Simple and Rapid Bioink Jet Printing for Multiscale Cell Adhesion Islands

A simple and rapid process for multiscale printing of bioinks with dot widths ranging from hundreds of microns down to 0.5 μm is presented. The process makes use of spontaneous surface charges generated pyroelectrically that are able to draw little daughter droplets directly from the free meniscus of a mother drop through jetting (“p‐jet”), thus avoiding time‐consuming and expensive fabrication of microstructured nozzles. Multiscale can be easily achieved by modulating the parameters of the p‐jet process. Here, it is shown that the p‐jet allows us to print well‐defined adhesion islands where NIH‐3T3 fibroblasts are constrained to live into cluster configurations ranging from 20 down to single cell level. The proposed fabrication approach can be useful for high‐throughput studies on cell adhesion, cytoskeleton organization, and stem cell differentiation.

     

A RESIDUAL-BASED UNRESOLVED-SCALE FINITE ELEMENT MODELLING FOR IMPLICT LARGE EDDY SIMULATION 1)

对应于湍流的大尺度与小尺度流场信息, 本文在有限元的框架下, 假设Navier-Stokes方程的解的形函数由大尺度和不可解尺度形函数叠加组成, 引入对应的权函数, 将Navier-Stokes方程的有限元变分形式分解为大尺度和不可解尺度系统. 根据不可解尺度系统, 构建基于Navier-Stokes大尺度方程残差的不可解尺度模型, 将其代入Navier-Stokes方程的大尺度系统, 进而数值求解大尺度系统得到Navier-Stokes方程的大尺度解. 该方法无需像传统的大涡模拟方法那样对方程的解进行过滤, 通过对形函数进行尺度分解实现解的尺度分解. 本文使用该方法的自编程序代码开展了槽道湍流的数值模拟. 通过与有限差分大涡模拟、DNS计算结果的比较, 发现在使用较少网格情况下该方法预测的平均流向速度在近壁区与DNS数据吻合, 在黏性外层略偏高; 该方法对雷诺应力预测偏低导致从流向向垂向方向上湍动能输运略偏低. 流向速度等值面图显示该方法有效捕捉到了大尺度旋涡结构; 同时在近壁区可以观察到明显的低速条带结构.     

Multiscale Expansion Method in the Hilbert Problem

The problem of constructing an asymptotic approximation to the solution of the kinetic Boltzmann equation is considered for the hydrodynamic region of low Knudsen numbers. The problem is linearized for one-dimensional perturbations in a gas at rest. The distribution function is sought in the form of a multiscale expansion of the Hilbert asymptotic series type. The construction of a solution uniformly suitable as t is demonstrated with reference to a particular example of sonic wave propagation. It is shown that the multiscale technique makes it possible to extend the domain of applicability of the Hilbert expansion to the entire interval of dissipative relaxation.     

流体饱和多孔隙介质波动方程多尺度反演

基于多尺度的思想,将小波多分辨分析和多尺度方法相结合,应用于流体饱和多孔隙介质孔隙率的反演。利用小波变换,将原始反问题分解为不同尺度上的一系列子反问题,并按照尺度从粗到细的顺序依次求解。在每一个尺度上,都采用稳定、收敛快的正则化高斯牛顿法求解,次一级尺度上求出的“全局最优解”作为上一级的初始解,依此类推,直到求出原始问题的真正的全局最优解。通过与传统的正则化高斯牛顿法相比较,显示了小波多尺度法是一个大范围收敛、能够有效节省计算量的方法,数值模拟的结果也表明了方法的有效性。     

多传感器多尺度融合估计在组合导航系统中的应用

基于某一给定尺度上的动态系统和不同尺度上的观测系统建立了多传感器的多尺度融合估计模型及算法，并将此算法应用于GPS／INS组合导航系统中，获得了比仅在单一尺度上进行估计更好的结果，有效地提高了组合导航系统的精度。     

Multiscale fast summation of long‐range charge and dipolar interactions

Here we present a linear order multiscale method for the fast summation of long range forces in a system consisting of a large number of charge and dipolar particles. For a N‐body system, our algorithm requires an order of work that is proportional to O(N), in comparison to order O(N²) of the direct pairwise computation. Our method is demonstrated on two‐dimensional homogeneous point‐charge and dipolar systems, and a combined heterogeneous particle system, for the calculation of the induced electrostatic potential and energy. The electrostatic interaction is decomposed into a local part and a smooth part. The method thus, has several potential advantages over other O(N log N) or O(N) techniques, especially for calculation with moving particles or implicit charges locations. This approach is beneficial to large‐scale problems such as molecular statics, molecular dynamics, equilibrium statistics (Monte‐Carlo simulations), molecular docking, and in areas such as magnetism and astrophysics. © 2001 John Wiley & Sons, Inc. J Comput Chem 22: 717–731, 2001     

随机多孔复相介质稳态温度场的多尺度数值模拟

本文就随机多孔复相介质稳态温度场,提出了多尺度分析的基本思想和具体的计算公式,它们是建立在确定性温度场的多尺度算法和Ｋａｒｈｕｎｅｎ－Ｌｏｅｖｅ展开式基础上．文中算例表明这一算法的有效性。     

RECURSIVE KERNELS

This paper is an extension of earlier papers [8, 9] on the ＂native＂ Hilbert spaces of functions on some domain Ωbelong toR^d Rd in which conditionally positive definite kernels are reproducing kernels. Here, the focus is on subspaces of native spaces which are induced via subsets of Ω, and we shall derive a recursive subspace structure of these, leading to recur- sively defined reproducing kernels. As an application, we get a recursive Neville-Aitken- type interpolation process and a recursively defined orthogonal basis for interpolation by translates of kernels.     

Recursive Kernels

This paper is an extension of earlier papers [8, 9] on the “native” Hilbert spaces of functions on some domain Ω ⊂ R ^d in which conditionally positive definite kernels are reproducing kernels. Here, the focus is on subspaces of native spaces which are induced via subsets of Ω, and we shall derive a recursive subspace structure of these, leading to recursively defined reproducing kernels. As an application, we get a recursive Neville-Aitken-type interpolation process and a recursively defined orthogonal basis for interpolation by translates of kernels.