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11.
血清钙、镁和微量元素与冠心病 总被引:3,自引:1,他引:3
综述了钙、镁和微量元素在动脉粥样硬化、冠心病(包括冠状动脉痉挛)研究的相关报道,以进一步研究钙、镁和微量元素与冠状动脉痉挛的关系。 相似文献
12.
Syntheses of Two Potential Ligands for Tc-99m Labeling as Diagnosis Agents of Alzheimer''''s Disease
Two types of ligands-biphenyl and stilbene derivatives, whichcan be labeled with Tc-99m for the diagnosis of Alzheimer'sdisease (AD) have been synthesized successfully. The key stepsin these two syntheses involved Suzuki reaction and Wittig reac-tion respectively. The new discovered debromination reactionmay be expanded to the compounds with double or triple bondadjacent to the carbon atom bearing the bromine atoms. Thesetypes of syntheses provide a route to a series of biphenyl andstilbene derivatives that will benefit the search of new imagingagents for AD. 相似文献
13.
心脑血管病患者头发微量元素铜、锌含量调查 总被引:1,自引:0,他引:1
调查了心脑血管病患者头发微量元素铜、锌含量,发现患者发现Cu、Zn含量普通遇低于正常值。 相似文献
14.
Summary In the preceding paper we reported on a docking study with the SYSDOC program for predicting the binding sites of huperzine A in acetylcholinesterase (AChE) [Pang, Y.-P. and Kozikowski, A.P., J. Comput.-Aided Mol. Design, 8 (1994) 669]. Here we present a prediction of the binding sites of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine (E2020) in AChE by the same method. E2020 is one of the most potent and selective reversible inhibitors of AChE, and this molecule has puzzled researchers, partly due to its flexible structure, in understanding how it binds to AChE. Based on the results of docking 1320 different conformers of E2020 into 69 different conformers of AChE and on the pharmacological data reported for E2020 and its analogs, we predict that both the R- and the S-isomer of E2020 span the whole binding cavity of AChE, with the ammonium group interacting mainly with Trp84, Phe330 and Asp72, the phenyl group interacting mainly with Trp84 and Phe330, and the indanone moiety interacting mainly with Tyr70 and Trp279. The topography of the calculated E2020 binding sites provides insights into understanding the high potency of E2020 in the inhibition of AChE and provides hints as to possible structural modifications for identifying improved AChE inhibitors as potential therapeutics for the palliative treatment of Alzheimer's disease. 相似文献
15.
Benoit Bachand Mohamed Atfani Bita Samim Sophie Lévesque Daniel Simard Xianqi Kong 《Tetrahedron letters》2007,48(49):8587-8589
A practical synthetic route to various 2-alkylpropane-1,3-sultones, the key intermediates for the preparation of 2-substituted homotaurines as analogs of tramiprosate, was developed. 相似文献
16.
Boris Pejin Kristina Tešanović Dragica Jakovljević Sonja Kaišarević Filip Šibul Milena Rašeta 《Natural product research》2019,33(5):750-754
The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease. 相似文献
17.
116例冠心病患者血清中钙镁钡铝锶含量的研究 总被引:1,自引:0,他引:1
测定116例冠心病患者血清中钙,镁,钡,铝和锶的含量并与正常值比较,常量元素钙,镁和微量元素锶降低,而微量元素钡和铝升高,它们之间的差异都有显著或高度显著性。P〈0.05或P〈0.01。 相似文献
18.
化工工人体内微量元素积累与健康的关系 总被引:1,自引:0,他引:1
胡文玉 《广东微量元素科学》1998,5(7):6-8
论述了化工作业工人长期接触有害元素会引起体内有害元素积蓄,微量元素平衡失调,产生潜在的职业危害,建议定期对临床尚未发现中毒现象的作业工人进行体内微量元素情况监控,以预防职业中毒。并提出采用适当补充某些必需元素的方法,可预防这种危害。 相似文献
19.
内蒙古牧区老年冠心病患者血清Zn,Cu,Ca,Mg的测定及临床意义 总被引:1,自引:0,他引:1
用薄样X射线荧光光谱法测定较区91老年冠心病患者及63名老年健康人血清Zn、Cu、Ca、Mg、四种元素的含量。结果表明:牧区老年冠心病患者血清中Zn、Cu、含量与健康组比较无显著差异,但两者的比值高于对照组,可能与牧区牧民饮食习惯有关;老年冠心病组血清Ca、Mg含量显著低于对照组。 相似文献
20.
《印度化学会志》2021,98(10):100156
Corona virus disease 2019 (COVID-19) endemic has havoc on the world; the causative virus of the pandemic is SARS CoV-2. Pharmaceutical companies and academic institutes are in continuous efforts to identify anti-viral therapy or vaccines, but the most significant challenge faced is the highly evolving genome of SARS CoV-2, which is imparting evolutionary selective benefits to the virus. To understand the viral mutations, we have retrieved nine hundred and thirty-four samples from different states of India via the GISAID database and analyzed the frequency of all types of point mutation in all structural, non-structural proteins, and accessory factors of SARS CoV-2. Spike glycol protein, nsp3, nsp6, nsp12, N and NS3 were the most evolving proteins. High frequency point mutations were Q496P (nsp2), A380V (nsp4), A994D (nsp3), L37F (nsp6), P323L & A97V (nsp12), Q57H (ns3), D614G (S), P13L (N), R203K (N), G204R (N) and S194L (N). 相似文献