全文获取类型
收费全文 | 11683篇 |
免费 | 121篇 |
国内免费 | 67篇 |
专业分类
化学 | 4673篇 |
晶体学 | 16篇 |
力学 | 696篇 |
综合类 | 1篇 |
数学 | 4029篇 |
物理学 | 2456篇 |
出版年
2024年 | 46篇 |
2023年 | 682篇 |
2022年 | 410篇 |
2021年 | 416篇 |
2020年 | 1458篇 |
2019年 | 1069篇 |
2018年 | 930篇 |
2017年 | 756篇 |
2016年 | 736篇 |
2015年 | 568篇 |
2014年 | 740篇 |
2013年 | 2844篇 |
2012年 | 502篇 |
2011年 | 41篇 |
2010年 | 32篇 |
2009年 | 39篇 |
2008年 | 56篇 |
2007年 | 52篇 |
2006年 | 40篇 |
2005年 | 95篇 |
2004年 | 99篇 |
2003年 | 47篇 |
2002年 | 24篇 |
2001年 | 20篇 |
2000年 | 28篇 |
1999年 | 12篇 |
1998年 | 21篇 |
1997年 | 7篇 |
1996年 | 5篇 |
1995年 | 2篇 |
1994年 | 9篇 |
1993年 | 7篇 |
1991年 | 8篇 |
1990年 | 2篇 |
1989年 | 6篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1985年 | 4篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 12篇 |
1980年 | 2篇 |
1979年 | 5篇 |
1978年 | 8篇 |
1977年 | 6篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 4篇 |
1973年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
Triple-negative breast cancer (TNBC) is considered to be aggressive based on its low overall survival and disease-free rates. Currently, there is no molecular-targeted therapy. The identification of a suitable biomarker is still a research focus for TNBC at the present time. Amino acid metabolism fulfills multiple important physiological roles in humans. Their metabolic abnormalities have been reported in numerous cancer studies and amino acid pathways may also be chemotherapeutic targets. This study reports the profiling analysis of amino acids in TNBC and non-TNBC cell lines for detecting biomarkers based on the strategy of N-phosphorylation labeling with liquid chromatography–tandem mass spectrometry (LC–MS). Glutamine (Gln) was found to be significantly down-regulated in TNBC cells because it was largely absorbed and consumed in the TNBC cell lines. These results indicate faster proliferation of TNBC and higher consumption of glutamine to meet the material and energy demand, suggesting its potential role in TNBC progression. Hence, glutamine may be regarded as a biomarker and Gln-targeted approaches may become a new therapeutic strategies for TNBC. 相似文献
42.
Hideaki Murasugi Dr. Shohei Kumagai Dr. Hiroaki Iguchi Prof. Dr. Masahiro Yamashita Dr. Shinya Takaishi 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(42):9885-9891
Crystal structures of a series of organic–inorganic hybrid gold iodide perovskites, formulated as A2[AuII2][AuIIII4] [A=methylammonium (MA) ( 1 ) and formamidinium (FA) ( 2 )], A′2[I3]1−x[AuII2]x[AuIIII4] [A′=imidazolium (IMD) ( 3 ), guanidinium (GUA) ( 4 ), dimethylammonium (DMA) ( 5 ), pyridinium (PY) ( 6 ), and piperizinium (PIP) ( 7 )], systematically changed depending on the cation size. In addition, triiodide (I3−) ions were partly incorporated into the AuI2− sites of 3 – 7 , whereas they were not incorporated into those of 1 and 2 . Such a difference comes from the size of the organic cation. Optical absorption spectra showed characteristic intervalence charge-transfer bands from AuI to AuIII species, and the optical band gap increased as the size of the cation became larger. 相似文献
43.
Guangrui Chen Yuxing Yan Dr. Jie Wang Prof. Yong Sik Ok Guiyuan Zhong Prof. Bu Yuan Guan Prof. Yusuke Yamauchi 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(44):19831-19836
Mesoporous core–shell nanostructures with controllable ultra-large open channels in their nanoshells are of great interest. However, soft template-directed cooperative assembly to mesoporous nanoshells with highly accessible pores larger than 30 nm, or even above 50 nm into macroporous range, remains a significant challenge. Herein we report a general approach for precisely tailored coating of hierarchically macro-/mesoporous polymer and carbon shells, possessing highly accessible radial channels with extremely wide pore size distribution from ca. 10 nm to ca. 200 nm, on diverse functional materials. This strategy creates opportunities to tailor the interfacial assembly of irregular mesostructured nanounits on core materials and generate various core–shell nanomaterials with controllable pore architectures. The obtained Fe,N-doped macro-/mesoporous carbon nanoshells show enhanced electrochemical performance for the oxygen reduction reaction in alkaline condition. 相似文献
44.
