Glucose Biosensor Based on Oxygen Electrode. Part II: Long-Term Operational Stability of the Rechargeable Glucose Biosensor

Abstract

A potentially implantable glucose biosensor for measuring blood or tissue glucose levels in diabetic patients has been developed. The glucose biosensor is based on an amperometric oxygen electrode and immobilized glucose oxidase enzyme, in which the immobilized enzyme can be replaced (the sensor recharged) without surgical removal of the sensor from the patient. Recharging of the sensor is achieved by injecting fresh immobilized enzyme into the sensor using a septum. A special technique for immobilization of the enzyme on Ultra-Low Temperature Isotropic (ULTI) carbon powder held in a liquid suspension has been developed.

In vitro studies of the sensors show stable performance during several recharge cycles over a period of 3 months of continuous operation.

Diffusion membranes which ensure linear dependence of the sensor response on glucose concentration have been developed. These membranes comprise silastic latex-rubber coatings over a microporous polycarbonate membrane. Calibration curves of the amperometric signal show linearity over a wide range of glucose concentrations (up to 16 mM), covering hypoglycemic, normoglycemic and hyperglycemic conditions.

The experimental results confirm the suitability of the sensors for in vitro measurements in undiluted human sera.     

Analyzing the Laws of Stable Subcritical Growth of Cracks in Polymeric Materials on the Basis of Fracture Mesomechanics Models. Theory and Experiment

The laws of stable crack growth are analyzed using fracture mesomechanics models for polymeric materials under long-term subcritical tension. A review is given of experimental and theoretical studies of crack-tip process zones. The studies were conducted using physical and mechanical methods and fracture mesomechanics models, allowing for the structural and rheological features of process zones. Theoretical and experimental results on the behavior of process zones are generalized and the theory of stable crack growth in viscoelastic polymers, which assumes the autonomy of the process zone during crack development, is justified     

高校实验教学立体化创新模式的探索与实践

本文在创新的"长效驱动机制"和"目标利益激励机制"下,就如何让教师创新积极性与学生创新积极性相结合,探索和实践将实验教学课与通识选修课相结合的立体化创新模式,以期达到让创新人才培养在教育中驻足,提高学生创新素质和创新能力。     

光电跟踪火控技术发展初步思考

从作战系统的组成出发,分析了光电跟踪设备在现代战争中的地位.针对三种不同光电跟踪设备的特点,根据网络中心战和火控系统的发展趋势,对其市场需求进行了分析.最后总结了国外光电跟踪火控技术的发展趋势,结合国内实际,对国内未来的发展提出了建议.     

1990年以来陕西省入境旅游市场特征及其趋势分析

本文主要分析1990年以来陕西省入境旅游市场总体增长态势,入境旅游市场的构成特点,旅游者消费结构的变化,以及陕西省入境旅游与全国及主要入境旅游城市的差距,并对陕西省入境旅游的趋势进行初步预测,提出开拓入境客源市场,扩大入境旅游市场的份额,推动陕西省旅游业的发展的一些建议和对策。     

全社会资金运行的多元统计分析

本文首先利用聚类分析、时差相关分析、K -L信息量等方法 ,以国内生产总值发展速度的波动曲线为基准循环曲线对各种经济指标进行分类和筛选 ,从而选定先行、一致 ,滞后三类指标组 ,然后运用主成分分析方法编制景气指数 ,得到先行、一致、滞后三类指标数 ,并结合我国改革开放以来的经济周期波动的实际 ,对所得到的景气指数进行分析 ,结果比较令人满意。     

Analitical Description of the Creep of Expanded Polystyrene under Compressive Loading

Data obtained in testing the creep of expanded polystyrene plates in compression are discussed. Power-type and exponential regression equations are used for describing the compression creep curves. Within the limits of data spread, both these equations represent experimental results equally well. A correlation between the creep strain and density, the compressive stress at a 10% strain, and the elastic modulus in compression is revealed for the material investigated.__________Translated from Mekhanika Kompozitnykh Materialov, Vol. 41, No. 4, pp. 525–534, July–August, 2005     

当代理论物理发展趋势之我见——杨振宁学术思想启发的若干思考

欣逢杨振宁先生百年诞辰,已有不少文章总结了杨先生对当代物理学发展的重要科学影响.笔者认为,作为当代最伟大的理论物理学家之一,杨先生不仅以诸多具体的科学贡献推动了当代物理学革命性的进步,而且其独特的科学风格在国际学术界独树一帜,其学术思想更是深邃隽永、对中国和世界的物理学发展有长远的启发作用.笔者将结合学习杨振宁科学思想的体会,联系自己在理论物理研究方面的科学实践(包括在1992—1994年跟随杨先生对量子开系统、超导相变和冷原子物理方面的探索),对当代理论物理发展趋势提出一些个人的看法.文章将通过具体实例,阐述为什么要做"美或有用"的理论物理;为什么基本物理的理论在一段时间内可以与直接的实验验证保持距离?对于后者,本文还从科学方法论(哲学)的角度就理论预言与实验证实的关系进行较为深入的讨论.着眼于"有用"的理论物理-应用理论物理,笔者强调了国家需求驱动的科学研究与自由探索一样,也会导致基础物理的重要突破.     

航空光电侦察技术发展研究北大核心CSCD

航空光电侦察具有隐蔽性强、直观性好、分辨率高等优点,一直是各国军事侦察的重要手段。根据作战任务需求,将航空光电系统分为凝视观瞄、情报侦察监视、红外搜索与跟踪、告警与对抗四大类。列举了典型产品,分析其特点及技术途径,从光学实现、稳定平台演进、瞄准线稳定、态势感知、轻量化、多任务协同、开放式系统架构(open systems architecture, OSA)等多方面分析国内外航空光电侦察技术和装备的发展情况及趋势。