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排序方式: 共有189条查询结果,搜索用时 515 毫秒
31.
32.
Tatyana Kovshova Nadezhda Osipova Anna Alekseeva Julia Malinovskaya Alexey Belov Andrey Budko Galina Pavlova Olga Maksimenko Shakti Nagpal Svenja Braner Harshvardhan Modh Vadim Balabanyan Matthias G. Wacker Svetlana Gelperina 《Molecules (Basel, Switzerland)》2021,26(4)
Targeted delivery of doxorubicin still poses a challenge with regards to the quantities reaching the target site as well as the specificity of the uptake. In the present approach, two colloidal nanocarrier systems, NanoCore-6.4 and NanoCore-7.4, loaded with doxorubicin and characterized by different drug release behaviors were evaluated in vitro and in vivo. The nanoparticles utilize a specific surface design to modulate the lipid corona by attracting blood-borne apolipoproteins involved in the endogenous transport of chylomicrons across the blood–brain barrier. When applying this strategy, the fine balance between drug release and carrier accumulation is responsible for targeted delivery. Drug release experiments in an aqueous medium resulted in a difference in drug release of approximately 20%, while a 10% difference was found in human serum. This difference affected the partitioning of doxorubicin in human blood and was reflected by the outcome of the pharmacokinetic study in rats. For the fast-releasing formulation NanoCore-6.4, the AUC0→1h was significantly lower (2999.1 ng × h/mL) than the one of NanoCore-7.4 (3589.5 ng × h/mL). A compartmental analysis using the physiologically-based nanocarrier biopharmaceutics model indicated a significant difference in the release behavior and targeting capability. A fraction of approximately 7.310–7.615% of NanoCore-7.4 was available for drug targeting, while for NanoCore-6.4 only 5.740–6.057% of the injected doxorubicin was accumulated. Although the targeting capabilities indicate bioequivalent behavior, they provide evidence for the quality-by-design approach followed in formulation development. 相似文献
33.
E. Yu. Osipova A. S. Ivanova A. N. Rodionov A. A. Korlyukov D. E. Arkhipov A. A. Simenel 《Russian Chemical Bulletin》2016,65(12):2868-2872
Regioselectivity of the HBF4-catalyzed ferrocenylalkylation of 2-mercaptobenzoxazole in two phase aqueous organic solvent mixture was studied. The reaction proceeds regioselectively at the heterocyclic nitrogen atom. Structures of the synthesized compounds were established by 2D NMR technique. Structure of 3-(1-ferrocenylbenzyl)benz[d]oxazol-2-thione was elucidated by X-ray diffraction. 相似文献
34.
E. Yu. Osipova A. N. Rodionov Yu. A. Belousov M. M. Il’in A. L. Nikolaev A. V. Gopin S. E. Mazina A. A. Simenel 《Russian Journal of Organic Chemistry》2016,52(1):127-130
The condensation of 1-(ferrocenylalkyl)pyrazole-3-carbaldehydes with 4′-aminotetraphenylporphyrin, followed by reduction with NaBH(OAc)3 in 1,2-dichloroethane, provides a convenient method for the synthesis of 5-{4-[({1-[1-(ferrocen-1-yl)alkyl]-5-methyl-1H-pyrazol-3-yl}methyl)amino]phenyl}-10,15,20-triphenylporphyrins which exhibit pronounced cytotoxicity against Staphylococcus aureus under ultrasonic irradiation. 相似文献
35.
V. M. Aynutdinov A. V. Avrorin V. A. Balkanov I. A. Belolaptikov D. Bogorodsky N. M. Budnev R. Wischnewski O. N. Gaponenko K. V. Golubkov O. A. Gress T. I. Gress O. G. Grishin I. A. Danilchenko Zh. -A. M. Dzhilkibaev G. V. Domogatsky A. A. Doroshenko A. Dyachok V. A. Zhukov A. M. Klabukov A. I. Klimov K. Konishchev A. Kochanov A. P. Koshechkin L. A. Kuzmichev V. F. Kulepov D. A. Kuleshov E. Middell M. B. Milenin R. R. Mirgazov S. P. Mikheyev E. A. Osipova A. I. Panfilov L. V. Pan’kov G. L. Pan’kov D. A. Petukhov E. N. Pliskovsky V. A. Poleshuk E. G. Popova P. G. Pokhil V. V. Prosin M. I. Rozanov V. Yu. Rubtsov O. V. Suvorova B. A. Tarashansky S. V. Fialkovsky B. A. Shaibonov A. A. Sheifler Ch. Spiering I. V. Yashin 《Bulletin of the Russian Academy of Sciences: Physics》2009,73(5):643-645
The status of the Baikal neutrino experiment is briefly reviewed and the results of the search for the natural flux of high-energy neutrinos are reported. 相似文献
36.
