Capillary electrophoresis with direct chemiluminescence detection for the analysis of catecholamines in human urine

A rapid and sensitive method for the analysis of three catecholamines by capillary electrophoresis(CE)with directchemiluminescence(CL)detection is described.The detection limits(S/N=3)were 1.3*10-8g/mL for isoprenaline,1.0*10-8g/mL for epinephrine and 2.8*10-8g/mL for dopamine.The proposed method was successfully applied to theanalysis of catecholamines in urine samples of cigarette smokers and nonsmokers.The results showed that there is a close relationbetween the release of dopamine in human body fluids and cigarette smoking/nonsmoking.     

Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carrier via dendritic approach

To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-Fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu.     

激波管内氢-氧混合气体爆轰温度的测量

 以光纤传输光能，用多通道光学高温计，在垂直和平行于爆轰波传播方向上，测量了激波管中氢氧（或含氮）混合气体的爆轰温度。在20~53 kPa压力范围内，进行了六种初始压力氢氧混合气体的爆轰，分别测出横向温度和纵向温度；这两种温度在实验测量的误差范围内是一致的，并与正常爆轰的理论值符合得相当好。     

DSC and NMR Study on the Inclusion Complex of Lappaconitine with b-Cyclodextrin

Lappaconitine (Figure 1) is a diterpenoid alkaloid, naturally occurring in roots and rhizomes of Aconitum and delphinium1. Lap reveals bradycardic and hypotensive activity2. But its application is restrained owing to its poor water solubility, toxicity and side effects on humans. In a number of pharmaceutical studies, b-CD has been reported to interact with many drug molecules to form inclusion complexes for improving the water solubility of drugs, and reducing their toxicity3. We have p…     

H-Bonding Self-assembled Template-directed Synthesis of a Reactive Amide-bridged Ladder Polyvinylsiloxane

Ladder polysiloxanes (LPS) including both oxygen-bridged ladder polysilsesquioxanes (LPSQ) and organo-bridged ladder polysiloxanes (OLPS) are very important materials because of their excellent properties1. Adrianov et al. in 1960 attempted to prepare 1, …     

Novel Stereoselective Synthesis of (E)-a,b-Unsaturated Esters by the Tandem Reaction of Deprotonation-Oxidation-Wittig Reaction from Phosphonium and Arsonium Salt

Wittigreactionisoneofthemostimportantmethodfortheformationofcarbon-carbondoublebondandhasbeenwidelyusedinthesynthesisofnaturalproducts1,2.Recentlyitwasfoundthatalcoholscanundergoinsituoxidation-Wittigreactionwithphosponiumylidestogivecorrespondingolefinationproducts,whichhasgreatpotentialutilitiesinorganicsynthesis3.Tosimplifytheprocedureofthereactionfurther,weconsideredtocombinethedeprotonationofylide,oxidationofalcoholandWittigreactionintoonetandemreaction.Weutilizedphosphoniumorarsoniumsal…     

Structural Study of Inclusion Complex of Andrographolide with β-Cyclodextrin Prepared under Microwave Irradiation

Andrographolide (Andro) (Figure 1) is a diterpene lactone isolated from Andrographis paniculate Nees1. It has showed several biological activities including analgesic, antipyretic and anti-inflammatory effects2. However, its poor water solubility and unstability towards oxygen restrained its application. In pharmaceutics, b-CD is used to increase solubility and stability3. We have prepared the inclusion compound of Andro/b-CD (Figure 2) under microwave irradiation4. It has been found…     

A Novel Synthesis of (-)-10-epi-α-Cyperone

The eudesmane derivative, (-)-10-epi-α-cyperone 1, is widely used as a chiral starting material for the synthesis of other fused-ring sesquiterpenes1. The first synthetic work was reported by Howe and co-workers via condensation of (+)-dihydrocarvone 2 with 1-diethylaminopentan-3-one methiodide in 32% yield2. Previously, our group reported the synthesis of compound 1 by treating ketone 2 with ethyl vinyl ketone (EVK) directly under different conditions1a, but the yields were not satisfacto…     

The Inclusion Interval of Basic Coneigenvalues of a Matrix

In this paper,a compound-type inclusion interval of basic coneigenvalues of(com- plex)matrix is obtained.The corresponding boundary theorem and isolating theorem are given.     

CONSTRUCTION OF SOLUTIONS TO M-D RIEMANN PROBLEMS FOR A2×2 QUASILINEAR HYPERBOLIC SYSTEM

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