Quinazoline Derivatives Designed as Efflux Pump Inhibitors: Molecular Modeling and Spectroscopic Studies

Multidrug resistance of bacteria is a worrying concern in the therapeutic field and an alternative method to combat it is designing new efflux pump inhibitors (EPIs). This article presents a molecular study of two quinazoline derivatives, labelled BG1189 and BG1190, proposed as EPIs. In silico approach investigates the pharmacodynamic and pharmacokinetic profile of BG1189 and BG1190 quinazolines. Molecular docking and predicted ADMET features suggest that BG1189 and BG1190 may represent attractive candidates as antimicrobial drugs. UV-Vis absorption spectroscopy was employed to study the time stability of quinazoline solutions in water or in dimethyl sulfoxide (DMSO), in constant environmental conditions, and to determine the influence of usual storage temperature, normal room lighting and laser radiation (photostability) on samples stability. The effects of irradiation on BG1189 and BG1190 molecules were also assessed through Fourier-transform infrared (FTIR) spectroscopy. FTIR spectra showed that laser radiation breaks some chemical bonds affecting the substituents and the quinazoline radical of the compounds.     

Numerical modelling and analysis of external gear pumps by applying generalized control volumes

Components in gear pumps usually involve complex geometrical arrangements in order to achieve the desired performance. The use of lumped parametric models is considered the most accurate and effective method for investigation of the associated design issues. In this study, the numerical modelling approach based on the lumped parameters and control volume concepts is reviewed, especially for gear teeth within the meshing zone. To apply the approach to the entire gear pump, control volume concepts are generalized to all gear pockets and flow orifices with some reasonable assumptions. The assumptions include instantaneous angular positions, orifice transitions and imagined control volumes with internal flows. The fluid dynamics and pump performance, which even have the measurement difficulties, can be estimated to investigate and optimize the design parameters of gears by the model. A simulation example and its experimental results of a gear machine are presented to validate the proposed approach in this article.     

宽带FRA中同时实现信号增益与噪声平坦的快速算法

首先优化了多波抽运拉曼光纤放大器的功率耦合方程,并利用小信号方法解决反向抽运的边值问题,其次采用遗传算法同时实现了信号增益谱和噪声谱的平坦.计算表明:双向抽运方式下系统噪声谱在C L波段(1.53~1.61μm)比反向抽运更为平坦;抽运光数目与增益平坦度呈非线性关系并存在下限值.通过多次测试,对于10波抽运,100信道的DWDM系统(带宽为80 nm),增益波动小于1 dB的优化时间可控制在400 s以内.     

海洋结构物摩擦学问题的研究进展

海洋结构物主要包括海上钻井平台、油气开采平台、FPSO、海底输油管线及海上大型储油罐等大型海上结构物.海洋结构物总是处于波浪、海流、风暴、海冰等严峻海洋环境中,并受到海生物污损、海洋腐蚀、磨损等多方面因素相互作用的影响,摩擦学问题无处不在.论文针对海洋平台结构、流体处理及运输设备、定位设备及作业设备四方面的摩擦学问题进行论述,主要介绍了海洋平台结构、管道系统及海水泵、锚链及螺旋桨、钻井套管及电潜泵等海工设备的工作特点,概述了国内外关于这类海工设备的摩擦学问题的研究现状,并对海洋结构物的摩擦学研究重点进行了展望.     

基于经验小波变换和卷积神经网络的水泵水轮机无叶区流态特征提取及识别研究

监测和识别原型水泵水轮机无叶区的流动状态,对于保证抽水蓄能电站的运行安全性和稳定性有非常重要的意义。本文提出了一种基于经验小波变换、散布熵和卷积神经网络原理的流态特征提取和识别方法,首先使用经验小波变换对压力脉动信号进行分解,然后通过计算各分量的散布熵提取流态相关特征,最后通过利用特征–标签对训练卷积神经网络得到的智能识别模型,实现了无叶区流态识别。利用从国内某水泵水轮机采集到的发电、抽水和空转工况下实测压力脉动信号对该方法进行了测试,测试的平均准确率达到了94.84%,证明了该方法的有效性。

     

A boosted voltage generator for low-voltage DRAMs

This paper proposes a new two-stage two-phase VPP charge pump configured in such a manner that the body effect and the threshold voltage loss are eliminated. The newly proposed circuit is fabricated using 0.18 μm triple-well CMOS process and the measurement result shows that the VPP level tracks 3VDD when VDD is above the threshold voltage.     

中高温热泵新工质HTR02实验研究

本文从中高温水源热泵对制冷剂的特殊要求入手,通过研究工质的性质、材料相容性、油溶性,开发了一种综合性能较好的混合工质HTR02。通过对新工质在中高温水源热泵试验台机组的大量热工性能试验以及对试验结果的误差和性能分析,表明该工质能够产生75℃左右的热水,有较高的性能系数,具有很好的应用前景;最后还引用比容积压缩功的方法讨论了新工质充灌原有R134a压缩机时的匹配问题。     

Effect of Pump Bandwidth: Enhancement of Output Intensity Noise Squeezing in Raman Lasers

The effect of the pump bandwidth on the quantum statistical properties of Raman lasers is investigated. It is shown that the pump bandwidth may lead to the enhancement of output intensity noise squeezing even though it reduces the Mandel Q parameter.     

半导体激光泵浦预激光锁模调Q固体激光器研究

报道半导体激光侧面泵浦预激光锁模调Ｑ的Ｎｄ：ＹＡＧ固体板条激光器，预激光锁模调Ｑ的激光脉冲宽度为３６ｐｓ，调Ｑ包纤各心的锁模单脉冲能量超过７μＪ，相应的峰值功率达２００ｋＷ。     

激光二极管抽运氦气冷却钕玻璃叠片激光放大器热致波前畸变和应力双折射的数值模拟和实验研究

热效应仍是限制激光放大器向高功率、高光束质量进一步发展的瓶颈问题, 高效的热管理是抑制热效应的重要技术途径. 研究了基于激光二极管抽运氦气冷却的钕玻璃叠片激光放大器的热效应. 利用有限元数值模拟的方法, 分析了钕玻璃的温度、应力应变和应力双折射分布, 并计算了热致波前畸变和退偏损耗, 与实验结果符合得较好, 在热沉积为0.7 W/cm³的条件下, 6片钕玻璃总的热致波前畸变为6.77λ , 最大退偏量大于90%.