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101.
LIU KaiQiang PENG JunXia XUE Min YAN Ni LIU Jing & FANG Yu* Key Laboratory of Applied Surface Colloid Chemistry Ministry of Education School of Chemistry Materials Science Shaanxi Normal University Xi’an China 《中国科学B辑(英文版)》2011,(3)
Five new diacid amides of di-cholesteryl L-glycinates were designed and prepared.The compounds with linkers containing 0,1, 2,3,or 4 methylene units are denoted as 1,2,3,4,and 5,respectively.Their gelation behaviors in 25 solvents were tested as novel low-molecular-mass organic gelators(LMOGs).It was shown that the length of the linker connecting the two-cholesteryl residues in a gelator plays a crucial role in the gelation behavior of the compound.1 gels 11 of the 25 solvents tested at a concentration lowe... 相似文献
102.
Juan Huang Jian Wei Wang Tao Gong Zhi Rong Zhang *Key Laboratory of Drug Targeting Ministry of Education West China School of Pharmacy Sichuan University Chengdu China 《中国化学快报》2007,(3)
To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-Fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu. 相似文献
103.
Cheng Quan Wang Hui Wang Yan Ming Liu* College of Chemistry Chemical Engineering Xinyang Normal University Xinyang China 《中国化学快报》2007,18(4):452-454
A rapid and sensitive method for the analysis of three catecholamines by capillary electrophoresis(CE)with directchemiluminescence(CL)detection is described.The detection limits(S/N=3)were 1.3*10-8g/mL for isoprenaline,1.0*10-8g/mL for epinephrine and 2.8*10-8g/mL for dopamine.The proposed method was successfully applied to theanalysis of catecholamines in urine samples of cigarette smokers and nonsmokers.The results showed that there is a close relationbetween the release of dopamine in human body fluids and cigarette smoking/nonsmoking. 相似文献
104.
Dong Yu ZHAO Sheng Hua YANG Ming HU Xue Yi MA* Department of Chemistry National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 《中国化学快报》2003,14(2)
Andrographolide (Andro) (Figure 1) is a diterpene lactone isolated from Andrographis paniculate Nees1. It has showed several biological activities including analgesic, antipyretic and anti-inflammatory effects2. However, its poor water solubility and unstability towards oxygen restrained its application. In pharmaceutics, b-CD is used to increase solubility and stability3. We have prepared the inclusion compound of Andro/b-CD (Figure 2) under microwave irradiation4. It has been found… 相似文献
105.
Kai Jun LIAO Xiao Hua YAN Dong Yun ZHAO Xue Yi MA* Department of Chemistry National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 《中国化学快报》2002,(3)
Lappaconitine (Figure 1) is a diterpenoid alkaloid, naturally occurring in roots and rhizomes of Aconitum and delphinium1. Lap reveals bradycardic and hypotensive activity2. But its application is restrained owing to its poor water solubility, toxicity and side effects on humans. In a number of pharmaceutical studies, b-CD has been reported to interact with many drug molecules to form inclusion complexes for improving the water solubility of drugs, and reducing their toxicity3. We have p… 相似文献
106.
Ruo Jun SUN Hui JIANG Zhi Zhen HUANG* Department of Chemistry Zhejiang University Hangzhou 《中国化学快报》2003,(3)
Wittigreactionisoneofthemostimportantmethodfortheformationofcarbon-carbondoublebondandhasbeenwidelyusedinthesynthesisofnaturalproducts1,2.Recentlyitwasfoundthatalcoholscanundergoinsituoxidation-Wittigreactionwithphosponiumylidestogivecorrespondingolefinationproducts,whichhasgreatpotentialutilitiesinorganicsynthesis3.Tosimplifytheprocedureofthereactionfurther,weconsideredtocombinethedeprotonationofylide,oxidationofalcoholandWittigreactionintoonetandemreaction.Weutilizedphosphoniumorarsoniumsal… 相似文献
107.
IBONACCISEQUENCEANDCANTOR′STERNARYSETTONGJINGCHENGSAMONS,J.ManuscriptreceivedSeptember12,1994.RevisedDecember15,1996.Depar... 相似文献
108.
109.
Pd催化的配体导向C-H键官能化反应已经成为有机化学中一种重要的合成手段. 我们用B3PW91密度泛函方法研究了Pd催化的配体导向C-H键乙酰化反应中催化剂和底物配合步骤以及C-H键活化步骤中的热力学性质. 研究发现, 具有不同导向基团的反应物之间竞争反应的选择性取决于导向基团与Pd(OAc)2的配合步骤, 配合反应稳定常数大的较容易生成乙酰化的产物. 另一方面, 反应的选择性与C-H键的活化步骤无关, 并且与导向基团的配位原子的气相碱性、原子上的电荷密度以及最高占据轨道能量都没有相关性. 相似文献
110.
Predicting Rate Constants for Nucleophilic Reactions of Amines with Diarylcarbenium Ions Using an ONIOM Method 下载免费PDF全文
The rate constants of the nucleophilic reactions between amines and benzhydrylium ions were calculated using first-principles theoretical methods. Solvation models including PCM, CPCM, and COSMORS, as well as different types of atomic radii including UA0, UAKS, UAHF, Bondi, and UFF, and several single-point energy calculation methods (B3LYP, B3P86, B3PW91, BHANDH, PBEPBE, BMK, M06, MP2, and ONIOM method) were exam-ined. By comparing the correlation between experimental rate constants and the calculated values, the ONIOM(CCSD(T)/6-311++G(2df,2p):B3LYP/6-311++G(2df,2p))// B3LYP/6-31G(d)/PCM/UFF) method was found to perform the best. This method was then employed to calculate the rate constants of the reactions between diverse amines and diarylcarbenium ions. The calculated rate constants for 65 reactions of amines with diarylcarbenium ions are in agreement with the experimental values, indicating that it is feasible to predict the rate constant of a reaction between an amine and a diarylcarbenium ion through ab initio calculation. 相似文献