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961.
Jagadeesh Nagarajappa Masagalli Melanayakanakatte Kuberappa BasavanaGowda Hee-Sung Chae Won Jun Choi 《Molecules (Basel, Switzerland)》2021,26(5)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key factor in several cardiovascular diseases, as it is responsible for the elevation of circulating low-density lipoprotein cholesterol (LDL-C) levels in blood plasma by direct interaction with the LDL receptor. The development of orally available drugs to inhibit this PCSK9-LDLR interaction is a highly desirable objective. Here, we report the synthesis of naturally occurring moracin compounds and their derivatives with a 2-arylbenzofuran motif to inhibit PCSK9 expression. In addition, we discuss a short approach involving the three-step synthesis of moracin C and a divergent method to obtain various analogs from one starting material. Among the tested derivatives, compound 7 (97.1%) was identified as a more potent inhibitor of PCSK9 expression in HepG2 cells than berberine (60.9%). These results provide a better understanding of the structure–activity relationships of moracin derivatives for the inhibition of PCSK9 expression in human hepatocytes. 相似文献
962.
《Macromolecular bioscience》2018,18(5)
A method is developed that can rapidly produce blood vessel‐like structures by bonding cell‐laden electrospinning (ES) films layer by layer using fibrin glue within 90 min. This strategy allows control of cell type, cell orientation, and material composition in separate layers. Furthermore, ES films with thicker fibers (polylactic‐co‐glycolic acid, fiber diameter: ≈3.7 µm) are used as cell‐seeding layers to facilitate the cell in‐growth; those with thinner fibers (polylactic acid, fiber diameter: ≈1.8 µm) are used as outer reinforcing layers to improve the mechanical strength and reduce the liquid leakage of the scaffold. Cells grow, proliferate, and migrate well in the multilayered structure. This design aims at a new type of blood vessel substitute with flexible control of parameters and implementation of functions. 相似文献
963.
Dr. Lei Dong Mengqi Fu Prof. Lifang Liu Hai-Hao Han Prof. Yi Zang Prof. Guo-Rong Chen Jia Li Prof. Xiao-Peng He Dr. Sébastien Vidal 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(63):14445-14452
Two red-emitting dicyanomethylene-4H-pyran (DM) based fluorescent probes were designed and used for peroxynitrite (ONOO−) detection. Nevertheless, the aggregation-caused quenching effect diminished the fluorescence and restricted their further applications. To overcome this problem, tetraphenylethylene (TPE) based glycoclusters were used to self-assemble with these DM probes to obtain supramolecular water-soluble glyco-dots. This self-assembly strategy enhanced the fluorescence intensity, leading to an enhanced selectivity and activity of the resulting glyco-dot comparing to DM probes alone in PBS buffer. The glyco-dots also exhibited better results during fluorescence sensing of intracellular ONOO− than the probes alone, thereby offering scope for the development of other similar supramolecular glyco-systems for chemical biological studies. 相似文献
964.
Qingqi Huang Shanshan Zhang Huaguo Yu Huiping Liu Fanhua Xiao Huiying Liao 《Journal of polymer science. Part A, Polymer chemistry》2019,57(10):1097-1104
A series of novel phenolphthalein‐containing sulfonated poly(arylene ether phosphine oxide)s (sPAEPP) with various sulfonation degrees were synthesized by direct polycondensation. The structure of sPAEPP was confirmed by 1H‐NMR, 13C‐NMR, and IR spectroscopy. The high‐molecular weight of these polymers was determined by gel permeation chromatography (GPC). The transparent, tough, and flexible membranes could be achieved by solution casting. The macroscopic properties and microstructure of the obtained membranes were investigated in detail. The results showed that these sPAEPP membranes displayed excellent properties in terms of swelling, proton conductivity, and methanol permeability. For example, sPAEPP‐100 membrane exhibited an appropriate water uptake of 33.1%, a swelling ratio of only 11.7% (lower than 20.1% of Nafion 117), a proton conductivity of 0.11 S cm?1 (similar to that of Nafion 117) at 80 °C, and a methanol permeability of 4.82 × 10?7 cm2 s?1. Meanwhile, it also presented outstanding oxidative stability. Atomic force microscope (AFM) micrographs showed that the hydrophilic domains of the sPAEPP‐100 membrane formed connected and narrow ionic channels, which contributed to its high proton conductivity and good dimensional stability. As a result, sPAEPP‐100 membrane displays excellent application prospect for fuel cells. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019 , 57, 1097–1104 相似文献
965.
