表征及其水溶液析出物质机制的探讨

Cis-diaminedithiocyanatoplatinum(Ⅱ) (cis-[Pt(SCN)₂(NH₃)₂]) was prepared and characterized through content analysis of Pt, MS, IR. The results show that the complex has cis configuration and the bond type of Pt and SCN^- is Pt-S. When the aqueous solution of the complex was stored for one week, an orange-yellow precipitation appeared, different from the complex with light yellow color. Further comparative studies of these two complexes suggested that the precipitation is cis-[Pt(NCS)₂(NH₃)₂], the linkage isomerism of cis-[Pt(SCN)₂(NH₃)₂]. The mechanism of the isomerism reaction is also discussed.