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排序方式: 共有214条查询结果,搜索用时 31 毫秒
61.
Dr. Charlotte S. Teschers Prof. Dr. Ryan Gilmour 《Angewandte Chemie (International ed. in English)》2023,62(3):e202213304
Automated glycan assembly (AGA) on solid support has become invaluable in reconciling the biological importance of complex carbohydrates with the persistent challenges associated with reproducible synthesis. Whilst AGA platforms have transformed the construction of many natural sugars, validation in the construction of well-defined (site-selectively modified) glycomimetics is in its infancy. Motivated by the importance of fluorination in drug discovery, the biomedical prominence of 2-fluoro sugars and the remarkable selectivities observed in fluorine-directed glycosylation, fluorine-directed automated glycan assembly (FDAGA) is disclosed. This strategy leverages the fluorine atom for stereocontrolled glycosylation on solid support, thereby eliminating the reliance on O-based directing groups. The logical design of C2-fluorinated mannose building blocks, and their application in the fully (α-)stereocontrolled automated assembly of linear and branched fluorinated oligomannosides, is disclosed. This operationally simple strategy can be integrated into existing AGA and post-AGA protocols to augment the scope of programmed carbohydrate synthesis. 相似文献
62.
Peiyang Gu Xiaobo Luo Shiyuan Zhou Danfeng Wang Zhongyu Li Yu Chai Yuzhe Zhang Shaowei Shi Thomas P. Russell 《Angewandte Chemie (International ed. in English)》2023,62(36):e202303789
Stabilizing liquids based on supramolecular assembly (non-covalent intermolecular interactions) has attracted significant interest, due to the increasing demand for soft, liquid-based devices where the shape of the liquid is far from the equilibrium spherical shape. The components comprising these interfacial assemblies must have sufficient binding energies to the interface to prevent their ejection from the interface when the assemblies are compressed. Here, we highlight recent advances in structuring liquids based on non-covalent intermolecular interactions. We describe some of the progress made that reveals structure–property relationships. In addition to treating advances, we discuss some of the limitations and provide a perspective on future directions to inspire further studies on structured liquids based on supramolecular assembly. 相似文献
63.
Prof. Jing Yang Yuan Liang Xiang Li Yongpeng Zhang Prof. Long Qian Prof. Yonggang Ke Prof. Cheng Zhang 《Angewandte Chemie (International ed. in English)》2023,62(43):e202308797
Programmable assembly of gold nanoparticle superstructures with precise spatial arrangement has drawn much attention for their unique characteristics in plasmonics and biomedicine. Bio-inspired methods have already provided programmable, molecular approaches to direct AuNP assemblies using biopolymers. The existing methods, however, predominantly use DNA as scaffolds to directly guide the AuNP interactions to produce intended superstructures. New paradigms for regulating AuNP assembly will greatly enrich the toolbox for DNA-directed AuNP manipulation and fabrication. Here, we developed a strategy of using a spatially programmable enzymatic nanorobot arm to modulate anisotropic DNA surface modifications and assembly of AuNPs. Through spatial controls of the proximity of the reactants, the locations of the modifications were precisely regulated. We demonstrated the control of the modifications on a single 15 nm AuNP, as well as on a rectangular DNA origami platform, to direct unique anisotropic AuNP assemblies. This method adds an alternative enzymatic manipulation to DNA-directed AuNP superstructure assembly. 相似文献
64.
Dr. Craig P. Yu Akito Yamamoto Dr. Shohei Kumagai Prof. Jun Takeya Prof. Toshihiro Okamoto 《Angewandte Chemie (International ed. in English)》2023,62(4):e202206417
Synthetically versatile electron-deficient π-electron systems are urgently needed for organic electronics, yet their design and synthesis are challenging due to the low reactivity from large electron affinities. In this work, we report a benzo[de]isoquinolino[1,8-gh]quinoline diamide (BQQDA) π-electron system. The electron-rich condensed amide as opposed to the generally-employed imide provides a suitable electronic feature for chemical versatility to tailor the BQQDA π-electron system for various electronic applications. We demonstrate an effective synthetic method to furnish the target BQQDA parent structure, and highly selective functionalization can be performed on bay positions of the π-skeleton. In addition, thionation of BQQDA can be accomplished under mild conditions. Fine-tuning of fundamental properties and supramolecular packing motifs are achieved via chemical modifications, and the cyanated BQQDA organic semiconductor demonstrates a high air-stable electron-carrier mobility. 相似文献
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66.
Herein, we reported a new kind of naphthalimide-based derivative (N1), which could undergo direct sol–gel transition accelerated by ultrasound in 2-methoxyethanol. The gels are very sensitive to the body temperature in the range from 35 to 42 °C, which is the scope range of clinical thermometer. The gel-to-sol transition temperatures enhanced with the increased concentrations of the gels. The reversible gel-sol transition, together with emission intensity and morphological changes, controlled by body temperature and ultrasound could be repeated by many circles without fatigue. Therefore, the gel could be developed to an ideal sensor for detecting human body temperature. 相似文献
67.
在 HL-2M 装置主机安装工艺方案制定和项目建设过程中采用 CAD&CAE 设计工艺分析方法,根据
各系统功能需求和安装进度需求,多次优化了主机安装工艺方案,对各系统之间的位置关系进行检查并对安装方
案进行了计算机辅助模拟,最终形成了完善的具有可实施性的安装工艺技术方案。对安装工艺方案进行了全面分
析与研究,总结论述了基准网的构建和关键部件的测量、绝缘与垫层工艺方案,装置核心区域磁导率控制等问题,
对未来聚变堆的建设与发展提供了有价值的设计和工艺参考。 相似文献
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69.
表面增强拉曼光谱技术在多环芳烃检测中的应用 总被引:2,自引:0,他引:2
多环芳烃(polycyclic aromatic hydrocarbons,PAHs)是一类致癌性很强的环境污染物.由于PAHs分子不含有能与金属配位或键合的官能团,因此很难利用SERS技术对其进行直接检测.本文综述了近年来表面增强拉曼散射(surface-enhanced Raman scattering,SERS)... 相似文献
70.