牙周病患者头发微量元素的测定

为探讨牙周病与微量元素的关系,对28例牙周病患者头发Fe、Zn、Cu、Ca进行了测定,并与正常对照组做比较。结果表明,牙周病患者头发Fe、Zn、Cu、Ca较对照组明显降低。提示牙周病患者头发微量元素的含量与牙周病有密切关系。     

一类Gauss序列极值的极限律

本文讨论一类非平稳Gauss序列的极值．利用点过程收敛定理得到多水平超过的点过程的收敛性,同时得到在不相交区间上最大值的联合渐近分布,第k个最大值的渐近分布以及前r个极值的联合渐近状态．     

红外光谱法测定壳聚糖含量(英文)

采用吡喃环上的次甲基的吸收峰(1 389和2 865cm-1)面积比作为定量参照,建立了一种检测壳聚糖含量的傅立叶变换红外光谱(FT-IR)分析方法,并验证了其适用性.结果表明,所建立的FT-IR分析方法可用于定量测定药物剂型中的壳聚糖含量.     

多发性骨髓瘤的骨髓形态学分析与临床应用

目的研究多发性骨髓瘤的骨髓形态学特征,探讨骨髓形态学在多发性骨髓瘤诊断中的临床应用价值。方法对广东医学院附属医院63例多发性骨髓瘤病人进行骨髓涂片及细胞染色和进行检验诊断分析。结果 94%的患者骨髓增生度都达到增生活跃以上,只有6%的是增生低下或极度低下,瘤细胞数量﹥15%,根据形态可分为四类;病人骨髓其他系包括巨核系、粒系、红系和淋巴系细胞都不同程度减少和受抑制。结论骨髓形态学分析是多发性骨髓瘤诊断和治疗疗效监测具有重要的临床应用价值,具有广泛开展的必要性和意义。     

Acid-Controlled Regional Diverse Synthesis of CF3-Containing Ketoimines and Application in the Construction of Bispiro[oxindole-pyrrolidine-benzothiophenone]s

Here described an acid-controlled regional diverse synthesized process of CF₃-containing ketoimines by the condensation of benzo[b]thiophene-2,3-dione and 2,2,2-trifluoroethlamine. The imines obtained at either the 2-position or 3-position can be further used as substrates in asymmetric organocatalyzed [3+2]-cycloaddition reactions, leading to a library of regiodiverse bispiro-compounds with 85–96 % yield and 65–99 % ee.     

Asymmetric S-Michael Reaction: Synthesis of CF2H−Containing S-Ether Compounds through Isosteric Replacement

Optical pharmaceutical important compounds which bring CF₂H to mimic the role of –SH were synthesized through the asymmetric S-Michael addition reaction in the presence of quinine–a derived squaramide catalyst. Various sulfhydryl compounds including Benzyl mercaptan, phenthiol, alkyl thiophenol, mercaptoacetate, methyl 3-mercaptoacrylate, and 1,4-dithiane-2,5-diol were tested. The broad substrate scope, good functional group tolerance, and easy derivatization make this synthesis method very attractive.