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101.
Griffiths DV Al-Jeboori MJ Cheong YK Duncanson P Harris JE Salt MC Taylor HV 《Organic & biomolecular chemistry》2008,6(3):577-585
Dialkyl heteroaroylphosphonates based on thiophene, pyrrole or furan have been prepared and their reactions with trimethyl phosphite investigated. Deoxygenation of the carbonyl groups in these heteroaroylphosphonates occurs to give carbene intermediates, which then undergo further reaction. In the case of the furan-3-oylphosphonates and those systems containing a thiophene or pyrrole ring, the major reaction pathway involves intermolecular trapping of the carbene intermediates by the trimethyl phosphite, leading to the formation of ylidic phosphonates that can be readily converted into the corresponding 1,1-bisphosphonates. However, in some furan-2-oylphosphonates the carbenes generated undergo ring-opening to initially give acyclic alkynylphosphonates which may react further to give other novel phosphorus compounds. The effects of substituents on the extent to which intermolecular trapping of the initially formed carbene competes with intramolecular rearrangement has been investigated. The latter process appears to be suppressed by a substituent at the 5-position of the furan ring, the resulting ylidic phosphonates being a rare example of an efficient intermolecular trapping of a furan-2-yl carbene. 相似文献
102.
Kieran?Griffiths Albert?EscuerView authors OrcID profile George?E.?KostakisEmail author 《Structural chemistry》2016,27(6):1703-1714
This article presents the syntheses, crystal structures, topological features and magnetic properties of two NiII/NaI coordination clusters formulated [Ni 3 II Na(L1)3(HL1)(MeOH)2] (1) and [Ni 6 II Na(L1)5(CO3)(MeO)(MeOH)3(H2O)3]·4(MeOH) 2(H2O) [2 4(MeOH) 2(H2O)] where H2L1 is the semi-rigid Schiff base ligand (E)-2-(2-hydroxy-3-methoxybenzylideneamino)-phenol). Compound 1 possesses a rare Ni 3 II NaI cubane (3M4-1) topology, and compound 2 is the first example in polynuclear Ni/Na chemistry that exhibits a 2,3,4M7-1 topology. 相似文献
103.
Martin Griffiths Surajit Rajagopal 《International Journal of Mathematical Education in Science & Technology》2016,47(1):139-144
In this article, we describe the outcome of a mathematical collaboration between a university lecturer and an undergraduate student. The resulting investigation concerned a particular divisibility property of the Fibonacci numbers, and indeed it seems that a new result was found in this regard. An interesting point to be made here is that, although the mathematical content was relatively straightforward, this joint exploration did, in a very modest sense, mirror certain key aspects of the research process. 相似文献
104.
Martin Griffiths Jonny Griffiths 《International Journal of Mathematical Education in Science & Technology》2016,47(2):291-298
We study here a pair of sequences of polynomials that arise from a particular iterated mapping on the plane. We show how these sequences come about, and give some of their interesting mathematical properties. 相似文献
105.
Gonzalo Fiz Pontiveros Simon Griffiths Robert Morris David Saxton Jozef Skokan 《Combinatorica》2016,36(1):71-89
The Ramsey number r(K 3,Q n ) is the smallest integer N such that every red-blue colouring of the edges of the complete graph K N contains either a red n-dimensional hypercube, or a blue triangle. Almost thirty years ago, Burr and Erd?s conjectured that r(K 3,Q n )=2 n+1?1 for every n∈?, but the first non-trivial upper bound was obtained only recently, by Conlon, Fox, Lee and Sudakov, who proved that r(K 3,Q n )?7000·2 n . Here we show that r(K 3,Q n )=(1+o(1))2 n+1 as n→∞. 相似文献
106.
