工程地质学发展趋势刍议

环境工程地质学是工程地质学发展的新阶段,它囊括并发展了工程地质学的所有问题。作为研究工程建设与地质环境相互作用的环境工程地质学,有待于进一步发展为工程环境灾害学──一方面,由于各种自然环境恶化和灾害间的相关性和因果性（环境恶化链、灾害链）,研究似宜不限于地质环境和灾害（当然后者仍是重点）,而适当扩大至土地环境、水环境和社会环境。作为一门应用地质学的环境工程地质学及其母学科工程环境灾害学将具有力学、地理、经济三大支柱,首先力求地质学与地理学的相互渗透和融合。另一方面,由于各种人类活动间的相关性和因果性（活动链）,所研究的人类活动似宜不限于工程建设和运行,而适当扩大至采矿和水事活动,包括开采地下水和排污。后者引起的环境恶化和灾害尤为严重,正酿成危机。其根本出路不仅在于科技进步,而且在于文化调节,力求科技与文化的相互渗透和融合。     

Effect of rotation direction of a rotary tiller on draft and power requirements in a Bangkok clay soil

Experiments were conducted in a Bangkok clay soil to evaluate the performance of a rotary tiller equipped with reverse or conventional blades. The conventional rotary tiller was equipped with C-type blades whereas the reverse-rotary tiller had new types of blades. Tests were conducted on wet land as well as in dry land. Tests were conducted at tractor forward speeds of 1.0, 1.5 and 2.0 km/h. A power-take-off (PTO) power consumed was calculated from the PTO torque and speed. The results indicated that the PTO power consumption was less for the reverse-rotary tiller compared to the conventional tiller for all passes and forward speeds. For both rotary tillers, power consumption decreased as the number of passes increased, whereas power consumption increased when the forward speed was increased. At all forward speeds, the power consumption was the highest during the first pass and lowest during the third pass. The maximum difference of PTO power requirement was after the first pass at 1.0 km/h forward speed. The reverse-rotary tiller consumed about 34% less PTO power under this condition.     

纳米载体在共负载siRNA及化疗药物对逆转肿瘤多药耐药性方面的应用

近年来,基于小干扰RNA(siRNA)的基因干扰技术从基因水平上调节与肿瘤产生多药耐药性相关的各种蛋白进而逆转化疗多药耐药性方面表现出了巨大的应用潜力。鉴于此,研究者们在RNA干扰与化疗药物的协同抗癌方面做了大量工作。但游离的siRNA在无载体的情况下不易被细胞吸收,而且会被血浆和组织中内源性的核糖核酸酶降解,因此必须将siRNA负载在载体上才能有效应用于肿瘤治疗。鉴于纳米载体的安全、高效及靶向性等优点,人们已经发展出大量能同时负载siRNA及化疗药物的纳米复合体系。本文主要评述了近年来报道的一些纳米材料在共负载siRNA及化疗药物对逆转肿瘤多药耐药性方面的应用,以及研究中经常用到的一些逆转多药耐药的作用靶点。     

Flexible lithium metal capacitors enabled by an in situ prepared gel polymer electrolyte

The rapid development of next-generation flexible electronics stimulates the growing demand for flexible and wearable power sources with high energy density. Li metal capacitor (LMC), combining with a Li metal anode and an activated carbon cathode, exhibits extremely high energy density and high power density due to the unique energy storage mechanism, thus showing great potential for powering wearable electronic devices. Herein, a flexible LMC based on an in situ prepared PETEA-based gel polymer electrolyte (GPE) was reported for the first time. Owing to the high ionic conductivity of PETEA-based GPE (5.75 × 10⁻³ S/cm at 20 °C), the assembled flexible LMC delivers a high capacitance of 210 F/g at 0.1 A/g within the voltage range from 1.5 V to 4.3 V vs. Li/Li⁺, a high energy density of 474 Wh/kg at 0.1 A/g and a high power density of 29 kW/kg at 10 A/g. More importantly, PETEA-based GPE endows the LMC with excellent flexibility and safety, which could work normally under abuse tests, such as bending, nail penetration and cutting. The in situ prepared PETEA-based GPE simplifies the fabrication process, avoids the risk of leakage and inhibits the growth of Li dendrite, making LMC a promising flexible energy storage device for the flexible electronic field.     

CZTS nanoparticles by one-pot sonochemical route – Effect of power density,pH and bath temperature

One-pot synthesis of nanosized CZTS particles using ultrasound employing citric acid as the complexing agent has been studied. The CZTS nanoparticles synthesis at different bath temperatures, pH and power densities was attempted. The power density used for the reaction did not alter the crystallinity and morphology of the synthesized particles. However, the chemical composition and the bandgap of the particles showed significant variation with the applied power density. Apart from affecting the composition, bandgap and electrical characteristics, the bath temperature considerably affected the crystallinity of the CZTS nanoparticles. Based on the conditions of synthesis, the particle size ranged between 25 ​nm and 40 ​nm. Depending on the process conditions, the bandgap of the particles varied between 1.4 ​eV and 2.9 ​eV. The samples synthesized under a power density of 46 ​W ​L⁻¹ and 40 ​°C bath temperature with reactant pH of 3.5 showed composition closer to the required stoichiometry.     

