气相色谱灰色分析体系中未知组分保留指数的预测

提出在部分组分已知的气相色谱灰色体系中,利用已知组分的保留指数和保留时间推算死时间和正构烷烃的保留时间,再计算未知组分保留时间的方法,结果显示,在已知组分不是太少的情况下,该方法计算的死时间和正构烷烃的保留时间与实验值吻合,预测的保留指数也有较高的精度.     

The Mitochondria-Independent Cytotoxic Effect of Leflunomide on RPMI-8226 Multiple Myeloma Cell Line

Leflunomide, an anti-inflammatory agent, has been shown to be effective in multiple myeloma (MM) treatment; however, the mechanism of this phenomenon has not been fully elucidated. The aim of the study was to assess the role of mitochondria and dihydroorotate dehydrogenase (DHODH) inhibition in the cytotoxicity of leflunomide in relation to the MM cell line RPMI 8226. The cytotoxic effect of teriflunomide—an active metabolite of leflunomide—was determined using MTT assay, apoptosis detection, and cell cycle analysis. To evaluate DHODH-dependent toxicity, the cultures treated with teriflunomide were supplemented with uridine. Additionally, the level of cellular thiols as oxidative stress symptom was measured as well as mitochondrial membrane potential and protein tyrosine kinases (PTK) activity. The localization of the compound in cell compartments was examined using HPLC method. Teriflunomide cytotoxicity was not abolished in uridine presence. Observed apoptosis occurred in a mitochondria-independent manner, there was also no decrease in cellular thiols level. Teriflunomide arrested cell cycle in the G2/M phase which is not typical for DHODH deficiency. PTK activity was decreased only at the highest drug concentration. Interestingly, teriflunomide was not detected in the mitochondria. The aforementioned results indicate DHODH- and mitochondria-independent mechanism of leflunomide toxicity against RPMI 8226 cell line.     

抗震设防决策中的模糊信息处理

抗震设防决策过程中涉及到许多对整个分析过程都具有重要意义的模糊信息 ,本文提出一种结合模糊信息进行地震危险性概率分析与抗震设防决策的方法 ,介绍了用模糊集模拟模糊信息的原理 ,以及进一步处理模糊信息的区间分析顶点法。作为一例 ,这些方法结合基于泊松分布的地震烈度发生概率模型 ,应用于南京市区未来 5 0年的地震危险性与抗震设防效益分析 ,提供模糊的结论供设防决策参考。     

二维切口问题完备特征解的研究现状与进展

简要回顾和介绍了文献中常见的几种求解二维切口问题特征根的方法,评述这些方法 的特点及其求解范围．重点介绍了在求解二维切口问题完备特征根方面的一些进展,包括特征 根的求解方法、特征根的重根探讨以及相应的特征函数计算,这一问题基本上得到了解决．为 基于特征展开研究二维断裂问题打下了基础．      

Measuring the quality of discrete representations of efficient sets in multiple objective mathematical programming

One way of solving multiple objective mathematical programming problems is finding discrete representations of the efficient set. A modified goal of finding good discrete representations of the efficient set would contribute to the practicality of vector maximization algorithms. We define coverage, uniformity and cardinality as the three attributes of quality of discrete representations and introduce a framework that includes these attributes in which discrete representations can be evaluated, compared to each other, and judged satisfactory or unsatisfactory by a Decision Maker. We provide simple mathematical programming formulations that can be used to compute the coverage error of a given discrete representation. Our formulations are practically implementable when the problem under study is a multiobjective linear programming problem. We believe that the interactive algorithms along with the vector maximization methods can make use of our framework and its tools. Received April 7, 1998 / Revised version received March 1999?Published online November 9, 1999     

手性3-溴-2(5H)-呋喃酮的合成及其串联的不对称Michael加成 反应的研究

研究了新的手性试剂,5-(l-孟氧基)-3-溴-呋喃酮(5a)的合成及其与亲核性醇发生的串联不对称双Michael加成/分子内亲取代反应。通过此反应,一举生成了四个新的手性中心,得到了一般方法难以合成的含有多个手性中心的丁内酯并螺－环丙烷类化合物8a～8d。详细报道了8a～8d的合成方法以及它们的[α]、IR、UV、^1^HNMR、^13^CNMR、MS、元素分析等结构分析数据。此不对称双Michael加成/分子内亲核取代反应可以为某些新的光学活性螺－环内丙烷类化合物以及某些复杂结构的分子提供合成策略。     

吡啶和喹啉类化合物的碳-13核磁共振波谱模拟

运用多元回归分析和人工神经网法对１８个吡啶和喹啉类化合物的１１８个化学位移进行计算机模拟,并应用碳原子的空间和电子结构特征来表征其所处的化学环境,从而获得了比较好的相关模型。波谱模拟技术对辅助有机化合物结构解析和化学位移的确认是十分有用的工具。     

d维平稳高斯过程重点的不存在性和象集的一致Hausdorff维数

设X^d(t)(t∈R ）是d维可分的平稳高斯过程,在一定条件下,本文得到了X^d(t)象集的一致Hausdorff维数,证明了X^d(t)没有二重点,Polya过程为其特例。     

Modelling and control of two robotic manipulators handling a constrained object

In this paper, the problem of modelling and controlling two manipulators handling a constrained object is addressed. At first, a reduced order dynamic model of the system is derived, and several of its properties are outlined. Using the reduced order model, an adaptive control scheme that guarantees the asymptotic convergence of the position of the object, and the forces acting on the object to their desired values is developed. Simulation results of two planar robots moving an object along a plane illustrate the effectiveness of the proposed control scheme.     

非平稳MDP平均模型── 一致最优(G,B)-生成策略的存在性

本文考虑的是可数状态空间任意行动空间非平稳ＭＤＰ平均模型,借鉴于Ｆｅｉｎｂｅｒｇ Ｅ． Ａ（１９９４）的思想,提出了比马氏策略和 Ｆｅｉｎｂｅｒｇ Ｅ． Ａ的（ｆ,Ｂ）－生成策略和更为广泛的（Ｇ,Ｂ）－生成策略的概念,在弱遍历条件下,用概率分析的方法,证明了一致最优（Ｇ,Ｂ）－生成策略的存在性．从而将 Ｆｅｉｎｂｅｒｇ Ｅ． Ａ．（１９９４）的主要结果推广到非平衡可数状态空间情形．