Syntheses and Crystal Structures of Benzyltin（Ⅳ） Derivatives of 2-Mercaptobenzothiazole

Introduction Metal thiolato complexes have been extensively investigated because of their ability to adopt various nuclearities and their relevance in biological science, since they form the inorganic part of the biologically active centers of some metalloproteins and enzymes.1-3 Recently, attention has been paid to the coordination chemistry of heterocyclic thiol/thione donors, which can give potential access to new compounds with unusual structures and reactivities,4 such as 2-mercaptobenzo-…     

二烷基氨荒酸二苯基锗盐的合成及性质研究

The diphenylgermanium bis-dithiocarbamates Ph₂Ge(S₂CR)₂ (I～VIII) have been synthesized by the reaction of Ph₂GeCl₂ with RCS₂Na in CH₂Cl₂ solvent. Their structures were characterized with IR, ¹H NMR, UV spectra and the in vitro antitumour activity are tested. In mentioned germanium complexes (I～VIII) the dithiocarbamatyl groups are monodentate ligands.     

Syntheses and Crystal Structure of Six－coordinated Diorgnotin Complexes with 2,5－Dimercapto－4－phenyl－1,3,4－thiodiazole

The reactions of diorganotin dichloride [Ph_2SnCl_2, (PhCH_2)_2-SnCl_2 or (n-Bu)_2SnCl_2] with potassium salt of 2,5-dimercapto-4-phenyl-1, 3, 4-thiodiazole gave complexes R_2Sn (S_3N_2C_8H_5)_2(4: R=Ph; 5: R=PhCH_2 and 6: R=n-Bu), respectively.Characterizations were carried out for all complexes by IR, ~1HNMR spectra and X-ray crystallography analysis. Including theSn…N interaction, the three complexes all have six-coordinateddistorted octahedral geometry. Based on the requence of stereo-chemical constraint sequence, phenyl≈benzyl>n-butyl, the lessthe effect of the stereochemical constraint of R groups, the     

含硫、氮配位的二正丁基锡二（二苯基卡巴腙）合成及晶体结构研究

以乙醇钠作碱，用二正丁基二氯化锡或三正丁基氯化锡与二苯基硫代卡巴腙反 应，合成了二正丁基锡二(二苯基硫代卡巴腙)[(n-Bu)_2Sn(sN_4C_13H_11)_2]．通 过元素分析、红外光谱、紫外光谱和核磁共振氢谱对其结构进行了表征．用X射线 单晶衍射测定了该化合物的晶体结构。化合物为单斜晶系，空间群P2_1／c，α=2 ．0215(7)nm，b=1．3103(5)nm，c=2．8171 (10)nm，β=95．412(7)°，Z=8， V=7．428(5)nm~3，Dc=1．330g／cm~3，μ=0．834 mm~-l， F(OOO)=3056， R_l=0．0575， wR_2=0.0959．化合物中，中心锡原子为六配位畸变八面体构型     

三烃基锡杂环羧酸酯的合成

合成了十种三烃基锡杂环羧酸酯R~3^1SnO~2C-R^2(R^1=n-C~4H~9, Ph-CH~2; R^2=呋喃, 吡啶, 吲哚烷基), 利用IR, ^1H NMR及元素分析确定了这些化合物的组成和结构。     

二苄基一氯化锡氨荒酸酯的合成与表征

合成了13个新的二苄基一氯化锡氨荒酸酯化合物(PhCH~2)~2Sn(Cl)Sn(Cl)S~2CNRR'。利用元素分析、UV、IR、^1HNMR谱和TG-DTA表征了它们的结构。初步生物活性研究表明,有些化合物表现出体外抑制白血细胞P~3~8~8生长的活性。     

三苄基锡氨荒酸酯的合成与表征

合成了15个新的三苄基锡氨荒酸酯,利用元素分析,紫外光谱,红外光谱,核磁共振氢谱以及热分析表征了它们的结构,确定了氨荒酸是以双硫形式与锡原子配位。生物活性测试结果表明,这类化合物具有一定的杀菌活性。     

二苄基锡双(吗啉荒酸酯)的合成、表征及晶体结构

Dibenzyltin bis(dithiomorpholinocarbamate) was synthesized by the reaction of dibenzyltin dichloride with dithiomorpholinocarbamate. The compound was characterized by elemental analysis, IR, ¹H NMR and MS. and the crystal structure was determined by X-ray single crystal diffraction. The crystal belongs to orthorhombic with space group Pca2₁, a=1.8327(3)nm, b= 0.65678(12)nm, c=2.2583(4)nm, Z=4, V=2.718 (9)nm³, D_x=1.528g·cm^-3,μ=1.271mm^-1, F(000)=1272, R₁=0.0434, wR₂=0.1152. In the crystals, the structures consist of discrete molecules containing six-coordinate tin atoms in a distorted octahedron configuration.     

三苄基锡二元羧酸衍生物的合成

以双(三苄基锡)氧化物和相应的二元羧酸反应,合成了14种新的三苄基锡二元羧酸衍生物.利用元素分析、IR和1HNMR表征了这些化合物的结构.生物活性测试表明该类化合物具有较好的杀菌活性.     

二苯基锗杂环羧酸酯的合成、表征及生物活性研究

合成了8种二苯基锗杂环羧酸酯Ph2Ge(O2CR)2(R=2-呋喃基、2-呋喃乙烯基、2-噻吩基、2-吡啶基、3-吡啶基、4-吡啶基、3-吲哚甲基、3-吲哚丙基),利用元素分析、红外光谱、核磁共振氢谱和质谱表征了这些化合物的结构。体外实验表明,这些化合物对MCF-7、WidDr和EC癌细胞具有较好的抑制活性。