Novel photonic technique creates micrometer resolution protein arrays and provides a new approach to coupling of genes, peptide hormones and drugs to nanoparticle carriers

We demonstrate that ultraviolet light can be used to make sterically oriented covalent immobilization of a large variety of protein molecules onto either thiolated quartz, gold or silicon. The reaction mechanism behind the reported new technology involves light-induced breakage of disulphide bridges in proteins upon UV illumination of nearby aromatic amino acids, resulting in the formation of free, reactive thiol groups that will form covalent bonds with thiol reactive surfaces. In general, the protein molecules retain their function. The size of the immobilization spot is limited to the focal point of illumination being as small as a few micrometers. This new technology allows for dense packing of different bio-molecules on a surface, allowing the creation of multi-potent functionalised new materials, such as nano-biosensors. We have developed the necessary technology for preparing large protein arrays of enzymes and fragments of monoclonal antibodies. Dedicated image processing software has been developed for making quality assessment of the protein arrays. This novel technology is ideal to couple drugs and other bio-molecules to nanoparticles which can be used as carriers into cells for therapeutic purposes.     

偏光棱镜调制器调制光强扰动的理论分析

以格兰-泰勒棱镜为例，根据实验现象对透射光强随旋转角扰动的原因进行了理论分析。实验中发现，透射光强曲线随着入射角的微小变化而偏离马吕斯定律，出现了周期性扰动。通过格兰-泰勒棱镜的单色偏振光束产生的干涉，再加上晶体-空气隙界面处反射比的因素，使得出射光强依赖于入射角。引入了扰动因子的概念，并系统讨论了扰动因子所造成的影响，从而得出了减小扰动的方法。理论研究结果与实验符合较好。为偏光棱镜的优化设计、生产及使用提供了理论基础。     

Determination of Soot Particle Size in a Premixed Flame: a Static and Dynamic Light Scattering Study

In this contribution we report upon our static and dynamic light scattering experiments to characterize soot particles in flames. We studied sooting laminar premixed flame with acetylene as fuel mixed with air as oxidizer. The air equivalence ratio of the combustion was larger than one. We used a Kaskan type burner with circular geometry and a stabilizing flow of nitrogen around the flame. We focused on the determination of the size of the soot particles in the center of the flame as a function of height above burner. In addition we investigated the influence of the mixing ratio of the gases on the size of the particles. Our results show that static light scattering is better suited than dynamic light scattering for a fast and reliable characterization of soot particles in flames. The latter needs detailed a priori information about the flame to allow the unique determination of sizes from the diffusion measurements. The soot particles grow monotonously with height above burner and with decreasing air equivalence ratio. The aggregates have a fractal dimension lower than two.     

Light level control in birefringent fibres through thermal stress effects caused by the absorption of broadside incident light: a single-ended fibre-optic system

In this paper, light level control is demonstrated using optically induced thermal stress effects in a polarization-maintaining optical fibre. The controlling light beam is absorbed by a blackened segment of the fibre and produces local heating. Light control is demonstrated in the single-ended sensor configuration, which displays a response that cannot be explained from phase delays only, but requires the addition of the coupled mode theory.     

第Ⅱ类三态叠加多模叠加态光场等幂次2m+1次方Y压缩

构造了由多模虚相干态|{iZ_j}>_q、多模虚相干态的相反态|{-iZ_j}>_q和多模真空态|{O_j}>_q这三种不同的量子光场态的线性叠加所组成的第Ⅱ类三态叠加多模叠加态光场|ψ₂⁽³⁾>_q.利用多模压缩态理论,研究了态|ψ₂⁽³⁾>_q的广义非线性等幂次2m+1次方Y压缩特性.结果发现:在压缩次数N=2m+1(m=0,1,2,3,…,…)的条件下,只要各模的初始相位和态间的初始相位差分别满足一定的取值条件,态|ψ₂⁽³⁾>_q就可呈现出周期性变化的、任意奇数次的广义非线性等幂次N次方Y压缩效应.     

Neutron dosimetry at low and high fluences with CR-39

In the Laboratory of Nuclear Microanalysis, we have developed two techniques for neutron dosimetry; the first for low fluence, the second for high fluence. These two techniques use a Solid State Nuclear Track Detector (SSNTD): the CR-39. The low fluence technique is based on the measurement of etched tracks resulting from a neutron-proton conversion. A Monte Carlo code performs a simulation of the (n,p) collision in the detector, and a numerical computer code of latent track etching allows the evaluation of the etched track parameters. The object of this is to obtain characteristics of a neutron fluence from the measured etched track parameters. When there is a high fluence and high doses, CR-39 is unsuited for optical microscopy analysis. This is because of track overlapping which makes it impossible to carry out counting and exploitation. We have therefore developed a new method permitting the reading of samples based on the measurement of the angular distribution of coherent light (He---Ne laser) transmitted through the irradiated etched SSNTD. We present these two techniques and our initial results.     

透射光牛顿环的实现和分析

提出了观察透射光牛顿环的方法，分析了透射光与反射光的牛顿环现象不同的原因。     

提高PbWO4晶体光学性能的研究

钨酸铅（ＰｂＷＯ４）晶体在生长过程中由于缺氧产生了氧空位缺陷和Ｆｅ＾２＋杂质缺陷，使晶体着色，光学性能下降，在晶体生长过程中掺进Ｓｂ２Ｏ３，能消除氧空位，将Ｆｅ＾２＋氧化为无色的Ｆｅ＾３＋，较大幅度地提高ＰｂＷＯ４晶体的光学性能和闪烁性能。     

Monotonicity of input-output mappings in inverse coefficient and source problems for parabolic equations

This article presents a mathematical analysis of input-output mappings in inverse coefficient and source problems for the linear parabolic equation ut=(kx(x)ux)+F(x,t), (x,t)∈ΩT:=(0,1)×(0,T]. The most experimentally feasible boundary measured data, the Neumann output (flux) data f(t):=−k(0)ux(0,t), is used at the boundary x=0. For each inverse problems structure of the input-output mappings is analyzed based on maximum principle and corresponding adjoint problems. Derived integral identities between the solutions of forward problems and corresponding adjoint problems, permit one to prove the monotonicity and invertibility of the input-output mappings. Some numerical applications are presented.