Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy

Fast identification of binding activity directly from mixtures of potential ligands is possible with the NMR method described, which is based on saturation transfer to molecules in direct contact to a protein. In addition, the ligand's binding epitope is easily identified. High sensitivity and ease of use are the principal advantages of this method. The picture shows the normal 1D NMR spectrum of a mixture and the spectrum obtained by applying the STD method, which exclusively shows signals from molecules with binding affinity.     

Combinatorial Materials Science and Catalysis

After forever changing the drug discovery process in the pharmaceutical industry, combinatorial chemistry methodologies are increasingly being applied to the discovery and optimization of more efficient catalysts and materials (see picture). With the advent of new combinatorial synthesis and screening technologies, coupled with integrated data management systems, the application of these technologies to materials science and catalyst research holds tremendous potential and brings high expectations to this new and exciting field.     

Detection of Reaction Selectivity on Catalyst Libraries by Spatially Resolved Mass Spectrometry

In 2-mm microreactors the activity and selectivity of catalyst library components can be monitored directly by robot-controlled mass spectrometry (the principle setup is shown in the scheme). A maximum of 60 seconds per library component are required.     

A New Heterocyclic Multicomponent Reaction For the Combinatorial Synthesis of Fused 3-Aminoimidazoles

When general and reliable , multicomponent reactions are among the most powerful tools in modern drug discovery. The principle of chemical ligation of reactive partners (see reaction scheme) has been employed to find a new, highly efficient synthesis of fused 3-aminoimidazoles.     

Combinatorial Material Libraries on the Microgram Scale with an Example of Hydrothermal Synthesis

In a 8-μL multichambered microreactor (the photo shows the components) material libraries can be produced in a simple manner through combinatorial hydrothermal synthesis. In a model experiment the synthesis of the zeolite TS-1 has been varied combinatorially. The resulting library is characterized directly by automated microdiffraction.     

组合化学——合成化学领域的一次革命

组合化学是近十几年逐渐发展成熟起来的一个学科,它从根本上改变了化学家、生物学家以及相关学科研究人员的思维和研究方式,对科学的发展产生了革命性的影响。组合化学从创立起就与工业应用紧密联系在一起,它带动了包括新药发明和新材料研制在内的一系列高新科技产业的发展。下面简述了组合化学的起源与发展、研究方法及其对相关学科的影响和技术前景。