Simultaneous determination of econazole nitrate, main impurities and preservatives in cream formulation by high performance liquid chromatography

A reversed-phase high performance liquid chromatographic (RP-HPLC) method for determination of econazole nitrate, preservatives (methylparaben and propylparaben) and its main impurities (4-chlorobenzyl alcohol and alpha-(2,4-dichlorophenyl)-1H-imidazole-1-ethanol) in cream formulations, has been developed and validated. Separation was achieved on a column Bondclone^® C18 (300 mm × 3.9 mm i.d., 10 μm) using a gradient method with mobile phase composed of methanol and water. The flow rate was 1.4 mL min⁻¹, temperature of the column was 25 °C and the detection was made at 220 nm. Miconazole nitrate was used as an internal standard. The total run time was less than 15 min. The analytical curves presented coefficient of correlation upper to 0.99 and detection and quantitation limits were calculated for all molecules. Excellent accuracy and precision were obtained for econazole nitrate. Recoveries varied from 97.9 to 102.3% and intra- and inter-day precisions, calculated as relative standard deviation (R.S.D.), were lower than 2.2%. Specificity, robustness and assay for econazole nitrate were also determined. The method allowed the quantitative determination of econazole nitrate, its impurities and preservatives and could be applied as a stability-indicating method for econazole nitrate in cream formulations.     

Efficient Removal of Antibiotic Resistance Genes through 4f-2p-3d Gradient Orbital Coupling Mediated Fenton-Like Redox Processes

Peroxymonosulfate (PMS) mediated radical and nonradical active substances can synergistically achieve the efficient elimination of antibiotic resistance genes (ARGs). However, enhancing interface electron cycling and optimizing the coupling of the oxygen-containing intermediates to improve PMS activation kinetics remains a major challenge. Here, Co doped CeVO₄ catalyst (Co−CVO) with asymmetric sites was constructed based on Ce 4f−O 2p−Co 3d gradient orbital coupling. The catalyst achieved approximately 2.51×10⁵ copies/mL of extracellular ARGs (eARGs) removal within 15 minutes, exhibited ultrahigh degradation rate (k=1.24 min⁻¹). The effective gradient 4f-2p-3d orbital coupling precisely regulates the electron distribution of Ce−O−Co active center microenvironment, while optimizing the electronic structure of Co 3d states (especially the occupancy of e_g), promoting the adsorption of oxygen-containing intermediates. The generated radical and nonradical generated by interfacial electron cycling enhanced by the reduction reaction of PMS at the Ce site and the oxidation reaction at the Co site achieved a significant mineralization rate of ARGs (83.4 %). The efficient removal of ARGs by a continuous flow reactor for 10 hours significantly reduces the ecological risk of ARGs in actual wastewater treatment.     

一种新型光学模式转换器

提出了一种梯度折射率分布介质为基质的单体光学模式转换器,可以将两正交截面内瑞利长度相同、光腰重合的厄米-高斯光束转换为拉盖尔-高斯光束.这种转换器具有一体化且只有两个反射面的特点,因此易于调整、光能反射损耗小;对于两正交截面内瑞利长度不同、光腰不重合的厄米-高斯光束,提出了一种可调节其瑞利长度和光腰位置的光腰调节器,将光腰调节器与单体光学模式转换器组合使用,也可以将这种厄米-高斯光束转换为拉盖尔-高斯光束.     

磁场对多孔介质方腔内空气热磁对流的影响

数值分析了微重力下圆形载流线圈倾斜时多孔介质方腔内空气热磁对流. 磁场计算采用毕奥--萨伐定律求解; 动量方程与能量方程分别采用达西模型与局部热非平衡模型求解. 计算结果表明随着磁场力数\gamma 数和Da数的增加, 方腔内对流变得越来越强. 线圈倾斜角x_{\rm euler}从0^\circ到90^\circ变化时, 对流结果关于x_{\rm euler}=45^\circ呈现对称分布. Nu_{\rm m}数随线圈倾斜角的改变而变化且每个工况下局部最大Nu_{\rm m}数出现在x_{\rm euler}=45^\circ. 局部最小Nu_{\rm m}数出现在x_{\rm euler}=0^\circ, 90^\circ.      