K. A. Subbotin Yu. N. Osipova D. A. Lis V. A. Smirnov E. V. Zharikov I. A. Shcherbakov 《Optics and Spectroscopy》2017,123(1):49-55
Concentration series of disordered scheelitelike Yb:NaGd(MoO4)2 and Yb:NaLa(MoO4)2 single crystals are grown by the Czochralski method. The actual concentrations of Yb3+ ions in the crystals are determined by optical-absorption spectroscopy. The luminescence of Yb3+ ions in these crystals in the region of 1 μm is studied under UV and IR excitation. In the case of UV excitation, this luminescence appears as a result of nonradiative excited state energy transfer from donor centers of unknown nature to ytterbium. The character of the concentration dependence of Yb3+ luminescence indicates that the energy transfer at high Yb concentrations occurs with active participation of a cooperative mechanism, according to which the excitation energy of one donor center is transferred simultaneously to two Yb3+ ions. In other words, the quantum yield of this transfer exceeds unity, which can be used to increase the efficiency of crystalline silicon (c-Si) solar cells. 相似文献
37.
Alferov K. V. Zhukov Yu. N. Khurs E. N. Osipova T. I. Khomutov R. M. 《Russian Chemical Bulletin》2001,50(2):316-318
A convenient procedure for the synthesis of 1-amino-3-hydroxypropylphosphinic and -phosphonic acids (analogs of homoserine) was developed. The procedure involves the reaction of salts of phosphinic and phosphonic analogs of S-methylmethionine with AcONa/AcOH followed by hydrolysis. 相似文献
38.
E. A. Osipova E. N. Shapovalova M. N. Ofitserova S. V. Podlesnykh 《Journal of Analytical Chemistry》2000,55(1):52-57
It was demonstrated that Pb(II), Cd(II), Hg(II), Ni(II), Co(II), and Cu(II) can be indirectly determined as their unithiol
complexes by amperometric detection under static and HPLC conditions. Factors affecting the Chromatographic separation and
amperometric detection of metal complexes of unithiol were studied. Two designs of flow electrochemical cells (thin-layer
and wall-jet cells) and three electrode materials (platinum, graphite, and glassy carbon) were compared. The best sensitivity
was attained for an amperometric detector with wall-jet flow cell and a graphite indicator electrode. The detection limits
for Hg(II), Pb(II), and Cd(II) were 0.9, 0.3, and 0.1 μg/mL, respectively. The Chromatographic determination of heavy metals
in a sample of waste water was carried out using the amperometric detector 相似文献
39.
Extraction and Membrane Transport Properties of 8-(1-O,O-Diamylphosphoryl-3,5-dioxapentane)quinoline
Davletshina N. V. Khabibullina A. R. Gaynullin A. Z. Davletshin R. R. Osipova E. V. Cherkasov R. A. 《Russian Journal of General Chemistry》2021,91(1):85-89
Russian Journal of General Chemistry - The membrane transport properties of P,N-containing carrier, 8-(1-diamylphosphoryl-3,5-dioxapentane)quinoline, have been studied. The relationship between the... 相似文献
40.
Petrov O. A. Osipova G. V. Aganicheva K. A. 《Russian Journal of Physical Chemistry A, Focus on Chemistry》2020,94(1):48-53
Russian Journal of Physical Chemistry A - The acid–base interaction between octa(m-trifluoromethylphenyl)porphyrazine and pyridine, 2‑methylpyridine, morpholine, and piperidine in the... 相似文献