45.
A diagnostic study q (energy transfer processes in a He-N2 flowing discharge and afterglow has been performed in a radiofrequency-produced plasma cooled in a liquid nitrogen hath. Optical emission spectroscopy in the visible and infrared spectral range as well as Langrnuir probe diagnostics were used. The vibrational kinetics of CO injected in such an afterglow has been examined. It shows a slow cooling of the electrons in the afterglow regime. The electron kinetics responsible joy CO vibrahonal excitation is turned off when N2 is added to the He discharge, while that for vibrationally excited N2 molecules is turned on. The results are discussed on the basis of previous theorerical calculations and experiments on the He-N2 system. 相似文献
46.
聚变等离子体中的快离子压强 总被引:2,自引:2,他引:0
本文运用Fokker-Planck方程的慢化近似,考虑存在多种离子成份(包括杂质),假定它们具有共同的温度,我们得到了聚变产生的快离子压强的简单封闭形式表示式。表明在典型的工作温度下(~60keV),D-~3He等离子体中聚变产生的快离子压强约为本底热压强的20%,这与D-T等离子体工作在20keV时的比值几乎相同。因此,D-~3He和D-T在它们相应的预期工作温度下,它们各自的快离子压强对总压强的影响是类似的,然而在更高的温度下,这个比值将变得更大。 相似文献
47.
D—^3He聚变动力可行性研究 总被引:9,自引:3,他引:6
本文首先简要地讨论D-3He聚变的物理要求并与D-T聚变作相应的比较,然后运用目前的约束定律和第一稳定区β极限,对计划的近期ETR规模装置(如CIT,TIBER,FER,NET)进行D-3He得失相当和点火实验的可行性研究,并对高径比第二稳定区D-3He托卡马克堆进行参数学研究,最后指出潜在的缩短商用化进程可能性。 相似文献
48.
S. De Nicola A. E. Kaplan S. Martellucci P. Mormile G. Pierattini J. Quartieri 《Applied physics. B, Lasers and optics》1989,49(5):441-444
We have observed a hysteretic (bistable) reflection of a Gaussian laser beam at the interface between glass and a liquid solution of polystyrene microspheres as nonlinear medium with both branches of the hysteretic curve being stable, in contrast to the results of previous experiments. 相似文献
49.
双折射双频激光器偏振特性的分析 总被引:6,自引:1,他引:5
用激光原理和晶体光学原理分析了腔内加旋光晶体的激光器输出光的偏振特性,实验和分析表明,激光器输出两束不同频率的垂直线偏振光,激光器两端输出光的偏振面有一夹角a,且此夹角与晶轴和传光方向的夹角θ有关。理论计算结果在双折射双频激光器的实验结果符合很好。 相似文献
50.
A. Torrisi P. Horák J. Vacík A. Cannavò G. Ceccio J. Vaniš 《Phosphorus, sulfur, and silicon and the related elements》2020,195(11):932-935
AbstractOn the perspective to develop CuO–TiO2 MOS, multilayered Cu and Ti thin layers were alternatively deposited on silicon wafers using 25?keV Ar?+?ion beam sputtering and, subsequently, oxidized by thermal annealing in air at 400?°C for 24?h. The deposited films have variable ratios of the Cu and Ti % at. One of the main goal is to obtain such multilayers avoiding the presence of Cu–Ti–O compounds. The samples were characterized in terms of composition (by RBS and SIMS analyses) and morphology (by AFM and SEM investigations). In particular, SIMS maps allows to observe the spatial distribution and thickness of each phase of the Cu/Ti multilayers, and further to observe Cu diffusion and mixing with Ti, as well as phase separation of CuO and TiO2 in the samples. The reasons of this effect represent an open issue that has to investigated, in order to improve the MOS fabrication. 相似文献