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84.
Self-assembling properties of glycolipid biosurfactants and their potential applications 总被引:1,自引:0,他引:1
Dai Kitamoto Tomotake Morita Tokuma Fukuoka Masa-aki Konishi Tomohiro Imura 《Current Opinion in Colloid & Interface Science》2009,14(5):315-328
Biosurfactants (BS) produced by a variety of microorganisms show unique properties (e.g. mild production conditions, multi-functionality, higher environmental compatibility) compared to their chemical counterparts. The numerous advantages of BS have prompted applications not only in the food, cosmetic, and pharmaceutical industries but in environmental protection and energy-saving technology as well. Among BS, “Glycolipid type” BS are the most promising, due to high productivity from renewable resources and versatile interfacial and biochemical properties. Mannosylerythritol lipids (MELs), which are glycolipid BS produced by yeast strains of the genus Pseudozyma, not only exhibit excellent surface activities but also self-assemble to form different lyotropic liquid crystalline phases such as sponge (L3), bicontinuous cubic (V2) or lammellar (Lα). They also show induction of cell-differentiation against human leukemia cells, and high binding affinity towards lectins and immunoglobulins. Recently, the cationic liposome bearing MELs has been demonstrated to increase dramatically the efficiency of gene transfection into mammalian cells. These features of BS should broaden the applications in new advanced technologies. The current status of R&D on glycolipid BS, especially their functions and potential applications, is discussed. 相似文献
85.
After a long history and conflicting views, solid-contact (SC) solvent polymeric membrane ion-selective electrodes (ISEs)
emerged as reliable potentometric-sensing devices with unique advantages. From the large variety of proposed SCs inherently
conductive polymers emerged as the materials of choice. In our view, the most attractive feature of SC ISEs is their compatibility
with thin- and thick-film microfabrication technologies that can provide cheap, mass-produced sensors and sensor arrays that
can be integrated with the measuring, data acquisition, and control electronics in a straightforward way. However, despite
the impressive properties of certain SC electrodes and their potential advantages, they remained primarily in the research
laboratories. To make the jump from the research laboratories into commercial devices, it would be essential to prove that
miniaturized SC ISEs can indeed match or surpass the performance characteristics of the conventional, liquid-contact macroelectrodes.
In addition, it would be important to settle on the quality control criteria and testing protocols for assessing the performance
characteristics of SC electrodes. It could help in interpreting the sometimes-inconsistent experimental data. Once cheap,
miniaturized, SC ISEs will mach the performance characteristics of macroscopic-size electrodes, it is expected to have an
important impact in a variety of applications requiring robust, maintenance-free, or single-use ISEs, e.g., in homecare or
bedside diagnostics, environmental analysis, and quality control assessment. In addition, reliable SC ISEs are expected to
revitalize the field of ion-selective field effect transistors and open new possibilities in combination with nanowire-based
devices. 相似文献
86.
Elisaveta N. Samsonova Viktor M. Lutov Konstantin N. Mikhelson 《Journal of Solid State Electrochemistry》2009,13(1):69-75
Solid-contact electrode for pH measurements in acidic media is described. The sensor membrane is made of polyvinyl chloride
plasticized with bis(2-ethylhexyl)phthalate and contains neutral pH-selective ionophore hexabutyltriamidophosphate and potassium
tetrakis-p-Cl-phenylborate cation exchanger. The transducer layer of the solid-contact electrode contains the same membrane
composition and also carbon black and electron–ion-exchanger resin EI-21(a cation exchange resin containing fine dispersion
of metal copper) for stabilization of the electrode potential. The electrode is suitable for measurements of pH in the range
0–6 and works also in hydrofluoric acid (HF) solutions up to 0.1 M HF. Chronopotentiometric measurements show diffusion-limited
polarization at the interface between sensor membrane and transducer layer. The slope of the linearized polarization curve
correlates with the long-term stability of the electrode potentials providing a tool for prediction of the long-term stability
of solid-contact potentiometric sensors. 相似文献
87.
