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61.
E. A. Calzetta 《The European Physical Journal B - Condensed Matter and Complex Systems》2009,68(4):601-605
The thermal efficiency of the kinesin cycle at stalling is presently a matter of some debate, with published predictions ranging
from 0 [Phys. Rev. Lett. 99, 158102 (2007); Phys. Rev. E 78, 011915 (2008)] to 100% [in Molecular Motors, edited by M. Schliwa (Wiley-VCH Verlag GmbH, Weinheim (2003), p. 207]. In this note we attemp to clarify the issues involved.
We also find an upper bound on the kinesin efficiency by constructing an ideal kinesin cycle to which the real cycle may be compared. The ideal cycle has a thermal efficiency of less than one, and the real one is less
efficient than the ideal one always, in compliance with Carnot’s theorem. 相似文献
62.
R. Argentini 《Molecular physics》2018,116(21-22):3164-3172
ABSTRACTMolecular motor proteins are used in biological systems to generate directed motion. They consist of one end that can bind to and then move along a filament. The other end can then bind to a cargo that needs transporting and the motor then pulls it along. Here, we consider the energetics of this process allowing for the friction force exerted by the surrounding fluid, given that the process takes place in a confined geometry. In nature, not all motor/cargo complexes are bound to the filament, many are in solution. Here, we address the question of whether this can be energetically favourable given that the unbound complexes will be transported by the flow generated by those that are bound. A simple theory suggests that this is the case and that there exists an optimal coverage of bound complexes. Simulations of a model of this system that includes all the relevant hydrodynamic effects confirm that the assumptions in the theory are valid so long as the coverage of bound complexes is not too low. Using realistic values for the parameters involved yields an optimal coverage that is plausible for the biological systems involved. 相似文献
63.
64.
Processive motor proteins such as kinesin and myosin-V are enzymes that use the energy of ATP hydrolysis to travel along polar cytoskeletal filaments. One of the functions of these proteins is the transport of vesicles and protein complexes that are linked to the light chains of the motors. Modeling the light chain by a linear elastic spring, and using the two-state model for one- and two-headed molecular motors, we study the influence of thermal fluctuations of the cargo on the motion of the motor-cargo complex. We solve numerically the Fokker-Planck equations of motor motion, and find that the mean velocity of the motor-cargo complex decreases monotonously as the spring becomes softer. This effect is due to the random force of thermal fluctuations of the cargo disrupting the operation of the motor. Increasing the size (thus, the friction coefficient) of the cargo also decreases the velocity. Surprisingly, we find that for a given size of the cargo, the velocity has a maximum for a certain friction of the motor. We explain this effect by the interplay between the characteristic length of thermal fluctuations of the cargo on a spring, the motor diffusion length, and the filament period. Our results may be relevant for the interpretation of single-molecule experiments with molecular motors (bead assays), where the motor motion is observed by tracking of a bead attached to the motor. 相似文献
65.
将模糊控制方法与滑模控制方法相结合,针对燃气流量调节伺服系统设计一种基于模糊切换增益调节的滑模控制器,固冲发动机流量调节伺服控制系统的不确定部分通过滑模控制器来补偿,从而可实现固冲发动机流量调节伺服系统的鲁棒控制。使用matlab对固冲发动机流量调节伺服系统进行建模仿真并与单纯使用滑模控制方法进行比较,仿真结果表明基于模糊切换增益调节的固冲发动机模糊滑模控制系统具有较好的给定适应性和抗干扰性,采用该控制方案能有效的抑制系统随机干扰对控制系统的不利影响,控制效果优于纯滑模控制方法,消弱了控制信号的抖振,为提高固冲发动机流量调节控制系统的动态性能奠定基础。 相似文献
66.
67.
Hirotaka Sato 《Tetrahedron letters》2005,46(33):5537-5541
We report the synthesis of the fluorescence-labeled probe 2 based on phyllanthurinolactone 1, which is a leaf-closing substance of Phyllanthus urinaria L. Bioorganic studies using probe 2 showed leaf-closing activity at 1 × 10−5 M, which was one-hundredth of that of the natural product 1. The fluorescence study using 2 revealed that the target cell for 1 is a motor cell and suggested that some receptors for 1 exist on the plasma membrane of the motor cell as with leaf-opening substances. 相似文献
68.
Mitotic Kinesin motors, Eg5 and Kif15, have recently emerged as good targets for cancer as they play an inevitable role during mitosis. But, most of the Eg5 inhibitors were found ineffective when the cancer cells develop resistance to them by escalating the expression of Kif15 as alternative to Eg5. Therefore, the drugs that target Kif15 became necessary to be used either as a single or in combination with Eg5 inhibitors. The present study used 39 dihydropyrazole and 13 dihydropyrrole derivatives that were having in vitro inhibitory potential against kinesin motors to develop a common pharmacophore hypothesis AHRR and atom-based QSAR model. The model was used for virtual screening of ZINC database and the resultant hits were docked against Kif15. The four drug candidates with high docking score were examined for their activity and pharmacokinetic behaviour. Based on the results these drugs could be considered as lead candidates in further drug development for cancer. 相似文献
69.
This article draws a bow from the fundamentals of the flame chemistry to combustion in engines. Aspects of radical chemistry, pollutant formation and combustion are highlighted. Concepts of current and future internal combustion engines are presented. A main focus lies on pollutant formation and reduction (CO2, CO, NOx, HC and soot). Finally, a vision of the future role of the internal combustion engine with respect to fuel cell and electrical engine is outlined. 相似文献
70.
S. Taneri M. Cemal Yalabık 《The European Physical Journal B - Condensed Matter and Complex Systems》2001,22(3):403-407
We implement a model to represent the effect of the deformation of the backbone of a system of motor proteins while sliding
on a track filament. This model incorporates a nearest neighbor interaction term among the motors for the deformation energy.
Correlations induced by this term result in increased motor force for inter-particle distances small compared to the ratchet
period.
Received 20 February 2001 and Received in final form 31 May 2001 相似文献