亥姆霍兹线圈为矩形时两线圈之间磁场分布的分析

利用Matlab软件数值模拟了亥姆霍兹线圈为矩形时两线圈之间的磁场分布．该方法具有直观、形象、物理图像清晰的特点．利用Matlab数值模拟能有效地进行数值实验的教学活动．     

A second strain gradient elasticity theory with second velocity gradient inertia – Part II: Dynamic behavior

This paper is the sequel of a companion Part I paper devoted to the constitutive equations and to the quasi-static behavior of a second strain gradient material model with second velocity gradient inertia. In the present Part II paper, a multi-cell homogenization procedure (developed in the Part I paper) is applied to a nonhomogeneous body modelled as a simple material cell system, in conjunction with the principle of virtual work (PVW) for inertial actions (i.e. momenta and inertia forces), which at the macro-scale level takes on the typical format as for a second velocity gradient inertia material model. The latter (macro-scale) PVW is used to determine the equilibrium equations relating the (ordinary, double and triple) generalized momenta to the inertia forces. As a consequence of the surface effects, the latter inertia forces include (ordinary) inertia body forces within the bulk material, as well as (ordinary and double) inertia surface tractions on the boundary layer and (ordinary) inertia line tractions on the edge line rod; they all depend on the acceleration in a nonstandard way, but the classical laws are recovered in the case of no higher order inertia. The classical linear and angular momentum theorems are extended to the present context of second velocity gradient inertia, showing that the extended theorems—used in conjunction with the Cauchy traction theorem—lead to the local force and moment (stress symmetry) motion equations, just like for a classical continuum. A gradient elasticity theory is proposed, whereby the dynamic evolution problem for assigned initial and boundary conditions is shown to admit a Hamilton-type variational principle; the uniqueness of the solution is also discussed. A few simple applications to wave propagation and dispersion problems are presented. The paper indicates the correct way to describe the inertia forces in the presence of higher order inertia; it extends and improves previous findings by the author [Polizzotto, C., 2012. A gradient elasticity theory for second-grade materials and higher order inertia. Int. J. Solids Struct. 49, 2121–2137]. Overall conclusions are drawn at the end of the paper.     

Inspection of free energy functions in gradient crystal plasticity

The dislocation density tensor computed as the cud of plastic distortion is regarded as a new constitutive variable in crystal plasticity. The dependence of the free energy function on the dislocation density tensor is explored starting from a quadratic ansatz. Rank one and logarithmic dependencies are then envisaged based on considerations from the statistical theory of dislocations. The rele- vance of the presented free energy potentials is evaluated from the corresponding analytical solutions of the periodic two-phase laminate problem under shear where one layer is a single crystal material undergoing single slip and the second one remains purely elastic.     

Surface waves at the interface between an inviscid fluid and a dipolar gradient solid

This paper is about the dispersion analysis of surface waves propagating at the interface between an inviscid fluid and a higher gradient homogeneous elastic solid modelled as a dipolar gradient continuum. In order to compare the results, a second gradient model is also evaluated. The analysis is carried out by finding the roots of the secular equation, and by carefully studying their physical meaning. As it is well known, higher gradient continua are dispersive, i.e. phase and group velocities are frequency dependent. As a consequence, the existence of surface waves will indeed depend on frequency. In order to investigate the behaviour of surface waves in this specific fluid–solid configuration, a complete dispersion analysis is performed, with a particular focus on the frequency range in which the phase velocity of shear waves is lower than the speed of waves of the fluid. Surface waves of the type Leaky Rayleigh and Scholte–Stoneley are observed in this frequency range. This work extends the knowledge on surface waves in the case of higher gradient solids and applications of these results can be found in the field of non-destructive damage evaluation in micro structured materials, composites, metamaterials and biological tissues.     

Impact toughness of a gradient hardened layer of Cr5Mo1V steel treated by laser shock peening

Laser shock peening (LSP) is a widely used surface treatment technique that can effectively improve the fatigue life and impact toughness of metal parts. Cr5Mo1V steel exhibits a gradient hardened layer after a LSP process. A new method is proposed to estimate the impact toughness that considers the changing mechanical properties in the gradient hardened layer. Assuming a linearly gradient distribution of impact toughness, the parameters controlling the impact toughness of the gradient hardened layer were given. The influences of laser power densities and the number of laser shots on the impact toughness were investigated. The impact toughness of the laser peened layer improves compared with an untreated specimen, and the impact toughness increases with the laser power densities and decreases with the number of laser shots. Through the fracture morphology analysis by a scanning electron microscope, we established that the Cr5Mo1V steel was fractured by the cleavage fracture mechanism combined with a few dimples. The increase in the impact toughness of the material after LSP is observed because of the decreased dimension and increased fraction of the cleavage fracture in the gradient hardened layer.