基于核酸适体的外泌体分子识别研究进展

自研究者证实外泌体承担了细胞外RNA等物质的运输功能以来, 关于外泌体来源与功能的研究一直备受关注. 近年来外泌体被发现具有作为疾病生物标志物的潜力, 使得拥有特定表面蛋白以及特定装载物的外泌体成为分析化学领域有价值的检测对象. 从化学本质角度来说, 外泌体的获取与分析需要依赖特异性的分子识别过程. 核酸适体作为分子识别单元, 因其特异性强、 亲和力高、 生物活性稳定、 易于合成和保存、 而且其序列和结构上具有可编程性, 易于设计和修饰, 已成功地用在外泌体相关的生物传感体系中. 本文从外泌体的化学组成及其具有生理、 病理意义的组分出发, 从外泌体通用生物标志物识别、癌细胞来源外泌体的检测及外泌体蛋白谱的分析这3个方面综述了以核酸适体作为分子识别单元在外泌体分析领域的代表性工作, 总结了现有的靶向外泌体的核酸适体序列信息以及应用场景, 阐述了利用化学合成与修饰以及DNA自组装等化学调控手段增强核酸适体分子识别性能的最新进展, 并从适用于外泌体分子识别的核酸适体的筛选以及化学修饰的角度, 对未来的研究方向进行了展望.     

快速稳压PSM电源主回路及补偿网络设计

针对NBI系统中单个脉冲调压电源模块(PSM)直流输出电压不可调、精度低、电压超调大,提出了在PSM电源模块输出侧串联一个调压电源的方法。为了使调压电源的系统有良好的动态性能,设计了一个TYPE-III补偿网络。最后搭建了一台样机,实验结果验证了主回路设计的正确性,为制造单个PSM电源测试台奠定了基础。     

Atomic Precise Gold Nanoclusters: Toward the Customize Synthesis,Precision Medicine

With the advantages of controllable atomic composition, unique molecular-like properties, and excellent biocompatibility, atomic precision Au cluster is an ideal candidate for developing materials with customized biological functions to meet the needs of precision medicine. To achieve the rational design of functional materials through structural regulation at the atomic level, it is important to clarify the relationship between the structure and properties of Au clusters. With the development of synthesis methodology, a variety of structural regulation methods of Au clusters have been developed, providing new opportunities for structure–activity relationship establishment and precision medicine application. This review introduces the synthesis and structure regulation methods of atomic precision Au clusters, and the effects of structural regulation on the physicochemical properties are further described. At the same time, the applications of Au clusters in precision medicine, including the detection of biomolecules, functional imaging, and disease therapy are discussed, as well as the recent studies around their biosafety. At last, it also briefly summarizes the current problems and development directions. The present work provides potential theoretical guidance for the rational design of Au clusters with customized biological functions and is of great significance for broadening their applications in the field of precision medicine.     

Hybrid output regulation for linear impulsive systems with aperiodic jumps: A discrete-time feedback controller design approach

This paper is concerned with the problem of hybrid output regulation for a class of linear impulsive systems with aperiodic jumps. Firstly, by leveraging time-dependent Lyapunov function technique and impulsive control theory, sufficient conditions for achieving output regulation are obtained in state feedback case. Then, the results are extended to error feedback case by constructing an impulsive observer. In this framework, two novel hybrid controllers are designed. Such controllers only need the discrete-time system state or error signal for feedback. The complete procedures for controller designs are also presented. Finally, two illustrative examples, including a numerical example and an LC circuit, are given to show the validity and applicability of the proposed control laws.     

Review of the design of power ultrasonic generator for piezoelectric transducer

The power ultrasonic generator (PUG) is the core device of power ultrasonic technology (PUT), and its performance determines the application of this technology in biomedicine, semiconductor, aerospace, and other fields. With the high demand for sensitive and accurate dynamic response in power ultrasonic applications, the design of PUG has become a hot topic in academic and industry. However, the previous reviews cannot be used as a universal technical manual for industrial applications. There are many technical difficulties in establishing a mature production system, which hinder the large-scale application of PUG for piezoelectric transducers. To enhance the performance of the dynamic matching and power control of PUG, the studies in various PUT applications have been reviewed in this article. Initially, the demand design covering the piezoelectric transducer application and parameter requirements for ultrasonic and electrical signals is overall summarized, and these parameter requirements have been recommended as the technical indicators of developing the new PUG. Then the factors affecting the power conversion circuit design are analyzed systematically to realize the foundational performance improvement of PUG. Furthermore, advantages and limitations of key control technologies have been summarized to provide some different ideas on how to realize automatic resonance tracking and adaptive power adjustment, and to optimize the power control and dynamic matching control. Finally, several research directions of PUG in the future have been prospected.