Philipp Kulas Martin Seidel Alessandro Bozzato Bernhard Schick Daniel I. Sessler Sascha Kreuer Tobias Hüppe 《Biomedical chromatography : BMC》2020,34(5):e4811
Owing to the lack of specific symptoms, diagnosis of head and neck squamous cell carcinoma (HNSCC) may be delayed. We evaluated volatile organic compounds in tumor samples from patients suffering from HNSCC and tested the hypothesis that there is a characteristic altered composition in the headspace of HNSCC compared with control samples from the same patient with normal squamous epithelium. These results provide the basis for future noninvasive breath analysis in HNSCC. Headspace air of suspected tumor and contralateral control samples in 20 patients were analyzed using ion-mobility spectrometry. Squamous cell carcinoma was diagnosed in 16 patients. In total, we observed 93 different signals in headspace measurements. Squamous cell carcinomas revealed significantly higher levels of volatile cyclohexanol (0.54 ppbv, 25th to 75th percentiles 0.35–0.86) compared with healthy squamous epithelium (0.24 ppbv, 25th to 75th percentiles 0.12–0.3; p < 0.001). In conclusion, head and neck squamous cell carcinoma emitted significantly higher levels of volatile cyclohexanol in headspace compared with normal squamous epithelium. These findings form the basis for future breath analysis for diagnosis, therapy control and the follow-up of HNSSC to improve therapy and aftercare. 相似文献
966.
Yunjie Xiang Suoping Peng Shaohui Zheng 《International journal of quantum chemistry》2020,120(1):e26047
Organic solar cell of silol dithiophene based D2-A-D1-A-D2/PC71BM (D: donor part; A: acceptor part; 1 and 2 denote different units) possesses promising power conversion efficiency. Researchers have studied D2-A-D1-A-D2 molecules carefully, including the effects of the different number of terminal thiophenes, the different central moiety (D1), and the length of the alkyl chain. However, there are few investigations, especially theoretical studies, on the influences of different A (acceptor) units on the properties of D2-A-D1-A-D2 molecule. In the present work, we have designed and modeled five new D2-A-D1-A-D2 (D2 = bithiophene and D1 = silol dithiophene) donors by changing A units (A = diketopyrrolopyrrole, naphtho[1,2-c:5,6-c′]bis[1,2,5]thiadiazole, 5-fluoro-2,1,3-benzoselenadiazole, benzobisthiadiazole, and thiazolo[5,4-d]thiazole). We have applied density functional theory (DFT) and time-dependent DFT to predict their ground-state electronic structures and the UV–vis spectra, and the open circuit voltages (Vocs) of organic solar cells of D2-A-D1-A-D2/PC71BM. Based on the calculated results, we find that bithiophene thiazolo[5,4-d]thiazole siloldithiophene (BTTS) (D2 = bithiophene, A = thiazolo[5,4-d]thiazole, D1 = silol dithiophene) possesses the highest lowest unoccupied molecular orbital (−2.60 eV) and the lowest highest occupied molecular orbital (−5.33 eV) energies, and the strongest absorption in the visible region. Besides, the solar cell of BTTS/PC71BM has the highest Voc of 1.02 V. These results indicate that it may be a promising donor. In contrast, bithiophene benzobisthiadiazole siloldithiophene (BBBS) (A = benzobisthiadiazole) has low absorption strength in the visible region, which indicates that it may not be a suitable donor material. 相似文献
967.
