Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide-Activated Sirtuin 7**

The sirtuins are NAD⁺-dependent lysine deacylases, comprising seven isoforms (SIRT1–7) in humans, which are involved in the regulation of a plethora of biological processes, including gene expression and metabolism. The sirtuins share a common hydrolytic mechanism but display preferences for different ϵ-N-acyllysine substrates. SIRT7 deacetylates targets in nuclei and nucleoli but remains one of the lesser studied of the seven isoforms, in part due to a lack of chemical tools to specifically probe SIRT7 activity. Here we expressed SIRT7 and, using small-angle X-ray scattering, reveal SIRT7 to be a monomeric enzyme with a low degree of globular flexibility in solution. We developed a fluorogenic assay for investigation of the substrate preferences of SIRT7 and to evaluate compounds that modulate its activity. We report several mechanism-based SIRT7 inhibitors as well as de novo cyclic peptide inhibitors selected from mRNA-display library screening that exhibit selectivity for SIRT7 over other sirtuin isoforms, stabilize SIRT7 in cells, and cause an increase in the acetylation of H3 K18.     

A study on the triboelectric charging of display glass during the roller transfer process–modeling and characterization

Glass substrates for displays are insulating materials capable of generating and maintaining high levels of triboelectric charges posing a risk of electrostatic discharge (ESD) damage to electronic display components. In this work, an apparatus for triboelectric charging characterization of display glass during the roller transfer process was designed and fabricated. In order to establish the reliability of the characterization, the triboelectric charge and the electrostatic potential distribution measurement system was automated. The preconditioning process of the glass and the rollers was also addressed. In order to analyze the measurements' results, a multiphysics model that considered both electrical and mechanical properties was proposed. The test parameters that were expected to affect the triboelectric charging characteristics are defined and discussed, as well as some of the characterization results such as the effects of acceleration/deceleration and maximum velocity, relative humidity and moisture on the glass and the rollers, and the conductivity of the rollers. The peak-to-peak deviation of the de-embedded triboelectric charges, due to a steady-state velocity period with different combinations of acceleration/deceleration and maximum velocities, was 14.2%. The triboelectric charges increased as the relative humidity increased from 30% to 50% with the same temperature. They also increased when the insulating rollers were replaced with dissipative rollers.     

偏振显示及椭圆偏振光测量实验

以单束正交线偏振光为光源,利用角向偏振显示器,采用CCD摄像机进行图像采集,利用Matlab软件进行图像处理,设计了一种由He-Ne激光器、角向偏振显示器组成的偏振光偏振方向显示系统,并研究了其角度特性.实验结果表明:系统在起偏器的起偏角分别为0°、90°、180°、270°、360°时,角向偏振显示器偏振显示角度的测量准确度分别为0.480°、0.168°、0.528°、0.421°、0.340°,测量精确度分别为0.208°、0.576°、0.660°、0.603°、0.466°,测量数据拟合曲线的线性相关系数为0.999.结合1/4波片,检偏器和分光比为50:50的分束器,构建了椭圆偏振光测量系统,完成了椭圆偏振光测量实验,椭圆率为0.198.     

一种新颖微型液晶显示器背光设计技术

针对目前机载头盔显示系统中的微型液晶显示器背光模组亮度和均匀性不足问题,提出了一种新颖的微型液晶显示器背光结构及设计理论,并通过CODEV软件设计了背光光学系统,利用LIGHTTOOLS软件对背光模组进行了配光效果仿真,结果证明当采用85 lm绿色LUXEON Rebel LEDS作光源时,其输出光亮度接近160 000 cd/m²,均匀性大于85％,功耗仅有1.25 W,完全满足了机载头盔显示系统的要求.     

Recycling of undiffracted laser light for reconstruction of holograms

When a laser source is used to illuminate a transmission hologram, the zero order beam is not utilised and is just wasted. The paper describes a new technique for economical utilisation of laser light by recycling the transmitted light to reconstruct a number of holograms simultaneously for viewing by a large number of observers. There is no danger to viewer who is exposed to the undiffracted laser beams transmitted through the hologram. The paper also discusses the diffraction efficiency requirement of successive hologram and the limit of number of holograms in the scheme.     

数字式声呐大动态范围显示技术研究

量化比特数是衡量数字声呐性能的主要指标，增加比特数意味着更高的精度和更大的动态范围，但人机视觉接口只能显示有限字长的数据。本文从声呐显示技术出发，分析了突破这一局限的必要和可能。原理分析表明，对声呐数据实行过零基准处理，以ＧＳＣ算法配合小信号分层处理可有效地获得多比特位声呐数据的几乎无损的显示，对１６比特呐数据处理显示的实验结果表明，我们的处理方法达到了预斯要求。     

基于真实情境组织教学 发展学生的核心素养——以“全球性的环境问题——酸雨”教学为例

针对教学实际中发现学生眼高手低、只知其一不知其二的问题，以二氧化硫的教学为例，提出基于生产、生活中有关二氧化硫的真实情境为背景来组织课堂教学。在教学中，依照“提出问题、师生活动、学生交流汇报、教师释疑解惑、共同总结整理”的程序实施教学，在细化了的、有目的的、多方位的有序互动中，充分激发学生的好奇心和求知欲，完善学生的知识结构，培养关键能力，形成必备品格。     

LED背光显示器对不同年龄人视网膜照度、节律效应和蓝光危害的影响

研究了视网膜照度、节律效应和蓝光危害随年龄的变化规律.采用光谱仪测量了4款常见发光二极管背光显示器显示白色和蓝色时的归一化光谱分布,然后结合不同年龄人眼的晶状体透射谱,计算了视网膜照度因子、节律因子和蓝光危害能效因子,得到三者与年龄的变化规律.研究表明:对于同一发光二极管背光显示器,视网膜照度因子、节律因子和蓝光危害能效因子均随年龄的增加而显著减小;同一人眼的视网膜照度因子随显示器类型的变化较小;对于年轻人,不同类型显示器的蓝光危害能效因子和节律因子差异明显,特别是显示蓝色时,但是,对于老年人,不同类型显示器的蓝光危害能效因子和节律因子差异较小.