NO dissociation and subsequent N2 production in the presence of co-adsorbed S18O2 and D2 on the surface of stepped Pt(3 3 2) were studied using Fourier transform infra red reflection–absorption spectroscopy (FTIR-RAS) combined with thermal desorption spectroscopy (TDS). Reduction of NO by D (D2 is adsorbed dissociatively on Pt surfaces) proceeds to a limited extent, because this reaction is rate-controlled by NO dissociation and the supply of D atoms at the higher surface temperatures at which NO dissociation becomes significant (350 K and higher). NO–D reaction is suppressed in the presence of S18O2, depending significantly on the S18O2 coverage and the competition between the reactions NO–D and S18O2–D. When the supply of D2 is limited, e.g., 0.1 L in this study, the presence of S18O2 suppresses the NO–D reaction. With a sufficient supply of D2, e.g., 0.4 L and higher, D-atom competing reactions do not play a role any more because the reactions of both NO and S18O2 with D proceed only to a very limited extent. As such, generation of O atoms from S18O2 dissociation is the main reaction that leads to the suppression in NO dissociation and consequently, N2 production.It is also concluded that the presence of S18O2 does not seriously poison the active sites on the Pt surface, providing that there is a sufficient D supply to remove O atoms from both NO dissociation and S18O2 dissociation. 相似文献
107.
Zhen-Dan Shi Omid Motabar Ehud Goldin Ke Liu Noel Southall Ellen Sidransky Christopher P. Austin Gary L. Griffiths Wei Zheng 《Analytical and bioanalytical chemistry》2009,394(7):1903-1909
Alpha-galactosidase A hydrolyzes the terminal alpha-galactosyl moieties from glycolipids and glycoproteins in lysosomes. Mutations
in α-galactosidase cause lysosomal accumulation of the glycosphingolipid, globotriaosylceramide, which leads to Fabry disease.
Small-molecule chaperones that bind to mutant enzyme proteins and correct their misfolding and mistrafficking have emerged
as a potential therapy for Fabry disease. We have synthesized a red fluorogenic substrate, resorufinyl α-d-galactopyranoside, for a new α-galactosidase enzyme assay. This assay can be measured continuously at lower pH values, without
the addition of a stop solution, due to the relatively low pK
a of resorufin (~6). In addition, the assay emits red fluorescence, which can significantly reduce interferences due to compound
fluorescence and dust/lint as compared to blue fluorescence. Therefore, this new red fluorogenic substrate and the resulting
enzyme assay can be used in high-throughput screening to identify small-molecule chaperones for Fabry disease.
Zhen-Dan Shi and Omid Motabar contributed equally to this work 相似文献
108.
A method of comparing predicted and experimental chemical shifts was used to confirm or refute postulated structures. 1H NMR spectra returned all true positives with a false positive rate of 4%. When an analogous procedure was adopted for 13C NMR spectra, the false positive rate dropped to 1%, whereas the more practical HSQC data yielded a false positive rate of 2%. If the HSQC results were combined with 1H results, a false positive rate of 1% resulted, 4 times more accurate than 1H alone. 相似文献
109.
The aim of this tutorial review is to introduce to a broader readership the emerging technique of electrophoretic NMR (eNMR). The "electrophoretic" element of the technique refers to the fact that charged particles are induced to flow by the application of an electric field. This flow is measured using pulsed-gradient spin-echo NMR (PGSE-NMR). The great potential of this experimental approach is the fact that NMR is chemically selective and non-invasive. eNMR, especially when combined with the more established PGSE-NMR experiment, may therefore be used to quantify the structure of multi-component systems via the dynamics and charge of each species within a complex mixture. Accordingly, eNMR is likely to be of great significance for colloid scientists, biologists, technologists and formulation scientists. 相似文献
110.
Zellefrow CD Griffiths JS Saha S Hodges AM Goodman JL Paulk J Kritzer JA Schepartz A 《Journal of the American Chemical Society》2006,128(51):16506-16507
There is considerable current interest in the design of encodable molecules that regulate intracellular protein circuitry and/or activity, ideally with a high level of specificity. Src homology 3 (SH3) domains are ubiquitous components of multidomain signaling proteins, including many kinases, and are attractive drug targets because of the important role their interactions play in diseases as diverse as cancer, osteoporosis, and inflammation. Here we describe a set of miniature proteins that recognize distinct SH3 domains from Src family kinases with high affinity. Three of these molecules discriminate effectively between the SH3 domains of Src and Fyn, which are expressed ubiquitously, and two of these three activate Hck kinase with potencies that rival HIV Nef, one of the most potent kinase activators known. These results suggest that miniature proteins represent a viable, encodable strategy for selective activation of Src family kinases in a variety of cell types. 相似文献