Solid-phase microextraction gas chromatography-mass spectrometry determination of fragrance allergens in baby bathwater 总被引:1,自引:0,他引:1
J. Pablo Lamas Lucia Sanchez-Prado Carmen Garcia-Jares Maria Llompart 《Analytical and bioanalytical chemistry》2009,394(5):1399-1411
A method based on solid-phase microextraction (SPME) and gas chromatography-mass spectrometry (GC-MS) has been optimized for
the determination of fragrance allergens in water samples. This is the first study devoted to this family of cosmetic ingredients
performed by SPME. The influence of parameters such as fibre coating, extraction and desorption temperatures, salting-out
effect and sampling mode on the extraction efficiency has been studied by means of a mixed-level factorial design, which allowed
the study of the main effects as well as two-factor interactions. Excluding desorption temperature, the other parameters were,
in general, very important for the achievement of high response. The final procedure was based on headspace sampling at 100 °C,
using polydimethylsiloxane/divinylbenzene fibres. The method showed good linearity and precision for all compounds, with detection
limits ranging from 0.001 to 0.3 ng mL−1. Reliability was demonstrated through the evaluation of the recoveries in different real water samples, including baby bathwater
and swimming pool water. The absence of matrix effects allowed the use of external standard calibration to quantify the target
compounds in the samples. The proposed procedure was applied to the determination of allergens in several real samples. All
the target compounds were found in the samples, and, in some cases, at quite high concentrations. The presence and the levels
of these chemicals in baby bathwater should be a matter of concern.
Baby exposure to fragrance allergens and other cosmetic ingredients through the daily bath 相似文献
88.
In this review, recent methods developed for the determination of degradation intermediates of personal care products in environmental
matrixes focusing on the extraction and determination steps are discussed. The five classes of personal care products evaluated
are stimulants, fragrances, sunscreens, antimicrobials, and insect repellents. Methods are critically reviewed in terms of
the analytical steps involved in the analysis, sample pretreatment, separation, and detection as well as the different confirmation
strategies employed. Preconcentration from aqueous matrixes was performed by solid-phase extraction, liquid–liquid extraction,
or solid-phase microextraction, allowing the simultaneous extraction of parent compounds and their degradation intermediates.
Following the extraction and cleanup steps, the identification and quantification of degradation intermediates of personal
care products at environmental levels (i.e., parts per trillion to parts per billion range) is usually performed by using
mass spectrometry techniques such as single quadrupole mass spectrometry and more recently by time-of-flight mass spectrometry
or tandem mass spectrometry. The main scope of this review is to critically evaluate the current state of the art of the analytical
techniques used and to identify the research needs in the determination of degradation intermediates of personal care products
in environmental matrixes. 相似文献
89.
Szigeti Z Malon A Vigassy T Csokai V Grün A Wygladacz K Ye N Xu C Chebny VJ Bitter I Rathore R Bakker E Pretsch E 《Analytica chimica acta》2006,572(1):1-10
Ten Ag+-selective ionophores have been characterized in terms of their potentiometric selectivities and complex formation constants in solvent polymeric membranes. The compounds with π-coordination show much weaker interactions than those with thioether or thiocarbamate groups as the coordinating sites. Long-term studies with the best ionophores show that the lower detection limit of the best Ag+ sensors can be maintained in the subnanomolar range for at least 1 month. The best ionophores have also been characterized in fluorescent microspheres. The so far best lower detection limits of 3 × 10−11 M (potentiometrically) and 2 × 10−11 M Ag+ (optically) are found with bridged thiacalixarenes. 相似文献
90.
Griffiths J. D.; Price-Lloyd N.; Smithies M.; Williams J. 《IMA Journal of Management Mathematics》2006,17(3):277-288
** Email: griffiths{at}cardiff.ac.uk Activities in an intensive care unit (ICU) at a major teachinghospital are modelled by means of a queue-theoretic approach.Using data supplied by the ICU relating to the admissions process,the bed availability and the length of stay of patients, itwas possible to fit theoretical distributions to the observedarrival and service distributions.Queueing equations relevant to a multi-channel system havingrandom arrivals and hyper-exponential service times for eachchannel are set up, and solved iteratively. Results obtainedmatch well with observations, and the model is then utilisedto investigate several what if? scenarios. Referenceis made to a simulation model developed in conjunction withthe queueing model. 相似文献