In this paper, the commercial monodisperse TiO2 nanoparticles with the size of 8–10 nm were successfully applied to the photoelectrode for dye-sensitized solar cells (DSCs) and the influence of the thickness of the TiO2 thin films on the photovoltaic performance of the DSCs was investigated. The result revealed that the DSCs with the TiO2 thin film thickness of 3.6, 8.0, 11.6 and 20.0 μm gave the photoelectric conversion efficiency of 3.67%, 5.92%, 6.71% and 7.03%, respectively, under the illumination of simulated AM 1.5 sunlight (100 mW cm−2). 相似文献
968.
《Current Applied Physics》2020,20(5):720-737
Roll-to-roll (R2R) production is an innovative approach and is fast becoming a very popular industrial method for high throughput and mass production of solar cells. Replacement of costly indium tin oxide (ITO), which conventionally has served as the transparent electrode would be a great approach for roll to roll production of flexible cost effective solar cells. Indium tin oxide (ITO) and fluorine-doped tin oxide (FTO) are brittle and ultimately limit the device flexibility. Perovskite solar cells (PSCs) have been the centre of photovoltaic research community during the recent years owing to its exceptional performance and economical prices. The best reported PSCs fabricated by employing mesoporous TiO2 layers require elevated temperatures in the range of 400–500 °C which limits its applications to solely glass substrates. In such a scenario developing flexible PSCs technology can be considered a suitable and exciting arena from the application point of view, them being flexible, lightweight, portable, and easy to integrate over both small, large and curved surfaces. 相似文献
969.
WANG Li WANG Liping XU Tianshu GUO Changrun LIU Chuanzhi ZHANG Hao LI Jing 《高等学校化学研究》2014,30(6):959-964
In this work, we synthesized the polypyrrole(PPy) modified gold nanoparticles and demonstrated their negligible cytotoxicity in vitro. These nanoparticles have also been demonstrated to efficiently ablate different kinds of tumor cells in vitro under the irradiation of the near-infrared laser. When the PPy modified gold nanoparticles were conjugated with the tumor-targeted molecule of 15P(sequence: SHSWHWLPNLRHYAS), these conjugates displayed hyperthermia effects on the human ovarian cancer cell line SK-OV-3 cells in vitro under the irradiation of near-infrared laser, showing great tumor-targeted treatment efficiency. To determine the potential hyperthermia effect of PPy modified gold nanoparticles or 15P-conjugate on tumor cells in vivo, the SK-OV-3 cells were used to induce the subcutaneous tumor-bearing nude mice. The significant inhibition effects of near-infrared laser mediated PPy modified gold nanoparticles or 15P-conjugate on the tumor growth were observed. These composite results suggest that the 15P-conjugated PPy modified gold nanoparticles exhibit great biocompatibility, particularly tumor-targeted effect and the effective photothermal ablation of tumor cells, which warrants the potential therapeutic value of this conjugate for further application to the in vivo localized tumor therapy. 相似文献
970.
On the accuracy of a nonlinear finite volume method for the solution of diffusion problems using different interpolations strategies 下载免费PDF全文
L.E.S. Queiroz M.R.A. Souza F.R.L. Contreras P.R.M. Lyra D.K.E. de Carvalho 《国际流体数值方法杂志》2014,74(4):270-291
In this paper, we consider a nonlinear finite volume method to solve the steady‐state diffusion equation in nonhomogeneous and non‐isotropic media. The method is nonlinear even if the original problem is linear. In its original form, the scheme is monotone, because the coefficient matrix is monotone under certain assumptions and, as a consequence, whenever the analytic operator demands, it preserves the positivity of numerical solutions. On the other hand, the scheme is unable to reproduce piecewise linear solutions exactly. In order to recover this interesting feature, we use two different interpolation strategies. In this case, even though we are unable to prove monotonicity, we show some numerical evidences that the combined method has an improved behavior, producing second order accurate solutions, even for nonhomogeneous and strongly anisotropic media. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献